Interleukin 6 and complement serum level study in Parkinson’s disease

Veselý, Branislav; Dufek, Michal; Thon, Vojtěch; Brozman, M; Királová, Silvia; Halászová, Tatiana; Koriťáková, Eva; Rektor, Ivan

doi:10.1007/s00702-018-1857-5

Cited by 39 publications

(24 citation statements)

References 38 publications

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“…However, females are more likely to suffer from cognitive disorders, pain symptoms, and depression (Georgiev et al, 2017). PD patients who had higher levels of serum C3 and C4 at baseline and maintained consistently high levels over 2 years had a worse quality of life and memory ability (Veselı et al, 2018). After adjusting for other clinical factors, we found that the serum C3 level was inversely correlated with male gender, age, and the severity of sleep/fatigue problems.…”

Section: Discussionmentioning

confidence: 99%

Peripheral Humoral Immune Response Is Associated With the Non-motor Symptoms of Parkinson’s Disease

Sun

Zhao

et al. 2019

Front. Neurosci.

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BackgroundNon-motor symptoms are common in Parkinson’s disease (PD) and can even be used as part of the supportive criteria for diagnosis. Chronic inflammation is involved in every stage of PD. Disorders of the immune system affect the peripheral blood. Whether the humoral immune response is associated with the non-motor symptoms of PD remains unknown.MethodsMann–Whitney tests and Bonferroni correction were used to compare the serum levels of IgG, IgA, IgM, C3, and C4 between 180 sporadic PD patients and 187 healthy controls. Multiple regression models were conducted to assess the associations among these indicators of humoral immunity and the clinical features of PD patients.ResultsMale PD patients had lower levels of C3 and C4 than healthy controls [0.87 (0.22) vs. 0.96 (0.19); 0.19 (0.06) vs. 0.22 (0.07), respectively, Pc < 0.01] and lower levels of C3 than female PD patients [0.87 (0.22) vs. 1.02 (0.23), Pc < 0.01]. Patients suffering from attention/memory problems had significantly lower levels of IgA and C3 than those without these problems [1.92 (1.21) vs. 2.57 (0.76); 0.89 (0.24) vs. 0.97 (0.24), respectively, Pc < 0.04]. In addition, serum IgG levels were negatively associated with mood/cognition problem scores and were positively associated with gastrointestinal tract problem scores (adjusted R2 = 0.063, F = 1.805, p = 0.038). Serum C3 levels were negatively associated with being male, age, and sleep/fatigue problem scores (adjusted R2 = 0.123, F = 2.678, p = 0.001).ConclusionThe peripheral humoral immune response might be correlated with the non-motor symptoms of PD.

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Section: Discussionmentioning

confidence: 99%

Peripheral Humoral Immune Response Is Associated With the Non-motor Symptoms of Parkinson’s Disease

Sun

Zhao

et al. 2019

Front. Neurosci.

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“…Increased inflammatory responses have been described both in the brain and peripheral blood of PD patients (135). Depression correlated with a high serum level of IL-10 (136) and IL-6 (137). High levels of both sIL-2R and TNF-α in blood samples from PD patients were significantly associated with more severe depression and anxiety (119).…”

Section: Depressionmentioning

confidence: 99%

Biomarkers for Dementia, Fatigue, and Depression in Parkinson's Disease

2019

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Parkinson's disease is a common multisystem neurodegenerative disorder characterized by typical motor and non-motor symptoms. There is an urgent need for biomarkers for assessment of disease severity, complications and prognosis. In addition, biomarkers reporting the underlying pathophysiology assist in understanding the disease and developing neuroprotective therapies. Ultimately, biomarkers could be used to develop a more efficient personalized approach for clinical trials and treatment strategies. With the goal to improve quality of life in Parkinson's disease it is essential to understand and objectively monitor non-motor symptoms. This narrative review provides an overview of recent developments of biomarkers (biofluid samples and imaging) for three common neuropsychological syndromes in Parkinson's disease: dementia, fatigue, and depression.

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“…These results suggest that non-steroidal anti-inflammatory drugs could perhaps be used to treat major depressive disorders. Interestingly, the increase in IL-6 in childhood enhances the risk of developing depression later in life [243], and there is a relationship between high IL-6 levels and depression in patients with PD [244]. Figure 6 reports the main mechanisms involved in depression.…”

Section: Depressionmentioning

confidence: 99%

Innate Immunity: A Common Denominator between Neurodegenerative and Neuropsychiatric Diseases

Novellino

Saccà

Donato

et al. 2020

IJMS

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The intricate relationships between innate immunity and brain diseases raise increased interest across the wide spectrum of neurodegenerative and neuropsychiatric disorders. Barriers, such as the blood–brain barrier, and innate immunity cells such as microglia, astrocytes, macrophages, and mast cells are involved in triggering disease events in these groups, through the action of many different cytokines. Chronic inflammation can lead to dysfunctions in large-scale brain networks. Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal dementia, are associated with a substrate of dysregulated immune responses that impair the central nervous system balance. Recent evidence suggests that similar phenomena are involved in psychiatric diseases, such as depression, schizophrenia, autism spectrum disorders, and post-traumatic stress disorder. The present review summarizes and discusses the main evidence linking the innate immunological response in neurodegenerative and psychiatric diseases, thus providing insights into how the responses of innate immunity represent a common denominator between diseases belonging to the neurological and psychiatric sphere. Improved knowledge of such immunological aspects could provide the framework for the future development of new diagnostic and therapeutic approaches.

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Interleukin 6 and complement serum level study in Parkinson’s disease

Cited by 39 publications

References 38 publications

Peripheral Humoral Immune Response Is Associated With the Non-motor Symptoms of Parkinson’s Disease

Peripheral Humoral Immune Response Is Associated With the Non-motor Symptoms of Parkinson’s Disease

Biomarkers for Dementia, Fatigue, and Depression in Parkinson's Disease

Innate Immunity: A Common Denominator between Neurodegenerative and Neuropsychiatric Diseases

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