Interleukin-39 exacerbates concanavalin A-induced liver injury

Li, Yan; Gong, Luping; Weng, Linjie; Pan, X.; Li, Mingcai

doi:10.1080/08923973.2020.1869778

Cited by 6 publications

(8 citation statements)

References 31 publications

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“…The interleulin-12 cytokine IL-39 is known to mediate inflammatory response and is implicated in immunopathogenesis of diseases such as psoriasis (17), systemic lupus erythematosus (4), myocardial infarction (18) and hepatocyte necrosis (19). This study indicated an increased level of IL-39 in RA patients (G1-G3) compared to healthy control assuming significance as results show that IL-39 probably contributes to inflammatory response in RA as seen in other disease studied.…”

Section: Discussionsupporting

confidence: 50%

An assessment of serum interleukin - 39 in rheumatoid arthritis patients from Iraq

Mohammed

Alosami²,

Alubadi³

2022

Biomedicine

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Introduction and Aim: The pro-inflammatory cytokine IL-39, a member of the IL-12 family plays a key role in the inflammatory response by modulating immune cell activity and inflammation. A literature search shows no study undertaken for the effect of IL-39's on arthritis so far. Hence, the purpose of this study was to investigate the role of IL-39 in rheumatoid arthritis. Materials and Methods: This study involved 80 patients with rheumatoid arthritis registered at the Rheumatology Clinic at Baghdad teaching hospital. The patients were divided into three groups based on treatments received. Group 1 included patients who were not on any treatment for arthritis, Group 2 with patients on hydroxychloroquine and or prednisone treatment, and Group 3 that received Enbrel® (etanercept) and HUMIRA® (adalimumab) treatment for rheumatoid arthritis. A control group was included in the study. Patients in all groups were assessed for their serum IL-39 concentration, C - reactive protein, Anti-cyclic citrullinated peptide antibody (ACCP) and ESR. Results: The patient age and BMI were not significantly different between the groups receiving treatment for Rheumatoid arthritis. A significant increase in the interleukin 39 concentration was observed in treatment groups (G1, G2, G3) as compared to normal healthy controls regardless of whether they were positive or negative for the anti-CCP test. Conclusion: This study showed that the serum interleukin IL-39 levels significantly increased in patients diagnosed with rheumatoid arthritis thus suggesting that IL-39 could be considered as a potential inflammatory biomarker of RA.

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Section: Discussionsupporting

confidence: 50%

An assessment of serum interleukin - 39 in rheumatoid arthritis patients from Iraq

Mohammed

Alosami²,

Alubadi³

2022

Biomedicine

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“…Moreover, IL‐39 levels were significantly up‐regulated in the serum of patients with neuromyelitis optica spectrum disorders compared with CTRL, and were positively correlated with disease severity 16 . Another study indicated that IL‐39 was associated with the exacerbation of concanavalin A‐induced liver inflammation, and based on this, IL‐39 was proposed as a therapeutic target in inflammatory hepatic diseases 17 . Besides, the pathogenic role of IL‐39 in acute graft‐versus‐host disease has been identified and its role in potentiating T‐lymphocyte functions has been recognized 34 .…”

Section: Discussionmentioning

confidence: 99%

“…In patients with neuromyelitis optica spectrum disorders, an inflammatory demyelinating autoimmune disorder, up‐regulated levels of IL‐39 have been demonstrated 16 . IL‐39 has also been associated with exacerbation of concanavalin A‐induced hepatitis 17 . These studies point to the potential involvement of IL‐39 in the pathogenesis of human inflammatory diseases.…”

Section: Introductionmentioning

confidence: 90%

Interleukin‐39 is a novel cytokine associated with type 2 diabetes mellitus and positively correlated with body mass index

