Interleukin-37 alleviates myocardial injury induced by coxsackievirus B3 via inhibiting neutrophil extracellular traps formation

Li, Baona; Cao, Xinran; Ai, Guo; Liu, Yuanyuan; Lv, Chanyuan; Jin, Luoqing; Xu, Rong; Zhao, Gang; Yuan, Haitao

doi:10.1016/j.intimp.2022.109343

Cited by 4 publications

(3 citation statements)

References 50 publications

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Section: Impacts Of Il-37 On Immune Responsesmentioning

confidence: 98%

“… 39 Injection of coxsackievirus B3 (CVB3) into WT mice resulted in acute viral myocarditis (VMC), by which there was much production of NETs in the heart. 40 Administration of IL-37 inhibited generation of NETs, and downregulated levels of P-NF-κB P65 in heart. When neutrophils from healthy volunteers were stimulated with PMA (phorbol-12-myristat-13-acetate), there were much NETs formation.…”

Section: Introductionmentioning

confidence: 98%

“…However, generation of NETs was suppressed after addition of IL-37 or NF-κB inhibitor. 40 For role of IL-37 in NK cells, NK cells stimulated with IL-15+IL-37 promote levels of CD69, IFN-γ, GM-CSF, P-ERK, P-NF-κB P65, and promote NK cells cytotoxic activity against tumors, such as colon carcinoma cell lines HT-29, SW480 than those in IL-15-treated NK cells, revealing improvement of NK cells-mediated anti-tumor response. 41 Co-culturing human basophils with keratinocyte HaCaT cells in the presence of IL-37b downregulated thymic stromal lymphopoietin (TSLP), and lowered expression of basophil activation marker CD203c.…”

Section: Introductionmentioning

confidence: 99%

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Role of IL-1 Family Cytokines IL-36, IL-37, IL-38 in Osteoarthritis and Rheumatoid Arthritis: A Comprehensive Review

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Section: Impacts Of Il-37 On Immune Responsesmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Role of IL-1 Family Cytokines IL-36, IL-37, IL-38 in Osteoarthritis and Rheumatoid Arthritis: A Comprehensive Review

Xu,

Wang,

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et al. 2024

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Neutrophil extracellular traps in homeostasis and disease

Wang,

Kim,

Lei

et al. 2024

Sig Transduct Target Ther

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Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are renowned for their propensity to expel decondensed chromatin embedded with inflammatory proteins. Our comprehension of NETs in pathogen clearance, immune regulation and disease pathogenesis, has grown significantly in recent years. NETs are not only pivotal in the context of infections but also exhibit significant involvement in sterile inflammation. Evidence suggests that excessive accumulation of NETs can result in vessel occlusion, tissue damage, and prolonged inflammatory responses, thereby contributing to the progression and exacerbation of various pathological states. Nevertheless, NETs exhibit dual functionalities in certain pathological contexts. While NETs may act as autoantigens, aggregated NET complexes can function as inflammatory mediators by degrading proinflammatory cytokines and chemokines. The delineation of molecules and signaling pathways governing NET formation aids in refining our appreciation of NETs’ role in immune homeostasis, inflammation, autoimmune diseases, metabolic dysregulation, and cancer. In this comprehensive review, we delve into the multifaceted roles of NETs in both homeostasis and disease, whilst discussing their potential as therapeutic targets. Our aim is to enhance the understanding of the intricate functions of NETs across the spectrum from physiology to pathology.

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Role of immune cells in the pathogenesis of myocarditis

Liu,

Han

2023

Journal of Leukocyte Biology

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Myocarditis is an inflammatory heart disease that mostly affects young people. Myocarditis involves a complex immune network; however, its detailed pathogenesis is currently unclear. The diversity and plasticity of immune cells, either in the peripheral blood or in the heart, have been partially revealed in a number of previous studies involving patients and several kinds of animal models with myocarditis. It is the complexity of immune cells rather than one cell type that is the culprit. Thus, recognizing the individual intricacies within immune cells in the context of myocarditis pathogenesis and finding the key intersection of the immune network may help in the diagnosis and treatment of this condition. With the vast amount of cell data gained on myocarditis and the recent application of single-cell sequencing, we summarize the multiple functions of currently recognized key immune cells in the pathogenesis of myocarditis to provide an immune background for subsequent investigations.

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Interleukin-37 alleviates myocardial injury induced by coxsackievirus B3 via inhibiting neutrophil extracellular traps formation

Cited by 4 publications

References 50 publications

Role of IL-1 Family Cytokines IL-36, IL-37, IL-38 in Osteoarthritis and Rheumatoid Arthritis: A Comprehensive Review

Role of IL-1 Family Cytokines IL-36, IL-37, IL-38 in Osteoarthritis and Rheumatoid Arthritis: A Comprehensive Review

Neutrophil extracellular traps in homeostasis and disease

Role of immune cells in the pathogenesis of myocarditis

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