Interleukin-22 Treatment Promotes Intestinal Stem Cell-Mediated Epithelial Regeneration Via Stat3 Activation and Reduces GI Gvhd

Lindemans, Caroline A.; Calafiore, Marco; O'Connor, Margaret; Mertelsmann, Anna; Brink, Marcel R.M. van den; Hanash, Alan M.

doi:10.1016/j.bbmt.2015.11.345

Cited by 1 publication

(1 citation statement)

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“…Accumulating evidence through studies on mice suggest that IL-22 mediated liver regeneration is carried out in collaboration with IL-6 and TGF-α signaling cascades ( 135 ). Similarly, IL-22 induced STAT3 triggering activates intestinal stem cells to regenerate epithelium ( 136 , 137 ). Up-regulated IL-22 expression during thymic recovery allows for the renewal and regeneration of thymus ( 48 ).…”

Section: Il-22 Biological Effectsmentioning

confidence: 99%

A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration

et al. 2020

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Wound healing and tissue regeneration is an intricate biological process that involves repair of cellular damage and maintenance of tissue integrity. Cascades involved in wound healing and tissue regeneration highly overlap with cancer causing pathways. Usually, subsequent tissue damage events include release of a number of cytokines to accomplish post-trauma restoration. IL-22 is one of the cytokines that are immediately produced to initiate immune response against several tissue impairments. IL-22 is a fundamental mediator in inflammation, mucous production, protective role against pathogens, wound healing, and tissue regeneration. However, accumulating evidence suggests pivotal role of IL-22 in instigation of various cancers due to its pro-inflammatory and tissue repairing activity. In this review, we summarize how healing effects of IL-22, when executed in an uncontrollable fashion can lead to carcinogenesis.

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