Interleukin-22 promotes tumor angiogenesis

Protopsaltis, Nicholas J.; Liang, Wei; Nudleman, Eric; Ferrara, Napoleone

doi:10.1007/s10456-018-9658-x

Cited by 77 publications

(56 citation statements)

References 43 publications

(54 reference statements)

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“…The classic 'Th-17-like' inflammatory response to damaged epithelial junctions in tumor cells exacerbates tumor growth and progression (43). IL-22 and IL-32 are important agents in the 'Th-17 like' inflammatory response and have recently been demonstrated to be closely associated with tumor angiogenesis (44,45). Collectively, these findings reveal a complex relationship between cancer-associated inflammation, tumorigenesis and tumor progression, which are mutually causal and reinforcing.…”

Section: Discussionmentioning

confidence: 99%

Combination of preoperative fibrinogen concentration and neutrophil‑to‑lymphocyte ratio for prediction of the prognosis of patients with resectable breast cancer

et al. 2020

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Previous studies have demonstrated that the combination of high preoperative fibrinogen levels and high neutrophil-to-lymphocyte ratio (NLR) is associated with poor outcomes in various types of cancer. The present study assessed the prognostic value of a scoring system based on the combination of fibrinogen concentration and neutrophil-to-lymphocyte ratio (F-NLR) in untreated patients with resectable breast cancer (BC). The present study retrospectively analyzed 906 patients who received surgery for resectable BC. Univariate and multivariate analyses were performed to explore the association between the F-NLR score and survival status. The cutoff values for fibrinogen and NLR determined via receiver operating characteristic curve analysis were 3.21 g/l and 2.20, respectively. On the basis of these cutoff values, the whole cohort was divided into three groups according to their F-NLR score: Score 2, fibrinogen ≥3.21 g/l and NLR ≥2.20; score 1, fibrinogen ≥3.21 g/l or NLR ≥2.20; and score 0, fibrinogen <3.21 g/l and NLR <2.20. The F-NLR score was significantly associated with age (≤50 years vs. >50 years; P<0.001), tumor size (≤2 cm vs. >2 cm; P=0.001), lymph node status (P=0.029), TNM stage (I vs. II vs. III; P= 0.002) and lymphovascular invasion (P<0.001). The 5-year disease-free survival (DFS) rates in the patients with F-NLR scores of 0, 1 and 2 were 95.7, 87.5 and 74.0%, respectively (P<0.001), and the 5-year overall survival (OS) rates were 97.8, 90.9 and 79.9%, respectively (P<0.001). Furthermore, multivariate analysis demonstrated that the F-NLR score independently predicted DFS [hazard ratio (HR), 2.279; 95% CI, 1.758-2.954; P<0.001] and OS (HR, 2.414; 95% CI, 1.738-3.353; P<0.001). In conclusion, the preoperative F-NLR score was an independent prognostic indicator for untreated patients with resectable BC.

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Section: Discussionmentioning

confidence: 99%

Combination of preoperative fibrinogen concentration and neutrophil‑to‑lymphocyte ratio for prediction of the prognosis of patients with resectable breast cancer

et al. 2020

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“…This was further supported by our data which showed decreased inflammation (no TNFα staining) in the histological sections of the EFP containing our cryogel‐0.25 wt%CPO bioscaffolds. When we compared the EFP from animals which received cryogel‐0.25 wt%CPO bioscaffolds to those which had cryogel alone bioscaffolds, there was a significant increase in the expression of IL‐2259 (i.e., a cytokine which promotes angiogenesis), LIF60 (i.e., a cytokine which regulates microvessel density), and a significant decrease in expression of IL28,61 IL‐17α,62 and TNF‐α58 (i.e., proinflammatory cytokines). However, the decreased efficiency of islet transplantation in our control experiments (i.e., islets alone transplanted into the EFP) compared to previous studies50,63,64 can be attributed to i) the use of 500 islets with islet diameters in the range of 50–150 µm—this is less than 500 islet equivalents or islet equivalent (IEQ) used in previous studies50,63,64 (one IEQ is considered equivalent to an islet with a diameter of 150 µm) and ii) our animals exhibited a higher initial blood glucose at the day of transplantation (i.e., 538 ± 25 mg dL −1 ) when compared to the above mentioned studies (i.e., 250 or 350 or 500 mg dL −1 )50,63,64—this would mean that our animals had a greater degree of dysglycemia and hence are much more dependent on the success of their islet transplant.…”

Section: Discussionmentioning

confidence: 99%

A Collagen Based Cryogel Bioscaffold that Generates Oxygen for Islet Transplantation

