Interleukin-37 ameliorates cigarette smoke-induced lung inflammation in mice

Wu, Tingting; Xu, Keye; Liu, Chaobo; Li, Yan; Li, Mingcai

doi:10.1016/j.biopha.2022.113684

Cited by 3 publications

(3 citation statements)

References 49 publications

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“…Liu et al's study found that cigarette smoke (CS) and house dust mite (HDM) exposure suppressed IL-35 level in vivo and in vitro [36] . Wu et al's study elucidated that intranasally with IL-37-expressing lentivirus signi cantly alleviated CS-induced in ammatory cell recruitment, alveolar septum enlargement and alveolar wall attenuation [14] . Chen et al's study showed that plasma IL-35 decreased in COPD patients compared to the healthy counterparts [13] .…”

Section: Discussionmentioning

confidence: 99%

“…However, little studies have focused on the effect of IL-35 and IL-37 in the pathogenesis of COPD. Although Chen et al's research found a decreased expression of IL-35 in COPD patients [13] and Wu et al discovered a signi cant role of IL-37 in suppressing cigarette smoking-induced lung in ammation [14] , more studies are needed to elucidate the effect of IL-35 and IL-37 in the progression of airway in ammation in COPD patients.…”

Section: Introductionmentioning

confidence: 96%

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Decreased serum IL-35 and IL-37 in COPD patients with severe emphysema

Yang,

Wei,

Yan

et al. 2024

Preprint

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Background Chronic obstructive pulmonary disease(COPD) is a heterogeneous syndrome and chronic persistent inflammation has been discovered to play critical role in the structural damage leading to the progression of emphysema. IL-35 and IL-37 are both immune-suppressing cytokines which exert inhibitory effects on a lot of inflammatory disorders. This study aimed to determine the correlation between serum levels of IL-35 and IL-37 with the severity of emphysema and clinical parameters of COPD patients. Methods We detected the serum levels of IL-35, IL-37 and IL-33 from 64 Chinese patients with stable COPD by using an enzyme-linked immunosorbent assay and examined the association of their concentrations with COPD patients’ clinical parameters. Results The serum levels of IL-35 and IL-37 were significantly decreased in the COPD patients with severe emphysema subtype compared to non-emphysema or mild-to-moderate emphysema subtype. The serum level of IL-35 was correlated with body mass index(BMI), modified Medical Research Council(mMRC) score and the concentrations of IL-33 and IL-37. The lower IL-35 group exhibited decreased BMI, lower FEV1/FVC, severe extent of emphysema and worse mMRC. Multivariable regression showed that lower FEV1/FVC, worse mMRC score and decreased serum levels of IL-35 were independently associated with severe emphysema. Conclusions We found that the serum IL-35 and IL-37 levels were decreased in severe emphysema subtype. The lower level of IL-35 was correlated with lower BMI and worse mMRC score. IL-35 concentrations, FEV1/FVC and mMRC score were independently associated with the extent of emphysema.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Decreased serum IL-35 and IL-37 in COPD patients with severe emphysema

Yang,

Wei,

Yan

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…(40) More clearly it has been demonstrated that cigarette smoke induces lung inflammation by various mechanisms. (41,42) As a result of exposure to filtered kretek cigarette smoke, specifically the bronchial mucosa undergoes hyperplasia. A previous study demonstrated that exposure to cigarette smoke at a dose of 2 sticks/day for 14 days caused changes in epithelial structure in rat airways.…”

Section: Discussionmentioning

confidence: 99%

Effects of low-dose filtered kretek cigarette smoke on bronchial smooth muscle in male Sprague-Dawley rats

Tjahyadi,

Parwanto,

Sisca

et al. 2023

Univ Med

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BackgroundKretek cigarettes contain less nicotine and tar than conventional cigarettes. Exposure to cigarette smoke occurs mainly in the respiratory tract, resulting in histometric changes. The aim of this study was to evaluate the effect of filtered kretek cigarette smoke on bronchial histometric measurements in male Sprague-Dawley rats. MethodsAn experimental laboratory study was conducted involving 18 male Sprague-Dawley rats, aged 2-3 months, ranging from 150 to 250 grams in body weight. They were randomized into group 1 (controls) and experimental groups 2 and 3. Group 2 was exposed to filtered cigarette smoke at a dose of 1 stick/day and group 3 to 2 sticks/day. Treatment time for all groups was 30 days. Observation of bronchial histometric measurements of the lumen include, length, width, area, and perimeter. In addition, the bronchial mucosal and smooth muscle layers were also measured. The one way-ANOVA test was used to analyze the data. ResultsThe mean area and mean perimeter of the bronchial lumen of the rats were significantly greater in group 1 than in groups 2 and 3 (p=0.000). The mean bronchial smooth muscle area of the rats in group 1 was smaller than the mean in group 2, which was in turn smaller than the mean in group 3 (p=0.000). Apparently the rats in the treatment groups had undergone bronchoconstriction. ConclusionExposure to filtered kretek cigarette smoke at a dose of 1 stick/day as well as 2 sticks/day for 30 days caused bronchial mucosal hyperplasia and bronchoconstriction in male rats.

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Single-cell sequencing reveals lung cell fate evolution initiated by smoking to explore gene predictions of correlative diseases

Lei,

2024

Toxicology Mechanisms and Methods

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Interleukin-37 ameliorates cigarette smoke-induced lung inflammation in mice

Cited by 3 publications

References 49 publications

Decreased serum IL-35 and IL-37 in COPD patients with severe emphysema

Decreased serum IL-35 and IL-37 in COPD patients with severe emphysema

Effects of low-dose filtered kretek cigarette smoke on bronchial smooth muscle in male Sprague-Dawley rats

Single-cell sequencing reveals lung cell fate evolution initiated by smoking to explore gene predictions of correlative diseases

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