Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid

Martin, Jérôme C.; Bériou, Gaëlle; Heslan, Michèle; Chauvin, Céline; Utriainen, Lotta; Aumeunier, Aude; Scott, Charlotte; Mowat, Allan McI; Cerovic, Vuk; Houston, Stephanie; Leboeuf, Marylène; Hubert, François Xavier; Hémont, Caroline; Mérad, Miriam; Milling, Simon; Josien, Régis

doi:10.1038/mi.2013.28

Cited by 127 publications

(162 citation statements)

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“…Compared with the first receptor, IL-22R1, certain studies reported that the binding of IL-22 to IL-22BP has a 20-1,000-fold higher affinity (22,23); therefore the structure and biological functions of IL-22BP are of value for additional studies. One study revealed that colon tumor development was strongly accelerated and the diameter of tumors was increased in IL-22BP-/-using a colitis-associated colon cancer mice model, and showed that low expression of IL-22BP may be important in colon tumor progression (36). These results suggest that IL-22BP may perform important, complex functions in tumor development, but its role in GA is less understood.…”

mentioning

confidence: 97%

“…Although the biological functions of CXCR2 have been investigated widely, the role of CXCR2 for GA tumorigenesis has not been clarified in detail. IL-22BP, the second IL-22 receptor, is a soluble-secreted receptor that belongs to the IL-10 cytokine family (36,37). Compared with the first receptor, IL-22R1, certain studies reported that the binding of IL-22 to IL-22BP has a 20-1,000-fold higher affinity (22,23); therefore the structure and biological functions of IL-22BP are of value for additional studies.…”

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confidence: 99%

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Association between CXCR2 and IL-22BP expression indicate a poor outcome for gastric adenocarcinoma progression

Yang

Han

et al. 2016

Oncology Letters

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Abstract. C-X-C motif chemokine receptor type 2 (CXCR2), a key regulatory protein, has been associated with multiple roles in the progression of numerous tumors, including gastric adenocarcinoma (GA). However, the mechanism of CXCR2 in the development of tumors remains controversial and unclear. In a previous study, the expression of CXCR2 and interleukin-22 receptor 2 (IL-22BP) was observed in GA. This promoted the present study, which aimed to explore the association between the two proteins, and to further analyze their roles in GA. CXCR2 and IL-22BP protein expression was analyzed by immunohistochemistry and reverse transcription-quantitative polymerase chain reaction assays in gastric cancer (GC) tissue, additionally confirmed via western blotting and immunocytochemical analysis in the MKN-45, BGC-823 and SGC-7901 cell lines. The association between expression levels and clinicopathological characteristics was evaluated by the Mann-Whitney U and Kruskal-Wallis tests. Using Kaplan-Meier plots and Cox proportional hazard models, overall survival (OS) was analyzed. Compared with non-cancerous tissue, CXCR2 and IL-22BP were over expressed (P<0.001 and P<0.001, respectively), and were observed mainly in the cytoplasm (P=0.022 and P=0.014, respectively) in GA. The associated protein and messenger RNA levels were analyzed, and coexpression was identified. Increased expression and more positive cases of CXCR2 and IL-22BP were observed with advanced pathological tumor-node-metastasis (p-TNM) stage in GC (P<0.001 and P<0.001, respectively), as well as the presence and absence of lymph node metastasis (LNM) (P=0.003 and P=0.041, respectively) and deep or superficial muscular invasion (P=0.002 and P=0.004, respectively). In addition, an association between IL-22BP and tumor diameter was indicated (P=0.021). In a Kaplan-Meier analysis, compared with negative expression, the two proteins identified a group of patients with the shortest OS. Cox proportional hazard models revealed that the two proteins, in addition to p-TNM stage, LNM and depth of invasion, predicted a short time to OS. The coexpression of CXCR2 and IL-22BP was demonstrated in GA, which may indicate that CXCR2 is involved in more complex mechanisms and roles, and indicate a poor outcome in GA progression.