Razavi

Primavera

Kevadiya

et al. 2020

Adv Funct Materials

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The aim of this article is to develop, characterize, and test a novel 3D bioscaffold matrix that can accommodate pancreatic islets and provide them with a continuous, controlled, and steady source of oxygen to prevent hypoxia-induced damage following transplantation. Hence, a collagen-based cryogel bioscaffold that incorporates calcium peroxide (CPO) into its matrix is made. The optimal concentration of CPO integrated into bioscaffolds is 0.25 wt% and this generates oxygen at 0.21 ± 0.02 × 10 -3 m day -1 (day 1), 0.19 ± 0.01 × 10 -3 m day -1 (day 6), 0.13 ± 0.03 × 10 -3 m d -1 (day 14), and 0.14 ± 0.02 × 10 -3 m d -1 (day 21). Accordingly, islets seeded into cryogel-CPO bioscaffolds have a significantly higher viability and function compared to islets seeded into cryogel alone bioscaffolds; these findings are supported by data from quantitative computational modeling. When syngeneic islets are transplanted into the epididymal fat pad (EFP) of diabetic mice, the cryogel-0.25 wt%CPO bioscaffold improves islet function with diabetic animals re-establishing glycemic control. Mice transplanted with cryogel-0.25 wt%CPO bioscaffolds show faster responses to intraperitoneal glucose injections and have a higher level of insulin content in their EFP compared to those transplanted with islets alone (P < 0.05). The novel oxygen-generating bioscaffold (i.e., cryogel-0.25 wt%CPO) therefore provides a biostable and biocompatible 3D microenvironment for islets which can facilitate islet survival and function at extra-hepatic sites of transplantation.

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“…After the functional enrichment analysis, we found that some enriched biological processes were reported to be associated with tumor progression. For example, i) cell adhesion was usually reported to show a reduced number of tumor cells since 1962 (Holmberg 1962); ii) autophagic cell death occurs via the activation of autophagy, which has been reported to play roles in tumor suppression (Mathew et al 2009); iii) the positive regulation of cell proliferation is a common characteristic of cancer, and the inhibition of cancer cell proliferation may serve as a potential target for cancer treatment (He et al 2018); iv) changes in extracellular matrix organization were reported with crucial roles in cancer metastasis (Goreczny et al 2017;Sada et al 2016); v) positive regulation of blood coagulation was frequently reported in cancer progression (Tikhomirova et al 2016); and vi) angiogenesis is still considered a common characteristic of tumorigenesis in many studies (Baltrunaite et al 2017;Protopsaltis et al 2019;Ziegler et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Peer Review #1 of "Urine proteome changes in rats subcutaneously inoculated with approximately ten tumor cells (v0.1)"

2019

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Background: Biomarkers are changes associated with the disease. Urine is not subject to homeostatic control and therefore accumulates very early changes, making it an ideal biomarker source. Usually, we have performed urinary biomarker studies involving at least thousands of tumor cells. However, no tumor starts from a thousand tumor cells. We therefore examined urine proteome changes in rats subcutaneously inoculated with approximately ten tumor cells. Methods: Here, we serially diluted Walker-256 carcinosarcoma cells to a concentration of 10 2 /mL and subcutaneously inoculated 0.1 mL of these cells into nine rats. The Urine proteomes on days 0, 13 and 21 were analyzed by liquid chromatography coupled with tandem mass spectrometry. Results: Hierarchical clustering analysis showed that the urine proteome of each sample at three time points were clustered into three clusters, indicating the good consistency of these nine rats when inoculated with the same limited tumor cells. Differential proteins on days 13 and 21 were mainly associated with cell adhesion, autophagic cell death, changes in extracellular matrix organization, angiogenesis, and the pentose phosphate pathway. All of these enriched functional processes were reported to contribute to tumor progression and could not be enriched through random allocation analysis. Conclusions: Our results indicated that 1) the urine proteome reflects changes associated with cancer even with only approximately ten tumor cells in the body and that 2) the urine proteome reflects pathophysiological changes in the body with extremely high sensitivity and provides potential for a very early screening process of clinical patients.

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Interleukin-22 promotes tumor angiogenesis

Cited by 77 publications

References 43 publications

Combination of preoperative fibrinogen concentration and neutrophil‑to‑lymphocyte ratio for prediction of the prognosis of patients with resectable breast cancer

Combination of preoperative fibrinogen concentration and neutrophil‑to‑lymphocyte ratio for prediction of the prognosis of patients with resectable breast cancer

A Collagen Based Cryogel Bioscaffold that Generates Oxygen for Islet Transplantation

Peer Review #1 of "Urine proteome changes in rats subcutaneously inoculated with approximately ten tumor cells (v0.1)"

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