Interleukin-6 and cardiac operations

Yuan, Shi‐Min

doi:10.1684/ecn.2018.0406

Cited by 13 publications

(12 citation statements)

References 106 publications

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“…Although the pathogenesis of POAF remains uncertain, accumulating evidence suggest an important role of inflammatory mechanisms and mediators. In particular, the interleukin-6 (IL-6), recognized as a primary cytokine in the inflammatory cascade, has been identified as one of the main molecules involved in the development of POAF (4,(7)(8)(9). Interestingly, the epicardial adipose tissue (EAT), the visceral fat depot of the heart, produces numerous pro-inflammatory cytokines which can affect the myocardium through paracrine or vasocrine mechanisms (10,11).…”

Section: Introductionmentioning

confidence: 99%

Epicardial Adipose Tissue and Postoperative Atrial Fibrillation

Petraglia

Conte

Castaldo

et al. 2022

Front. Cardiovasc. Med.

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BackgroundAtrial fibrillation (AF) often occurs after cardiac surgery and is associated with increased risk of stroke and mortality. Prior studies support the important role of inflammation in the pathogenesis of postoperative atrial fibrillation (POAF). It is known that an increased volume and a pro-inflammatory phenotype of epicardial adipose tissue (EAT) are both associated with AF onset in non surgical context. In the present study, we aim to evaluate whether also POAF occurrence may be triggered by an increased production of inflammatory mediators from EAT.MethodsThe study population was composed of 105 patients, with no history of paroxysmal or permanent AF, undergoing elective cardiac surgery. After clinical evaluation, all patients performed an echocardiographic study including the measurement of EAT thickness. Serum samples and EAT biopsies were collected before surgery. Levels of 10 inflammatory cytokines were measured in serum and EAT conditioned media. After surgery, cardiac rhythm was monitored for 7 days.ResultsForty-four patients (41.3%) developed POAF. As regard to cardiovascular therapy, only statin use was significantly lower in POAF patients (65.1% vs. 84.7%; p-0.032). Levels of Monocyte Chemoattractant Protein-1 (MCP-1), in both serum and EAT, were significantly higher in POAF patients (130.1 pg/ml vs. 68.7 pg/ml; p = <0.001; 322.4 pg/ml vs. 153.4 pg/ml; p = 0.028 respectively). EAT levels of IL-6 were significantly increased in POAF patients compared to those in sinus rhythm (SR) (126.3 pg/ml vs. 23 pg/ml; p = <0.005).ConclusionHigher EAT levels of IL-6 and MCP-1 are significantly associated with the occurrence of POAF. Statin therapy seems to play a role in preventing POAF. These results might pave the way for a targeted use of these drugs in the perioperative period.

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Section: Introductionmentioning

confidence: 99%

Epicardial Adipose Tissue and Postoperative Atrial Fibrillation

Petraglia

Conte

Castaldo

et al. 2022

Front. Cardiovasc. Med.

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“…Although the pathogenesis of POAF remains uncertain, accumulating evidence suggest an important role of in ammatory mechanisms and mediators. In particular, the interleukin-6 (IL-6), recognized as a primary cytokine in the in ammatory cascade, has been identi ed as one of the main molecules involved in the development of POAF (4,(7)(8)(9). Interestingly, the epicardial adipose tissue (EAT), the visceral fat depot of the heart, produces numerous pro-in ammatory cytokines which can affect the myocardium through paracrine or vasocrine mechanisms (10,11).…”

