Interleukin 35 (IL-35) and IL-37: Intestinal and peripheral expression by T and B regulatory cells in patients with Inflammatory Bowel Disease

Fonseca‐Camarillo, Gabriela; Furuzawa‐Carballeda, Janette; Yamamoto-Furusho, Jesús K.

doi:10.1016/j.cyto.2015.04.009

Cited by 70 publications

(47 citation statements)

References 24 publications

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“…In patients with active SLE, serum IL-35 levels were increased with a low soluble level of IL-35 receptors on CD4 + Th 14. In patients with active ulcerative colitis, IL-35 (EBi3) mRNA levels in colonic mucosa were significantly upregulated compared with patients with inactive ulcerative colitis 15. Taken together, these results may suggest that IL-35 has an important role in the pathogenesis of disease activity in RA.…”

Section: Discussionmentioning

confidence: 82%

Elevated serum IL-35 levels in rheumatoid arthritis are associated with disease activity

Yao

Liu

et al. 2019

Journal of Investigative Medicine

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To investigate serum interleukin (IL)- 35 levels in patients with rheumatoid arthritis (RA) and to describe the association between serum IL-35 levels and clinical parameters: erythrocyte sedimentation rate (ESR), C reactive protein (CRP), global health on Visual Analog Scale, Disease Activity Score in 28 joints based on ESR (DAS28-ESR), rheumatoid factor (RF) and anticyclic citrullinated peptide antibodies (ACPAs). The study included 129 patients with RA and 83 healthy controls. Serum IL-35 levels were detected by ELISA. ESR and CRP were measured by the Westergren method and the immune transmission turbidity method, respectively. RF and ACPA were measured using immunoturbidimetric assays and chemiluminescence analysis, respectively. The results showed that serum IL-35 levels were elevated in patients with RA. Univariate and multivariate analyses showed that the high serum IL-35 levels were correlated with low ESR and DAS28-ESR. These suggested that IL-35, an important anti-inflammatory cytokine, may participate in the regulation of the pathogenesis of RA, especially with disease activity.

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Section: Discussionmentioning

confidence: 82%

Elevated serum IL-35 levels in rheumatoid arthritis are associated with disease activity

Yao

Liu

et al. 2019

Journal of Investigative Medicine

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“…One study indicated that human FOXP3 + Tregs do not constitutively express IL-35 akin to mouse Tregs 153 . However, another, more recent study reported increased expression of IL-35 by Tregs and CD20 + regulatory B cells in intestinal biopsies from active vs. inactive UC and CD patients 154 , perhaps suggesting that increased IL-35 expression in actively inflamed intestinal tissue is a homeostatic response that precedes resolution of inflammation.…”

Section: Cd4+ T Cells In Ibdmentioning

confidence: 98%

Cytokine Networks and T-Cell Subsets in Inflammatory Bowel Diseases

Chen

Sundrud

2016

Inflammatory Bowel Diseases

125

104

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Pathogenesis of the inflammatory bowel diseases (IBDs) ulcerative colitis (UC) and Crohn’s disease (CD) involve pro-inflammatory changes within the microbiota, chronic immune-mediated inflammatory responses, and epithelial dysfunction. Converging data from genome-wide association studies (GWAS), mouse models of IBD, and clinical trials indicate that cytokines are key effectors of both normal homeostasis and chronic inflammation in the gut. Yet still many questions remain concerning the role of specific cytokines in different IBDs, within distinct regions of the gut, and with regard cellular mechanisms of action. Here we review current and emerging concepts concerning the role of cytokines in IBD, with a focus on immune regulation, T cell subsets, and potential clinical applications.

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“…Multiple studies have demonstrated the important regulatory role of IL-35 in IBD. Recently, two groups showed that IL-35 levels are significantly decreased in the serum but increased in the local colon tissue, and high IL-35 secreting intestinal Breg and circulating regulatory CD4 + T and CD8 + T cells are found in patients with active IBD [63, 64]; the level of IL-35 in the serum is inversely correlated with that of the activity of UC [64]. In T cell-dependent murine colitis model, EBI3 −/− mice (lacking both IL-27 and IL-35) develop early onset and severe colitis with shorten survival time, when compared to IL-27p28 −/− mice (lacking IL-27 only) [65], while recombinant IL-35 treatment significantly limited the development of several forms of experimental colitis and decreased levels of markers of Th1 and Th17 cells [65].…”

Section: Il-12 Familymentioning

confidence: 99%

“…The percentage of IL-37-secreting cells is higher in the inflamed intestine of active CD patients than that in active ulcerative and noninflamed control tissues [63]. Levels of IL-37 in the sera are increased in active IBD patients, which are conspicuously produced by circulating B cells, active natural killer cells, and monocytes [63, 64].…”

Section: Il-1 Familymentioning

confidence: 99%

Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel Disease

Guan

Zhang

2017

Mediators of Inflammation

126

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Cytokines play an important role in the immunopathogenesis of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, where they drive and regulate multiple aspects of intestinal inflammation. The imbalance between proinflammatory and anti-inflammatory cytokines that occurs in IBD results in disease progression and tissue damage and limits the resolution of inflammation. Targeting cytokines have been novel strategies in the treatment of IBD. Recent studies show the beneficial effects of anticytokine treatments to IBD patients, and multiple novel cytokines are found to be involved in the pathogenesis of IBD. In this review, we will discuss the recent advances of novel biologics in clinics and clinical trials, and novel proinflammatory and anti-inflammatory cytokines found in IBD with focusing on IL-12 family and IL-1 family members as well as their relevance to the potential therapy of IBD.

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Interleukin 35 (IL-35) and IL-37: Intestinal and peripheral expression by T and B regulatory cells in patients with Inflammatory Bowel Disease

Cited by 70 publications

References 24 publications

Elevated serum IL-35 levels in rheumatoid arthritis are associated with disease activity

Elevated serum IL-35 levels in rheumatoid arthritis are associated with disease activity

Cytokine Networks and T-Cell Subsets in Inflammatory Bowel Diseases

Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel Disease

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