Interleukin 27 (IL-27): A Novel Pleiotropic Cytokine Involved in T Cell Differentiation and T Cell Response Modulation

Petrarca, Claudia; Frydas, S.; Donelan, Jill; Boucher, William; Papadopoulou, Nikoletta; Cao, Jiang; Castellani, M.L.; Conti, Paolo; Toniato, E; Robuffo, Iole; Vecchiet, Jacopo; Iezzi, T; Madhappan, B; Kempuraj, D

doi:10.1177/039463200501800201

Cited by 13 publications

(5 citation statements)

References 38 publications

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“…They mediate all these processes through the release of various mediators: histamine, proteases (tryptase, chymase), proteoglycans and prostaglandin D2. They also produce leukotrienes, whose receptors are expressed on rat microglia [17], and several multifunctional cytokines [18][19][20][21] and chemokines [22,23]. Cytokines and chemokines are implicated in inflammation of the central nervous system [24].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of quercetin on tryptase and interleukin-6 release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line

et al. 2006

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Mast cells are involved in inflammatory processes and in allergic reactions where immunologic stimulation leads to degranulation and generation of numerous cytokines and inflammatory mediators. Mast cells have been proposed as an immune gate to the brain, as well as sensors of environmental and emotional stress, and are likely involved in neuropathologic processes such as multiple sclerosis. Among mast cell products, the protease tryptase could be associated with neurodegenerative processes through the activation of specific receptors (PARs) expressed in the brain, while interleukin (IL)-6 likely causes neurodegeneration and exacerbates dysfunction induced by other cytokines; or it could have a protective effect against demyelinisation. In this report we show that quercetin, a natural compound able to act as an inhibitor of mast cell secretion, causes a decrease in the release of tryptase and IL-6 and the down-regulation of histidine decarboxylase (HDC) mRNA from human mast cell (HMC)-1 cells. As quercetin dramatically inhibits mast cell tryptase and IL-6 release and HDC mRNA transcription by HMC-1 cell line, these results nominate quercetin as a therapeutical compound in association with other therapeutical molecules for neurological diseases mediated by mast cell degranulation.

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Section: Introductionmentioning

confidence: 99%

Inhibitory effect of quercetin on tryptase and interleukin-6 release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line

et al. 2006

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“…31,40 During treatment, decreasing PCT levels reflected defervescence, rapid or gradual clinical improvement and successful anti-microbial therapy, irrespective of the kind of bacterial infection. [49][50][51][52][53][54][55] The PCT concentration was higher in microbial infected than in non-microbial infected patients through the study period (P<0.001). The admission values of CRP were higher in the neutropenic leukemic patients with infection than in leukemic patients without infection .…”

Section: Discussionmentioning

confidence: 93%

Serial procalcitonin responses in infection of children with secondary immunodeficiency

Hatzistilianou

Rekleity

Athanassiadou

et al. 2007

CIM

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Purpose: Procalcitonin has proven to be a sensitive inflammatory marker in non-neutropenic patients. The aim of this study was to determine and compare Procalcitonin with other inflammatory markers in the serum of immunosuppressed children with haematological malignancies; and to assess the predictive value of these mediators in distinguishing between bacterial and non-bacterial infection. Methods & Results: The study included 37 children with acute lymphoblastic leukaemia undergoing intensive chemotherapy. They were divided into 3 groups, A, B and C. Group A consisted of 29 neutropenic children with 94 febrile episodes, group B of 20 neutropenic children with 56 afebrile episodes and group C of 13 non-neutropenic children with 58 afebrile episodes. Serial serum levels of PCT, C-Reactive Protein, Neopterin, Interleukin-6 and NO2/NO3 were all determined on a day-to-day basis for 7 consecutive days. In serum the concentrations of CRP was determined by nephelometry, of PCT by immunoluminescence and of Neopterin, IL-6 and NO2/NO3 by ELISA method. Conclusions: According to our results the Procalcitonin concentration increased rapidly in patients with microbial infection; the response was detectable within 24 hs of the onset of fever due to microbial infections. Procalcitonin is a spesific and sensitive marker of microbial infection in patients with neutropenic fever. The markers, C-Reactive Protein, Interleukin-6 and NO2/NO3 may not help to identify infections and distinguishe the etiology of infection in neutropenic febrile children with acute lymphoblastic leukaemia.

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“…Furthermore, the immune response of those patients may be better fine-tuned than that of patients with chronic hepatitis C, leading to a more effective control of the infection [6]. There is suggestive evidence that T-cell immunoregulatory cytokines may play a key role in the persistence of HCV infection and may influence the extent of liver damage [15,29,[32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Occult hepatitis C infection

Gad¹,

Mousa²,

Farag³

et al. 2012

Egyptian Liver Journal

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Background/aimThe immunopathogenesis of occult hepatitis C virus (HCV) infection is a matter of great controversy and has been suggested to involve a complex balance between cytokines with proinflammatory and anti-inflammatory activity. This work aimed at studying the production of serum Th1 and Th2 cytokines in patients with occult HCV infection. MethodsSerum levels of cytokines Th1 [interleukin-2 (IL-2) and interferon-g (IFN-g)] and Th2 (IL-4) were measured in 27 patients with occult HCV infection and in 28 patients with chronic hepatitis C infection. ResultsThe levels of IL-2 and IFN-g were highly significantly increased in patients with chronic HCV infection (Po0.001). In contrast, IL-4 showed a highly significant increase in occult HCV infection (Po0.001). Significant increases were noted in chronic HCV infection with respect to bilirubin (Po0.001), alanine transaminase (P = 0.009), aspartate transaminase (P = 0.013) and alfa-fetoprotein (Po0.001) levels, whereas the level of serum albumin was significantly higher in occult HCV infection (Po0.001). The degree of necroinflammation (Po0.001), fibrosis (Po0.001) and cirrhosis (P = 0.03) was significantly increased during chronic HCV infection. ConclusionOur data revealed a high prevalence of occult HCV infection (25%) in patients with unexplained persistently abnormal liver function test results. These patients exhibited a distinct immunoregulatory cytokine pattern, favouring viral persistence and explaining the less-aggressive course of this disease entity compared with chronic HCV infection.

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Interleukin 27 (IL-27): A Novel Pleiotropic Cytokine Involved in T Cell Differentiation and T Cell Response Modulation

Cited by 13 publications

References 38 publications

Inhibitory effect of quercetin on tryptase and interleukin-6 release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line

Inhibitory effect of quercetin on tryptase and interleukin-6 release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line

Serial procalcitonin responses in infection of children with secondary immunodeficiency

Occult hepatitis C infection

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