Interleukin-27 gene variant rs153109 is associated with enhanced cytokine serum levels and susceptibility to Behçet's disease in the Iranian population
“…28 The polymorphisms of IL- polymorphism was correlated with the susceptibility to ulcerative colitis (UC), rheumatoid arthritis and so on. [16][17][18]29,30 Up to now, research on the correlation of IL-27 rs153109 and aplastic anemia is limited. Based on these, we explored the relationship between IL-27 rs153109 and susceptibility and prognosis of aplastic anemia.…”
Section: Discussionmentioning
confidence: 99%
“…IL-27 gene has several SNPs, and among of these, rs153109 polymorphism has been verified to be related with the susceptibility to several inflammatory diseases, such as asthma, Behcet's disease, and systemic lupus erythematosus. [16][17][18] Moreover, Li et al 19 reported that IL-27 levels of patients with aplastic anemia were remarkably elevated than healthy normal controls. Considering the pleiotropic character of IL-27 in immune response, we speculated that IL-27 polymorphism might influence the production of IL-27 and facilitate onset of aplastic anemia.…”
Aplastic anemia, an uncommon and life-threatening blood disorder, is featured by pancytopenia and trilineage bone marrow (BM) aplasia. 1 Aplastic anemia is considered as a special autoimmune disease that targeting the BM. Aberrant immunity, mainly autoreactive T lymphocytes attacking on hemopoietic progenitor cells, has been considered to play indispensably crucial roles in the pathogenesis of aplastic anemia. [1][2][3][4] Abnormally polarized Th1 cells, elevated Th17 cells, and activated CD8 + cytotoxic T cells were proven to be involved in the immune-mediated damage of hematopoiesis by the following two ways: indirect induction of hematopoietic cells apoptosis by excessively releasing hematopoietic negative regulators, such as interferon (IFN)γ and tumor necrosis factor (TNF)α; and direct damage to autologous hematopoietic stem cells. [4][5][6][7] Further analysis confirmed that regulatory T cells (Tregs) and other cytokines, for
“…28 The polymorphisms of IL- polymorphism was correlated with the susceptibility to ulcerative colitis (UC), rheumatoid arthritis and so on. [16][17][18]29,30 Up to now, research on the correlation of IL-27 rs153109 and aplastic anemia is limited. Based on these, we explored the relationship between IL-27 rs153109 and susceptibility and prognosis of aplastic anemia.…”
Section: Discussionmentioning
confidence: 99%
“…IL-27 gene has several SNPs, and among of these, rs153109 polymorphism has been verified to be related with the susceptibility to several inflammatory diseases, such as asthma, Behcet's disease, and systemic lupus erythematosus. [16][17][18] Moreover, Li et al 19 reported that IL-27 levels of patients with aplastic anemia were remarkably elevated than healthy normal controls. Considering the pleiotropic character of IL-27 in immune response, we speculated that IL-27 polymorphism might influence the production of IL-27 and facilitate onset of aplastic anemia.…”
Aplastic anemia, an uncommon and life-threatening blood disorder, is featured by pancytopenia and trilineage bone marrow (BM) aplasia. 1 Aplastic anemia is considered as a special autoimmune disease that targeting the BM. Aberrant immunity, mainly autoreactive T lymphocytes attacking on hemopoietic progenitor cells, has been considered to play indispensably crucial roles in the pathogenesis of aplastic anemia. [1][2][3][4] Abnormally polarized Th1 cells, elevated Th17 cells, and activated CD8 + cytotoxic T cells were proven to be involved in the immune-mediated damage of hematopoiesis by the following two ways: indirect induction of hematopoietic cells apoptosis by excessively releasing hematopoietic negative regulators, such as interferon (IFN)γ and tumor necrosis factor (TNF)α; and direct damage to autologous hematopoietic stem cells. [4][5][6][7] Further analysis confirmed that regulatory T cells (Tregs) and other cytokines, for
“…Similarly, another study in patients with BD from a Southern Chinese Han population (treated with prednisone) showed that serum IL-27 levels were upregulated after cataract surgery in patients with BD, and serum levels of IL-27 were related to aqueous flare values and cell counts ( 135 ). In contrast, a study discussed the serum levels of IL-27 from an Iranian population, showing the higher expression of IL-27 in patients with BD than that in healthy controls ( 136 ). Differences between the different expression of IL-27 in patients with BD may correlate with treatment, sample size, and distinct ethnicity.…”
Section: Association Of Il-27 and Inflammatory Autoimmune Diseasesmentioning
Interleukin-27 (IL-27) is a member of the IL-12 family. The gene encoding IL-27 is located at chromosome 16p11. IL-27 is considered as a heterodimeric cytokine, which consists of Epstein–Barr virus (EBV)-induced gene 3 (Ebi3) and IL-27p28. Based on the function of IL-27, it binds to receptor IL-27rα or gp130 and then regulates downstream cascade. To date, findings show that the expression of IL-27 is abnormal in different inflammatory autoimmune diseases (including systemic lupus erythematosus, rheumatoid arthritis, Sjogren syndrome, Behcet’s disease, inflammatory bowel disease, multiple sclerosis, systemic sclerosis, type 1 diabetes, Vogt–Koyanagi–Harada, and ankylosing spondylitis). Moreover, in vivo and in vitro studies demonstrated that IL-27 is significantly in3volved in the development of these diseases by regulating innate and adaptive immune responses, playing either an anti-inflammatory or a pro-inflammatory role. In this review, we comprehensively summarized information about IL-27 and autoimmunity based on available evidence. It is hoped that targeting IL-27 will hold great promise in the treatment of inflammatory autoimmune disorders in the future.
“…BD, a chronic multi-system autoimmune disease, is characterized by a chronic, relapsing remitting course of clinical manifestations, such as skin rash, oral/genital ulcers ( Akiyama et al, 2020 ; Gholijani et al, 2020 ). In 2021, Yildiz et al (2021) finds that the total prevalence of BD worldwide is 10.3 per 100,000.…”
Section: The Function Role Of Il-38 In Autoimmune Diseasesmentioning
Interleukin-38 (IL-38), a new cytokine of interleukin-1 family (IL-1F), is expressed in the human heart, kidney, skin, etc. Recently, new evidence indicated that IL-38 is involved in the process of different autoimmune diseases. Autoimmune diseases are a cluster of diseases accompanied with tissue damage caused by autoimmune reactions, including rheumatoid arthritis (RA), psoriasis, etc. This review summarized the links between IL-38 and autoimmune diseases, as well as the latest knowledge about the function and regulatory mechanism of IL-38 in autoimmune diseases. Especially, this review focused on the differentiation of immune cells and explore future prospects, such as the application of IL-38 in new technologies. Understanding the function of IL-38 is helpful to shed light on the progress of autoimmune diseases.
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