Interleukin-37 relieves PM2.5-triggered lung injury by inhibiting autophagy through the AKT/mTOR signaling pathway in vivo and in vitro

Cao, Jing; Hou, Shujie; Chen, Zixiao; Yan, Jie; Chao, Lingshan; Qian, Yuxing; Li, Jingwen; Yan, Xixin

doi:10.1016/j.ecoenv.2023.115816

Ecotoxicology and Environmental Safety

2024

DOI: 10.1016/j.ecoenv.2023.115816

|View full text |Cite

Interleukin-37 relieves PM2.5-triggered lung injury by inhibiting autophagy through the AKT/mTOR signaling pathway in vivo and in vitro

Jing Cao,

Shujie Hou,

Zixiao Chen

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article4

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

IL‐37 possesses both anti‐inflammatory and antiviral effects against Middle East respiratory syndrome coronavirus infection

Qi,

Yan,

et al. 2024

Anim Models and Exp Med

View full text Add to dashboard Cite

BackgroundThe aim was to elucidate the function of IL‐37 in middle east respiratory syndrome coronavirus (MERS‐CoV) infection, thereby providing a novel therapeutic strategy for managing the clinical treatment of inflammatory response caused by respiratory virus infection.MethodsWe investigated the development of MERS by infecting hDPP4 mice with hCoV‐EMC (107 TCID50 [50% tissue culture infectious dose]) intranasally. We infected A549 cells with MERS‐CoV, which concurrently interfered with IL‐37, detecting the viral titer, viral load, and cytokine expression at certain points postinfection. Meanwhile, we administered IL‐37 (12.5 μg/kg) intravenously to hDPP4 mice 2 h after MERS‐CoV‐2 infection and collected the serum and lungs 5 days after infection to investigate the efficacy of IL‐37 in MERS‐CoV infection.ResultsThe viral titer of MERS‐CoV‐infected A549 cells interfering with IL‐37 was significantly reduced by 4.7‐fold, and the viral load of MERS‐CoV‐infected hDPP4 mice was decreased by 59‐fold in lung tissue. Furthermore, the administration of IL‐37 suppressed inflammatory cytokine and chemokine (monocyte chemoattractant protein 1, interferon‐γ, and IL‐17A) expression and ameliorated the infiltration of inflammatory cells in hDPP4 mice.ConclusionIL‐37 exhibits protective properties in severe pneumonia induced by MERS‐CoV infection. This effect is achieved through attenuation of lung viral load, suppression of inflammatory cytokine secretion, reduction in inflammatory cell infiltration, and mitigation of pulmonary injury.

show abstract

IL‐37 possesses both anti‐inflammatory and antiviral effects against Middle East respiratory syndrome coronavirus infection

Qi,

Yan,

et al. 2024

Anim Models and Exp Med

View full text Add to dashboard Cite

show abstract

Network pharmacology and phytochemical composition combined with validation in vivo and in vitro reveal the mechanism of platycodonis radix ameliorating PM2.5-induced acute lung injury

Han,

Zhang,

Zhang

et al. 2024

Journal of Ethnopharmacology

View full text Add to dashboard Cite

The amelioration effect of antidiabetic agents on cytokine expression in patients with type 2 diabetes mellitus

Abd El-Hameed,

Eskandrani,

Salah Abdel-Reheim

et al. 2024

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Interleukin-37 relieves PM2.5-triggered lung injury by inhibiting autophagy through the AKT/mTOR signaling pathway in vivo and in vitro

Cited by 4 publications

References 53 publications

IL‐37 possesses both anti‐inflammatory and antiviral effects against Middle East respiratory syndrome coronavirus infection

IL‐37 possesses both anti‐inflammatory and antiviral effects against Middle East respiratory syndrome coronavirus infection

Network pharmacology and phytochemical composition combined with validation in vivo and in vitro reveal the mechanism of platycodonis radix ameliorating PM2.5-induced acute lung injury

The amelioration effect of antidiabetic agents on cytokine expression in patients with type 2 diabetes mellitus

Contact Info

Product

Resources

About