2018
DOI: 10.1684/ecn.2018.0406
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Interleukin-6 and cardiac operations

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Cited by 13 publications
(12 citation statements)
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“…Although the pathogenesis of POAF remains uncertain, accumulating evidence suggest an important role of inflammatory mechanisms and mediators. In particular, the interleukin-6 (IL-6), recognized as a primary cytokine in the inflammatory cascade, has been identified as one of the main molecules involved in the development of POAF (4,(7)(8)(9). Interestingly, the epicardial adipose tissue (EAT), the visceral fat depot of the heart, produces numerous pro-inflammatory cytokines which can affect the myocardium through paracrine or vasocrine mechanisms (10,11).…”
Section: Introductionmentioning
confidence: 99%
“…Although the pathogenesis of POAF remains uncertain, accumulating evidence suggest an important role of inflammatory mechanisms and mediators. In particular, the interleukin-6 (IL-6), recognized as a primary cytokine in the inflammatory cascade, has been identified as one of the main molecules involved in the development of POAF (4,(7)(8)(9). Interestingly, the epicardial adipose tissue (EAT), the visceral fat depot of the heart, produces numerous pro-inflammatory cytokines which can affect the myocardium through paracrine or vasocrine mechanisms (10,11).…”
Section: Introductionmentioning
confidence: 99%
“…Although the pathogenesis of POAF remains uncertain, accumulating evidence suggest an important role of in ammatory mechanisms and mediators. In particular, the interleukin-6 (IL-6), recognized as a primary cytokine in the in ammatory cascade, has been identi ed as one of the main molecules involved in the development of POAF (4,(7)(8)(9). Interestingly, the epicardial adipose tissue (EAT), the visceral fat depot of the heart, produces numerous pro-in ammatory cytokines which can affect the myocardium through paracrine or vasocrine mechanisms (10,11).…”
Section: Introductionmentioning
confidence: 99%
“…Interleukin-6 (IL-6) is a pleiotropic cytokine with both pro-and anti-in ammatory capacities, produced by different cells and tissues, such as leukocytes, adipocytes, and endothelium [1,2]. Accordingly, elevated concentrations of IL-6 may indicate an ongoing in ammatory response due to systemic or localized infection or chronic in ammatory disease [1][2][3][4]. IL-6 plasma levels correlate with NF-κB-dependent endothelial dysfunction, arterial stiffness, and the extent of subclinical atherosclerosis [1,2].…”
Section: Introductionmentioning
confidence: 99%
“…Accordingly, elevated concentrations of IL-6 may indicate an ongoing in ammatory response due to systemic or localized infection or chronic in ammatory disease [1][2][3][4]. IL-6 plasma levels correlate with NF-κB-dependent endothelial dysfunction, arterial stiffness, and the extent of subclinical atherosclerosis [1,2]. IL-6 has also been implicated in metabolic regulation and especially in lipid metabolic homeostasis, being predictive of incident type 2 diabetes and obesity [3,4].…”
Section: Introductionmentioning
confidence: 99%