Interleukin-3 and its receptor

Lindemann, A.; Mertelsmann, Roland

doi:10.1007/978-1-4613-1241-3_5

Cited by 13 publications

(3 citation statements)

References 246 publications

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“…Since the discovery of IL-3, most in vitro studies have suggested a role for IL-3 in hematopoiesis [1][2][3][4]. Despite these studies, relatively little evidence has supported a clear role for IL-3 in hematopoiesis in vivo.…”

Section: Discussionmentioning

confidence: 99%

“…The cytokine interleukin-3 (IL-3), which can be derived from T cells and other sources, is well documented at promoting the in vitro differentiation and proliferation of murine hematopoietic progenitor cells, leading to the generation of basophils, neutrophils, macrophages, eosinophils, basophils, erythrocytes, megakaryocytes, and dendritic cells [1][2][3][4]. Administration of IL-3 to mice [5,6], experimental primates [7], and humans [1] can promote hematopoiesis in vivo as well.…”

Section: Introductionmentioning

confidence: 99%

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Absence of interleukin-3 does not affect the severity of local and systemic anaphylaxis but does enhance eosinophil infiltration in a mouse model of allergic peritonitis

et al. 2004

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Absence of interleukin-3 does not affect the severity of local and systemic anaphylaxis but does enhance eosinophil infiltration in a mouse model of allergic peritonitis

et al. 2004

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“…The cell surface antigens analyzed include HLA-DR, the receptor tyrosine kinases c-kitR (CD117) and Tie2 (CD202b), the interleukin-3 cytokine receptor (IL-3R, CD123) and CD33. Although all of these antigens have been well documented to be expressed by various classes of human hematopoietic PCs, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57 the number of studies investigating their expression by human HSCs is sparse. 58, 59, 60, 61, 62 …”

Section: Introductionmentioning

confidence: 99%

Further phenotypic characterization of the primitive lineage− CD34+CD38−CD90+CD45RA− hematopoietic stem cell/progenitor cell sub-population isolated from cord blood, mobilized peripheral blood and patients with chronic myelogenous leukemia

Wisniewski

Affer

Willshire

et al. 2011

Blood Cancer Journal

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The most primitive hematopoietic stem cell (HSC)/progenitor cell (PC) population reported to date is characterized as being Lin−CD34+CD38−CD90+CD45R. We have a long-standing interest in comparing the characteristics of hematopoietic progenitor cell populations enriched from normal subjects and patients with chronic myelogenous leukemia (CML). In order to investigate further purification of HSCs and for potential targetable differences between the very primitive normal and CML stem/PCs, we have phenotypically compared the normal and CML Lin−CD34+CD38−CD90+CD45RA− HSC/PC populations. The additional antigens analyzed were HLA-DR, the receptor tyrosine kinases c-kit and Tie2, the interleukin-3 cytokine receptor, CD33 and the activation antigen CD69, the latter of which was recently reported to be selectively elevated in cell lines expressing the Bcr-Abl tyrosine kinase. Notably, we found a strikingly low percentage of cells from the HSC/PC sub-population isolated from CML patients that were found to express the c-kit receptor (<1%) compared with the percentages of HSC/PCs expressing the c-kitR isolated from umbilical cord blood (50%) and mobilized peripheral blood (10%). Surprisingly, Tie2 receptor expression within the HSC/PC subset was extremely low from both normal and CML samples. Using in vivo transplantation studies, we provide evidence that HLA-DR, c-kitR, Tie2 and IL-3R may not be suitable markers for further partitioning of HSCs from the Lin−CD34+CD38−CD90+CD45RA− sub-population.

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Cytokines, Interferons, and Hematopoietic Growth Factors

Ekmekçioğlu

Grimm

2017

Holland‐Frei Cancer Medicine

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Overview Cytokines are important mediators of immune responses and produced by almost every cell in the body. Growth stimulatory or inhibitory cytokines could be subclassified as interleukins (ILs), lymphokines, monokines, chemokines, and hematopoietic growth factors. In cancer, certain cytokines act directly on the growth, differentiation, or survival of endothelial cells, whereas others act by attracting inflammatory cell types affecting angiogenesis or by inducing secondary cytokines or other mediators regulating angiogenesis. Proinflammatory and chemotactic cytokines influence the tumor environment and control the quantity and nature of infiltrating hematopoietic effector cells, with inhibiting or enhancing effects on tumor growth. The important role of cytokines in regulating immune responses may permit an effective immune response against the tumors or suppress the function of antigen‐presenting cells (APC). The understanding of cytokines has now emerged as complex picture of interacting stimulatory and inhibitory factors. Many of the molecules that govern this process have been cloned and have entered clinical trials. It is now clear that regulatory cytokines are characteristically pleiotropic and, at the same time, exhibit significant functional redundancy. The biologic characterization of the known clinically relevant ILs, interferons and selected growth factors, the rationale for their use in therapy for patients with cancer, and the accumulated clinical experience represent the subjects of this chapter.

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Interleukin-3 and its receptor

Cited by 13 publications

References 246 publications

Absence of interleukin-3 does not affect the severity of local and systemic anaphylaxis but does enhance eosinophil infiltration in a mouse model of allergic peritonitis

Absence of interleukin-3 does not affect the severity of local and systemic anaphylaxis but does enhance eosinophil infiltration in a mouse model of allergic peritonitis

Further phenotypic characterization of the primitive lineage− CD34+CD38−CD90+CD45RA− hematopoietic stem cell/progenitor cell sub-population isolated from cord blood, mobilized peripheral blood and patients with chronic myelogenous leukemia

Cytokines, Interferons, and Hematopoietic Growth Factors

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