Interleukin-33 and oxidative stress in epilepsy patients

Ethemoğlu, Özlem; Çalık, Mustafa; Koyuncu, İsmail; Ethemoğlu, Kadri Burak; Göcmen, Adalet; Güzelçiçek, Ahmet; Çadirci, Dursun

doi:10.1016/j.eplepsyres.2021.106738

Cited by 17 publications

(9 citation statements)

References 40 publications

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“…IL-13 and IL-10 are derived from M2 phenotype macrophages and protect the blood-brain barrier from damage, thereby reducing cerebral edema and neurological dysfunction 15,16 . In contrast, TNF-α and IL-6 are mainly derived from M1 phenotype macrophages, which disrupt the blood-brain barrier, thereby exacerbating cerebral edema and neurological dysfunction 17,18 . MLT was shown to increase the expression of IL-33, IL-13, and IL-10, as well as decrease the expression of TNF-α and IL-6 through MT2.…”

Section: Discussionmentioning

confidence: 99%

“…On the one hand, IL-33 increases the expression of IL-10 and IL-13 by promoting M2 macrophage transformation 13,14 and, in parallel, it inhibits the expression of TNF-α and IL-6 by limiting M1 phenotype polarization 15,16 . On the other hand, IL-33's expression is negatively correlated with reactive oxygen species (ROS) activity, which can alleviate lipid peroxidative damage 17 . Lipid peroxidative damage can lead to cell death known as Ferroptosis 18,19 .…”

Section: Introductionmentioning

confidence: 99%

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Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury

Gao¹,

Wang²,

Cheng³

et al. 2023

Free Radical Biology and Medicine

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury

Gao¹,

Wang²,

Cheng³

et al. 2023

Free Radical Biology and Medicine

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“… 153 , 180 Moreover, oxidative stress index, which is significantly higher in patients not responding to antiepileptic drug treatment, was positively correlated with IL-33 levels. 182 Memory performance was also correlated with IL-33 levels in temporal lobe epilepsy. 180 In an animal model of recurrent neonatal seizures, IL-33 administration improved learning, memory, and behavior deficits, as well as body weight gain secondary to seizures by inhibition of apoptosis, endoplasmic reticulum stress, and neuroinflammation.…”

Section: Discussionmentioning

confidence: 96%

“…154 A few studies have identified a relationship between IL-33/ST2 pathway and epilepsy. 153,[180][181][182] Plasma ST2 levels were found higher in patients with increased epileptiform abnormalities after SAH, as well as patients with focal temporal lobe epilepsy. 153,180 Moreover, oxidative stress index, which is significantly higher in patients not responding to antiepileptic drug treatment, was positively correlated with IL-33 levels.…”

mentioning

confidence: 95%

Interrelationship and Sequencing of Interleukins4, 13, 31, and 33 – An Integrated Systematic Review: Dermatological and Multidisciplinary Perspectives

Tatu¹,

Nadasdy²,

Arbune³

et al. 2022

JIR

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The interrelations and sequencing of interleukins are complex (inter)actions where each interleukin can stimulate the secretion of its preceding interleukin. In this paper, we attempt to summarize the currently known roles of IL-4, IL-13, IL-31, and IL-33 from a multi-disciplinary perspective. In order to conduct a comprehensive review of the current literature, a search was conducted using PubMed, Google Scholar, Medscape, UpToDate, and Key Elsevier for keywords. The results were compiled from case reports, case series, letters, and literature review papers, and analyzed by a panel of multi-disciplinary specialist physicians for relevance. Based on 173 results, we compiled the following review of interleukin signaling and its clinical significance across a multitude of medical specialties. Interleukins are at the bed rock of a multitude of pathologies across different organ systems and understanding their role will likely lead to novel treatments and better outcomes for our patients. New interleukins are being described, and the role of this inflammatory cascade is still coming to light. We hope this multi-discipline review on the role interleukins play in current pathology assists in this scope.

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“…Epilepsy is caused by a series of complicated molecular and cellular cascades, participating in neural in ammation, apoptosis, cytokine-mediated cytotoxicity, in ammation, oxidative stress, and excitotoxicity (Uludag 2013;Ethemoglu 2021). Numerous variables contribute to the establishment of focal epilepsy and the related networks (Asadi-Pooya 2021).…”

Section: Introductionmentioning

confidence: 99%

Functional asymmetry of interleukin-1 and interleukin-6 in focal epilepsy patients

Varoğlu

Avarisli

Keskin

et al. 2022

Preprint

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Objective: In the development of epilepsy, interleukin-1 (IL-1) and interleukin-6 (IL-6) play critical roles. We sought to understand the clinical significance of IL-1 and IL-6 by comparing the blood levels of individuals with left-lateralized focal epilepsy and those with right-lateralized focal epilepsy. Method: Sixty epilepsy patients aged 18–60 with lateralized seizures and 32 healthy controls were included. Clinical and demographic data of patients were collected. We compared the levels of IL-1 and IL-6 of the patients in the interictal period. Results: Nineteen patients (31.7%) had seizures lateralized to the right hemisphere, while 41 (68.3%) were lateralized to the left hemisphere (p < 0.001). Both IL-1 and IL-6 levels were lower in all patients than in controls (p < 0.001). Both interleukin levels did not significantly differ between right and left-lateralized seizures (p = 0.44). In the left-lateralized seizures, IL-1 levels correlated with epilepsy duration (p = 0.006), onset age (p = 0.050), and prenatal risk (p = 0.028). Conclusion: Epilepsy patients had lower IL-1 and IL-6 levels than controls. In terms of these interleukins, there was no differentiation between left-lateralized seizures and right-lateralized. The number of patients with lateralized left hemispheres was higher than with the right hemispheres. IL-1 level was correlated with epilepsy duration, onset age, and prenatal risk in the left-lateralized seizures.

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Interleukin-33 and oxidative stress in epilepsy patients

Cited by 17 publications

References 40 publications

Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury

Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury

Interrelationship and Sequencing of Interleukins4, 13, 31, and 33 – An Integrated Systematic Review: Dermatological and Multidisciplinary Perspectives

Functional asymmetry of interleukin-1 and interleukin-6 in focal epilepsy patients

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