Interleukin-41 diminishes cigarette smoke-induced lung inflammation in mice

Cen, Tiantian; Mai, Yifeng; Jin, Jie; Huang, Minxuan; Li, Mingcai; Wang, Shanshan; Ma, Hongying

doi:10.1016/j.intimp.2023.110794

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…Use of a combination of factors significantly improved the efficiency of AECOPD diagnosis. A previous study by the authors also revealed that IL-41, which suppresses cigarette smoke-induced pulmonary inflammation in vivo in mice, can be used therapeutically to treat inflammatory lung conditions ( 29 ). According to earlier investigations, IL-41 level has been linked to diabetes and coronary heart disease, and the plasma IL-41 level in patients with AECOPD with diabetes mellitus and coronary heart disease was found to be lower than that in patients with AECOPD without diabetes and coronary heart disease ( 9 ).…”

Section: Discussionmentioning

confidence: 96%

Increased serum IL‑41 associated with acute exacerbation of chronic obstructive pulmonary disease

Cen,

Huang,

et al. 2024

Exp Ther Med

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Interleukin (IL)-41 is a novel immunomodulatory cytokine involved in the pathogenesis of several inflammatory and metabolic illnesses. However, it remains unclear how IL-41 contributes to the pathogenesis of chronic obstructive pulmonary disease (COPD). Therefore, the aim of the present study was to explore the correlation between the expression level of IL-41 and acute exacerbation of COPD (AECOPD). In total, 107 patients with COPD and 56 healthy controls were recruited from the First Affiliated Hospital of Ningbo University (Ningbo, China). Serum IL-41, IL-6, and matrix metalloproteinase-2 (MMP-2) levels were evaluated using enzyme-linked immunosorbent assay. Serum amyloid A (SAA) and C-reactive protein (CRP) levels were assessed in the hospital laboratory. The levels of IL-41 were higher in the AECOPD group than in the stable COPD (SCOPD) and control groups (P<0.0001). IL-6, SAA and CRP levels, the percentage of neutrophils, as well as neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios were higher in the AECOPD group than those in the SCOPD and control groups. The smoking index was positively correlated with serum IL-41, CRP and SAA levels. The expression level of IL-41 was correlated with the number of acute exacerbations, severity of the exacerbations, and COPD assessment test scores in the AECOPD group. Examination of the receiver operating characteristic (ROC) curves showed that IL-41, especially when combined with other inflammatory factors, had a specific diagnostic value for AECOPD. According to the ROC curve analysis, the area under the curve (AUC) for IL-41 was 0.742 (P=0.051), and the AUC for IL-41 combined with other inflammatory factors was 0.925 (P=0.030). Increased serum IL-41 levels were associated with AECOPD and may play a role in the monitoring and evaluation of COPD.

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Section: Discussionmentioning

confidence: 96%

Increased serum IL‑41 associated with acute exacerbation of chronic obstructive pulmonary disease

Cen,

Huang,

et al. 2024

Exp Ther Med

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“…In addition, IL-41 plays a key anti-inflammatory role in several inflammatory diseases such as psoriatic arthritis and inflammatory bowel disease ( 24 – 26 ). IL-41 can regulate cytokine levels through macrophages and is involved in the modulation of inflammatory responses in a mouse model of sepsis ( 27 , 28 ). However, the role and mechanism of IL-41 in cancer are currently unclear.…”

Section: Introductionmentioning

confidence: 99%

Interleukin-41: a novel serum marker for the diagnosis of alpha-fetoprotein-negative hepatocellular carcinoma

Li,

Wang,

Ren

et al. 2024

Front. Oncol.

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BackgroundFor the lack of effective serum markers for hepatocellular carcinoma(HCC) diagnosis, it is difficult to detect liver cancer and identify its recurrence early.MethodsDatabases were used to analyze the genes potentially associated with alpha-fetoprotein(AFP). ELISA assay was used to detect the serum IL-41 in HCC, liver metastases, hepatitis, and healthy people. Immunohistochemical staining was used to analyze the relative quantification of IL-41 in HCC and paracancer tissues. Various survival curves were plotted according to clinical pathological data and helped us draw the ROC curve of IL-41 diagnosis of HCC.ResultsThe serum expression of IL-41 was highest in AFP negative HCC patients and significantly higher than that in AFP positive HCC and metastatic cancer patients. There was a significant negative correlation between elevated serum IL-41 and AFP(<1500ng/ml). The clinicopathological features suggested that the serum IL-41 level was significantly correlated with capsule invasion, low differentiation and AFP. High serum expression of IL-41 suggests poorer survival and earlier recurrence after resection, and IL-41 upregulated in patients with early recurrence and death. The expression of IL-41 was higher in HCC tissues of patients with multiple tumors or microvascular invasion. The ROC curve showed that serum IL-41 had a sensitivity of 90.17 for HCC and a sensitivity of 96.63 for AFP-negative HCC, while the specificity was higher than 61%.ConclusionIL-41 in serum and tissue suggests poor prognosis and postoperative recurrence in HCC patients and could be a new serum diagnostic marker for AFP negative patients.

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Homotherapy for heteropathy: Interleukin‐41 and its biological functions

Shi,

He,

Peng

et al. 2024

Immunology

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Interleukin‐41 (IL‐41) is a newly discovered cytokine, named Cometin, Subfatin, meteorin‐like transcription (Metrnl), and so forth. It is widely expressed in animals and can exert its biological roles through autocrine and paracrine forms. It has functions such as anti‐inflammatory, improving body metabolism, regulating immunity, regulating fat metabolism and participates in the process of autoimmune disease or inflammatory injury. It plays an important role in psoriasis, diabetes, Crohn's disease (CD), osteoarthritis, Kawasaki disease (KD), Graves' disease, autoimmune hepatitis, infertility, obesity, sepsis, cardiovascular diseases and respiratory diseases. This paper reviews the biological functions of IL‐41, the relationship between IL‐41 and diseases, the effects of IL‐41 in the cytokine network and the possible signalling pathways. In order to explore the same target or the same drug for the treatment of different diseases from the perspective of homotherapy for heteropathy, cytokine strategies based on IL‐41 have been put forward for the precise treatment of immune diseases and inflammatory diseases. It is worth noting that IL‐41 related preparations for lung protection and smoking cessation are interesting research fields.

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Interleukin-41 diminishes cigarette smoke-induced lung inflammation in mice

Cited by 3 publications

References 24 publications

Increased serum IL‑41 associated with acute exacerbation of chronic obstructive pulmonary disease

Increased serum IL‑41 associated with acute exacerbation of chronic obstructive pulmonary disease

Interleukin-41: a novel serum marker for the diagnosis of alpha-fetoprotein-negative hepatocellular carcinoma

Homotherapy for heteropathy: Interleukin‐41 and its biological functions

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