Nussrat

Ad’hiah

2023

Endocrino Diabet & Metabol

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Introduction It is suggested that cytokines play a key role in the pathogenesis of type 2 diabetes mellitus (T2DM). Therefore, this study explored two recently discovered cytokines, interleukin (IL)‐37 (anti‐inflammatory) and IL‐39 (pro‐inflammatory), in T2DM due to limited data in this context. Methods Serum IL‐37 and IL‐39 levels were determined in 106 T2DM patients and 109 controls using enzyme‐linked immunosorbent assay kits. Results Serum levels (median and interquartile range) of IL‐37 (79 [47–102] vs. 60 [46–89] ng/L; probability [p] = .04) and IL‐39 (66 [59–69] vs. 31 [19–42] ng/L; p < .001) were significantly elevated in T2DM patients compared to controls. As indicated by the area under the curve (AUC), IL‐39 (AUC = 0.973; p < .001) was more predictable for T2DM than IL‐37 (AUC = 0.582; p = .039). Elevated levels of IL‐39 were significantly associated with T2DM (odds ratio = 1.30; p < .001), while IL‐37 did not show this association. Classification of IL‐37 and IL‐39 levels by demographic and clinical characteristics of patients revealed some significant differences including gender (IL‐39), body mass index (BMI; IL‐37 and IL‐39) and diabetic neuropathy (IL‐39). BMI was positively correlated with IL‐39 (correlation coefficient [rs] = 0.27; p = .005) and glycosylated haemoglobin (rs = 0.31; p = .001), and negatively correlated with age at onset (rs = −0.24; p = .015). Conclusions IL‐37 and IL‐39 levels were elevated in the serum of T2DM patients. Besides, IL‐39 is proposed to be a novel cytokine associated with T2DM and positively correlated with BMI.

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“…Yang et al 28 found that IL‐39 may have a pro‐inflammatory influence in the pathogenesis of neuromyelitis optica spectrum disorders and that levels of this cytokine may be associated with the severity of the disease. Our recent results revealed that IL‐39 can exacerbate concanavalin A‐induced hepatitis and may represent a therapeutic target in inflammatory liver disease 33 …”

Section: Discussionmentioning

confidence: 99%

“…Our recent results revealed that IL‐39 can exacerbate concanavalin A‐induced hepatitis and may represent a therapeutic target in inflammatory liver disease. 33 Nevertheless, the potential impact of IL‐39 in AITD has not been explored. In the current study, we measured the levels of serum IL‐39 in patients with HT and GD and found that they were significantly lower than those of HCs.…”

Section: Discussionmentioning

confidence: 99%

Low levels of serum IL‐39 are associated with autoimmune thyroid disease

Weng

Huang

Gong

et al. 2022

Clinical Laboratory Analysis

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Autoimmune thyroid disease (AITD) is a family of classic autoimmune disorders that mainly consists of Hashimoto's thyroiditis (HT) and Graves' disease (GD). 1 The global prevalence of HT is estimated at 2%. 2 A significant sign of HT is loss of self-tolerance to thyroid antigens. 3 HT is characterized by infiltration of thyroid lymphocytes, circulating thyroid autoantibodies, and apoptosis of thyroid cells leading to the destruction of follicles. 3,4 GD is an organ-specific thyroid autoimmune disease with anti-thyroid stimulating hormone (TSH) receptor (TSH-R) autoantibodies in circulation that can cause hyperthyroidism. Lack of immune tolerance to thyroid antigens, especially TSH-R, is the cause of GD. 5 It is estimated that the incidence of AITD in women is significantly higher than that in men. The prevalence of AITD is 2% in women and 0.2% in men. AITD is most common in adults aged 30-50, and the disease occurrence increases with age. 6,7 Cytokines play a crucial role in the induction and action stages of immune and inflammatory responses. Imbalances between preand anti-inflammatory cytokines may play an important role in the occurrence and development of AITD. Several cytokines, including interleukin (IL)-17, IL-23, IL-28, and IL-29, have been implicated in the pathogenesis of HT. [8][9][10][11][12][13][14] Additionally, IL-6, IL-21, IL-23, and IL-37 are all involved in the occurrence of GD. [15][16][17][18][19] IL-12 family plays a key role in immune responses through their functional, unique structural, and immunological characteristics. 20 IL-12, IL-23, IL-27, IL-35, and the recently discovered IL-39 comprise the IL-12 cytokine family. 21 Wang et al. 22,23 first reported that IL-39 is

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Interleukin-39 exacerbates concanavalin A-induced liver injury

Cited by 6 publications

References 31 publications

An assessment of serum interleukin - 39 in rheumatoid arthritis patients from Iraq

An assessment of serum interleukin - 39 in rheumatoid arthritis patients from Iraq

Interleukin‐39 is a novel cytokine associated with type 2 diabetes mellitus and positively correlated with body mass index

Low levels of serum IL‐39 are associated with autoimmune thyroid disease

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