Section: Introductionmentioning

confidence: 99%

Epicardial Adipose Tissue and Postoperative Atrial Fibrillation

Petraglia¹,

Conte²,

Castaldo³

et al. 2021

Preprint

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Background. Atrial fibrillation (AF) often occurs after cardiac surgery and is associated to increased risk of stroke and mortality. Several evidence support the important role of inflammation in the pathogenesis of postoperative atrial fibrillation (POAF). It is known that an increased volume and a pro-inflammatory phenotype of epicardial adipose tissue (EAT) are both associated with AF onset in non surgical context. In the present study, we aim to evaluate whether also POAF occurrence may be triggered by an exalted production of inflammatory mediators from EAT.Methods. The study population was composed of 105 patients, with no history of paroxysmal or permanent AF, undergoing elective cardiac surgery. After clinical evaluation, all patients performed an echocardiographic study including the measurement of EAT thickness. Serum samples and EAT biopsies were collected before surgery. Levels of 10 inflammatory cytokines were measured in serum and EAT conditioned media. After surgery, cardiac rhythm was monitored for 7 days.Results. Forty-four patients (41.3%) developed POAF. As regard to cardiovascular therapy, only statin use was significantly lower in POAF patients (65.1% vs. 84.7%; p-0.032). Levels of Monocyte Chemoattractant Protein-1 (MCP-1), in both serum and EAT, were significantly higher in POAF patients (130.1 pg/ml vs. 68.7 pg/ml; p = < 0.001; 322.4 pg/ml vs. 153.4 pg/ml; p = 0.028 respectively). EAT levels of IL-6 were significantly increased in POAF patients compared to those in sinus rhythm (126.3 pg/ml vs. 23 pg/ml; p = < 0.005).ConclusionHigher EAT levels of IL6 and MCP1 are significantly associated with the occurrence of POAF. Statin therapy seems to play a role in preventing POAF. These results might pave the way for a targeted use of these drugs in the perioperative period.

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“…Interleukin-6 (IL-6) is a pleiotropic cytokine with both pro-and anti-in ammatory capacities, produced by different cells and tissues, such as leukocytes, adipocytes, and endothelium [1,2]. Accordingly, elevated concentrations of IL-6 may indicate an ongoing in ammatory response due to systemic or localized infection or chronic in ammatory disease [1][2][3][4]. IL-6 plasma levels correlate with NF-κB-dependent endothelial dysfunction, arterial stiffness, and the extent of subclinical atherosclerosis [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…Accordingly, elevated concentrations of IL-6 may indicate an ongoing in ammatory response due to systemic or localized infection or chronic in ammatory disease [1][2][3][4]. IL-6 plasma levels correlate with NF-κB-dependent endothelial dysfunction, arterial stiffness, and the extent of subclinical atherosclerosis [1,2]. IL-6 has also been implicated in metabolic regulation and especially in lipid metabolic homeostasis, being predictive of incident type 2 diabetes and obesity [3,4].…”

Section: Introductionmentioning

confidence: 99%

Interleukin-6 and vitamin D serum levels in patients with obstructive sleep apnea syndrome before and after long-term continuous positive airway pressure treatment

Kotsiou

Siachpazidou

Pastaka

et al. 2020

Preprint

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Background: Hypoxia induces the production of adipocyte-derived mediators such as IL-6 in obstructive sleep apnea syndrome (OSAS). Low serum 25-hydroxyvitamin D (25(OH)D) levels have been linked to OSAS susceptibility. No data exist to assess whether there has been a correlation between vitamin D and IL-6 serum levels. The effect of CPAP therapy on IL-6 or 25(OH)D levels has yet to be investigated sufficiently in OSAS. We aimed at determining the serum levels of 25(OH)D and IL-6 in OSAS patients compared to non-apneic controls, investigating a possible correlation between 25(OH)D and IL-6 levels and evaluating the changes in IL-6 and 25(OH)D concentrations after twelve months of CPAP therapy in OSAS patients.Methods: 15 OSAS patients diagnosed by polysomnography and 15 non-apneic controls were included in the study. Serum IL-6 and 25(OH)D levels were measured before and after twelve-month CPAP therapy in the whole population and OSAS group, respectively.Results: IL-6 levels were significantly elevated in the OSAS group than the controls. IL-6 levels were positively correlated with OSAS severity, nocturnal hypoxemia, and body mass index (BMI). No difference was detected in 25(OH)D serum levels between groups. We found no correlation between IL-6 and 25(OH)D serum levels in two groups. No effect on IL-6 or 25(OH)D levels was detect after one year of effective CPAP therapy in OSAS patients.Conclusions: IL-6 levels were correlated with OSAS severity, hypoxemia, and BMI. No correlation between 25(OH)D and IL-6 levels and no effect of long-term CPAP on biomarkers were found in OSAS patients.

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Interleukin-6 and cardiac operations

Cited by 13 publications

References 106 publications

Epicardial Adipose Tissue and Postoperative Atrial Fibrillation

Epicardial Adipose Tissue and Postoperative Atrial Fibrillation

Epicardial Adipose Tissue and Postoperative Atrial Fibrillation

Interleukin-6 and vitamin D serum levels in patients with obstructive sleep apnea syndrome before and after long-term continuous positive airway pressure treatment

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