Interleukin‐28B genetic variants in untreated Italian <scp>HCV</scp>‐infected patients: a multicentre study

Mottola, Leonardo; Cenderello, Giovanni; Piazzolla, Valeria; Forte, Paolo; Carretta, Vito; Mecenate, F.; Brancaccio, Giuseppina; Minisini, Rosalba; Zuin, Massimo; Terreni, N.; Monti, Monica; Colombo, Alberto; Nosotti, L.; Minerva, Nicola; Luzzitelli, Ilaria; Kostandini, Alba; Cuccorese, Giuseppe; Russello, Maurizio; Santoro, Rosanna; Mangia, Alessandra

doi:10.1111/liv.12630

Cited by 4 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The CC genotype was less common in G1 and G4 than G2 and G3 patients, and the proportions of CC patients in each HCV genotype agreed with previous estimates (De Nicola et al 2012; Falleti et al 2011; Bochud et al 2012; Mottola et al 2015). The geographic distribution of rs12979860 genotypes also agrees with previous reports, with the highest prevalence of the C allele in Asia, and the highest prevalence of the TT genotype in Latin America (Thomas et al 2009; Ge et al 2009).…”

Section: Discussionsupporting

confidence: 90%

IL28B genotype is associated with cirrhosis or transition to cirrhosis in treatment-naive patients with chronic HCV genotype 1 infection: the international observational Gen-C study

et al. 2016

Self Cite

View full text Add to dashboard Cite

Background and purposeContradictory data exist on the association between host interleukin-28B (IL28B) rs12979860 genotype and liver fibrosis in patients with chronic hepatitis C (CHC). This large, international, observational study (NCT01675427/MV25600) investigated relationships between IL28B rs12979860 genotype and liver fibrosis stage in CHC patients.MethodsA total of 3003 adult, treatment-naive CHC patients were enrolled into the study. Patients made one study visit to provide a blood sample for genotyping; other data were obtained from medical records.Results2916 patients comprised the analysis population; the majority were enrolled in Europe (n = 2119), were Caucasian (n = 2582) and had hepatitis C virus (HCV) genotype (G)1 infection (n = 1702) (G2 = 323, G3 = 574, G4 = 260). Distribution of IL28B genotypes varied according to region of enrolment, patient ethnicity and HCV genotype. A significant association was observed between increasing number of IL28B T alleles and the prevalence of cirrhosis/transition to cirrhosis (based on biopsy or non-invasive assessments) in G1-infected patients (CC = 22.2% [111/499], CT = 27.5% [255/928], TT = 32.3% [87/269]; p = 0.0018). The association was significant in the large subgroup of European Caucasian G1 patients (n = 1245) but not in the smaller Asian (n = 25), Latin American (n = 137) or Middle Eastern (n = 289) G1 subgroups. IL28B genotype was not associated with liver fibrosis stage in patients with HCV G2, G3 or G4 infection.ConclusionThis large, international study found that IL28B rs12979860 genotype is significantly associated with liver fibrosis stage in CHC patients with HCV G1 infection. This association was evident in European Caucasians but not in G1-infected patients from Asia, Latin America or the Middle East.Electronic supplementary materialThe online version of this article (doi:10.1186/s40064-016-3663-6) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionsupporting

confidence: 90%

IL28B genotype is associated with cirrhosis or transition to cirrhosis in treatment-naive patients with chronic HCV genotype 1 infection: the international observational Gen-C study

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…In particular, favourable genotype IL28B CC appear to be most frequently observed in genotypes HCV2 and HCV3 than in genotype HCV1 [11][12][13][14][15][16]. According to a recent study [17] on Italian patients, the frequency of IL28BCC in individuals with HCV1 resulted similar to those with HCV4 (28.4 and 24.2 % respectively).…”

Section: Introductionmentioning

confidence: 49%

Distribution of IL28B Polymorphism in a Cohort of Italians and Immigrants with HCV Infection: Association with Viraemia, Stage of Fibrosis and Response to Treatment

