Interleukin-6 and interleukin-1B polymorphisms show different interaction patterns with stressors on trait anxiety

Abstract

Neuroinᴀammatory mechanisms received more and more attention recently in neuroscience examining depression and anxiety. Disturbances in the genetic expression pro le of proinᴀammatory cytokines such as Interleukin-1B (IL-1B) and Interleukin-6 (IL-6) has been reported to inᴀuence these mood disorder pheontypes profoundly, however it has been also shown that different stressors are needed to exert such effect. That means that signi cant main effects of these genes on depression and anxiety are lacking, but highly signi cant interaction effects could be observed even after correcting for multiple testing [1,2]