Interleukin-37 ameliorates atherosclerosis by regulating autophagy-mediated endothelial cell apoptosis and inflammation

Xiao, Shengyang; Song, Xiping; Zheng, Mianping; Cao, Xinran; Ai, Guo; Li, Baona; Zhao, Gang; Yuan, Haitao

doi:10.1016/j.intimp.2023.110098

Cited by 5 publications

(1 citation statement)

References 41 publications

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“…found that the SIRT1/Beclin-1/autophagy axis can protect against LDL-induced vascular aging ( 118 ). Inflammatory activation induces endothelial dysfunction by increasing oxidative stress ( 119 ), and enhanced autophagy can alleviate inflammation and apoptosis in atherosclerotic ECs and play a cardiovascular protective role ( 120 ). However, in high glucose environments, ROS accumulation in HRGECs inhibits eNOS activity and NO bioavailability, which is related to an increase in autophagy flux ( 121 ).…”

Section: Discussionmentioning

confidence: 99%

Physiological and pathological characteristics of vascular endothelial injury in diabetes and the regulatory mechanism of autophagy

et al. 2023

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Vascular endothelial injury in diabetes mellitus (DM) is the major cause of vascular disease, which is closely related to the occurrence and development of a series of vascular complications and has a serious negative impact on a patient’s health and quality of life. The primary function of normal vascular endothelium is to function as a barrier function. However, in the presence of DM, glucose and lipid metabolism disorders, insulin resistance, inflammatory reactions, oxidative stress, and other factors cause vascular endothelial injury, leading to vascular endothelial lesions from morphology to function. Recently, numerous studies have found that autophagy plays a vital role in regulating the progression of vascular endothelial injury. Therefore, this article compares the morphology and function of normal and diabetic vascular endothelium and focuses on the current regulatory mechanisms and the important role of autophagy in diabetic vascular endothelial injury caused by different signal pathways. We aim to provide some references for future research on the mechanism of vascular endothelial injury in DM, investigate autophagy’s protective or injurious effect, and study potential drugs using autophagy as a target.

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Section: Discussionmentioning

confidence: 99%

Physiological and pathological characteristics of vascular endothelial injury in diabetes and the regulatory mechanism of autophagy

et al. 2023

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IL‐37 possesses both anti‐inflammatory and antiviral effects against Middle East respiratory syndrome coronavirus infection

Qi,

Yan,

et al. 2024

Anim Models and Exp Med

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BackgroundThe aim was to elucidate the function of IL‐37 in middle east respiratory syndrome coronavirus (MERS‐CoV) infection, thereby providing a novel therapeutic strategy for managing the clinical treatment of inflammatory response caused by respiratory virus infection.MethodsWe investigated the development of MERS by infecting hDPP4 mice with hCoV‐EMC (107 TCID50 [50% tissue culture infectious dose]) intranasally. We infected A549 cells with MERS‐CoV, which concurrently interfered with IL‐37, detecting the viral titer, viral load, and cytokine expression at certain points postinfection. Meanwhile, we administered IL‐37 (12.5 μg/kg) intravenously to hDPP4 mice 2 h after MERS‐CoV‐2 infection and collected the serum and lungs 5 days after infection to investigate the efficacy of IL‐37 in MERS‐CoV infection.ResultsThe viral titer of MERS‐CoV‐infected A549 cells interfering with IL‐37 was significantly reduced by 4.7‐fold, and the viral load of MERS‐CoV‐infected hDPP4 mice was decreased by 59‐fold in lung tissue. Furthermore, the administration of IL‐37 suppressed inflammatory cytokine and chemokine (monocyte chemoattractant protein 1, interferon‐γ, and IL‐17A) expression and ameliorated the infiltration of inflammatory cells in hDPP4 mice.ConclusionIL‐37 exhibits protective properties in severe pneumonia induced by MERS‐CoV infection. This effect is achieved through attenuation of lung viral load, suppression of inflammatory cytokine secretion, reduction in inflammatory cell infiltration, and mitigation of pulmonary injury.

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When nitrosative stress hits the endoplasmic reticulum: Possible implications in oxLDL/oxysterols-induced endothelial dysfunction

Nasoni

Crinelli

Iuliano

et al. 2023

Free Radical Biology and Medicine

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Interleukin-37 ameliorates atherosclerosis by regulating autophagy-mediated endothelial cell apoptosis and inflammation

Cited by 5 publications

References 41 publications

Physiological and pathological characteristics of vascular endothelial injury in diabetes and the regulatory mechanism of autophagy

Physiological and pathological characteristics of vascular endothelial injury in diabetes and the regulatory mechanism of autophagy

IL‐37 possesses both anti‐inflammatory and antiviral effects against Middle East respiratory syndrome coronavirus infection

When nitrosative stress hits the endoplasmic reticulum: Possible implications in oxLDL/oxysterols-induced endothelial dysfunction

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