Nosotti¹,

Petrelli²,

Genovese³

et al. 2016

J Immigrant Minority Health

View full text Add to dashboard Cite

Aims of the study are to investigate, in a cohort of patients affected by HCV chronic hepatitis with genotypes 1 and 4, the prevalence of interleukin 28B (IL28B) genotypes, the possible association between IL28B polymorphism and severity of liver damage, the role of IL28B CC as a predictor of outcome. 365 patients with HCV infection were observed between 2013 and 2014. Demographic, virological, biochemical, and genetic characteristics of each patient were investigated. Liver fibrosis was assessed by transient elastometry. Mean age of the patients (72.9 % males, 27.1 % females) is 50 years. 91.5 % % of patients are Caucasian, 8.5 % African. In the patients with HCV1 and HCV4 a higher frequency of IL28B CT is observed with a prevalence of 52.1 and 61.8 % respectively. As regards ethnic group, African people have a prevalence of 35.5 % for CC, while Caucasians have a prevalence of 23.8 % for CC. In our cohort, IL28B polymorphism does not show significant differences among ethnic groups and in HCV1 and HCV4 genotypes. As described in literature, IL28B CC genotype is confirmed as predictor of sustained virological response in both Caucasians and Africans. A significant correlation between liver fibrosis and IL28B polymorphism emerges.

show abstract

“…The IFNL family first classically included 3 genes ( IFNL1 , IFNL2 and IFNL3 ). IL28B has been demonstrated in the inhibition of HCV replication in vivo and in vitro . Recently, Prokunina reported a new gene involved in the progression of HCV infection, known as IFN λ 4 ( IFNL4 ), also located within the IFNL locus.…”

Section: Introductionmentioning

confidence: 99%

Role of Functional IFNL4,IFNLR1,IFNA, IFNAR2 Polymorphisms in Hepatitis B virus‐related liver disease in Han Chinese population

Zhang

Yang

et al. 2017

Journal of Viral Hepatitis

View full text Add to dashboard Cite

Recent studies show that variants in some interferon genes together with interferon receptor genes are associated with the outcome of infectious diseases. We examined the association between the risk of hepatitis B virus (HBV)-related liver disease and the functional polymorphisms within IFNL4, IFNLR1, IFNA1, IFNA2, IFNA5 and IFNAR2 genes (14 loci in all) in a Han Chinese population. A total of 3128 people participated and were divided into 5 groups: healthy controls, natural clearance, chronic hepatitis B(CHB), liver cirrhosis and hepatocellular carcinoma (HCC). Significant associations were observed for 4 variants in IFNAR2, IFNLR1 with HBV infection, and IFNLR1-rs4649203 was associated with HBV recovery. Moreover, we demonstrated the clear relevance of 5 polymorphisms in IFNA1, IFNA2, IFNL4 with HCC. Three SNPs in IFNL4 gene may be important susceptible factors for the progression of HBV-related liver disease by trend chi-square test. The IFNL4 haplotype conformed by rs12971396_G, rs8113007_T and rs7248668A was more frequent in HCC than CHB and LC group. Three polymorphisms in the 5' region of the IFNL4 gene are associated with the progression of HBV-related liver disease. IFNA1- rs1831583 and IFNA2- rs649053 are associated with the development of HCC. IFNLR1- rs4649203, rs7525481 are predictors for HBV infection, and rs4649203 is a predictor of spontaneous clearance. IFNAR2 -rs1051393, rs12233338 may be predictive markers of HBV infection in the Chinese population.

show abstract

Interleukin‐28B genetic variants in untreated Italian HCV‐infected patients: a multicentre study

Cited by 4 publications

References 30 publications

IL28B genotype is associated with cirrhosis or transition to cirrhosis in treatment-naive patients with chronic HCV genotype 1 infection: the international observational Gen-C study

IL28B genotype is associated with cirrhosis or transition to cirrhosis in treatment-naive patients with chronic HCV genotype 1 infection: the international observational Gen-C study

Distribution of IL28B Polymorphism in a Cohort of Italians and Immigrants with HCV Infection: Association with Viraemia, Stage of Fibrosis and Response to Treatment

Role of Functional IFNL4,IFNLR1,IFNA, IFNAR2 Polymorphisms in Hepatitis B virus‐related liver disease in Han Chinese population

Contact Info

Product

Resources

About