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confidence: 97%

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confidence: 99%

Association between CXCR2 and IL-22BP expression indicate a poor outcome for gastric adenocarcinoma progression

Yang

Han

et al. 2016

Oncology Letters

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“…Furthermore, it was shown that RA is able to induce the production of IL-22 binding protein by dendritic cells (28). This binding protein is a soluble receptor for IL-22, which has a higher affinity compared with the membrane-bound receptor and functions as a decoy receptor that controls the activity of IL-22 (29).…”

Section: Temporary Postnatal Inhibition Of Ra Signaling Affects Siltmentioning

confidence: 99%

Vitamin A Controls the Presence of RORγ+ Innate Lymphoid Cells and Lymphoid Tissue in the Small Intestine

Goverse

Labão-Almeida²,

Ferreira³

et al. 2016

The Journal of Immunology

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Changes in diet and microbiota have determining effects on the function of the mucosal immune system. For example, the active metabolite of vitamin A, retinoic acid (RA), has been described to maintain homeostasis in the intestine by its influence on both lymphocytes and myeloid cells. Additionally, innate lymphoid cells (ILCs), important producers of cytokines necessary for intestinal homeostasis, are also influenced by vitamin A in the small intestines. In this study, we show a reduction of both NCR− and NCR+ ILC3 subsets in the small intestine of mice raised on a vitamin A–deficient diet. Additionally, the percentages of IL-22–producing ILCs were reduced in the absence of dietary vitamin A. Conversely, mice receiving additional RA had a specific increase in the NCR− ILC3 subset, which contains the lymphoid tissue inducer cells. The dependence of lymphoid tissue inducer cells on vitamin A was furthermore illustrated by impaired development of enteric lymphoid tissues in vitamin A–deficient mice. These effects were a direct consequence of ILC-intrinsic RA signaling, because retinoic acid–related orphan receptor γt–Cre × RARα-DN mice had reduced numbers of NCR− and NCR+ ILC3 subsets within the small intestine. However, lymphoid tissue inducer cells were not affected in these mice nor was the formation of enteric lymphoid tissue, demonstrating that the onset of RA signaling might take place before retinoic acid–related orphan receptor γt is expressed on lymphoid tissue inducer cells. Taken together, our data show an important role for vitamin A in controlling innate lymphoid cells and, consequently, postnatal formed lymphoid tissues within the small intestines.

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“…To generate mucosal CD103 + Sirpα + (DP) resembling moDCs, RA, the even more potent RARalpha agonist AM580 or TGFbeta, can be added to the culture (Hartog et al 2013 ;Martin et al 2014 ). RA-induced moDCs express CD103 and can induce increased percentages of FoxP3 + in allogeneic CD4 + cells.…”

Section: Monocyte-derived Dcsmentioning

confidence: 99%

Dendritic Cells

Plantinga

Haar

Nierkens

2015

The Impact of Food Bioactives on Health

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Dendritic cells (DCs) are the sentinels of the immune system and play a critical role in stimulating immune responses against pathogens and maintaining immune homeostasis to harmless antigens. They can be found in all lymphoid and most non-lymphoid tissues, including mucosal surfaces, like the lung and the gut, where intricate networks of DCs are situated to sense potential harmful exposures. As such, DCs are among the fi rst cells to come into contact with food bioactives in the gastrointestinal tract and thus are instrumental in shaping the immune system's response to such exposures. Here we provide an overview of DC characteristics, with the emphasis on DCs in the mucosal immune system, and discuss in vitro/ex vivo DC culture settings that can be applied for in vitro testing of (food) compounds.

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Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid

Cited by 127 publications

References 53 publications

Association between CXCR2 and IL-22BP expression indicate a poor outcome for gastric adenocarcinoma progression

Association between CXCR2 and IL-22BP expression indicate a poor outcome for gastric adenocarcinoma progression

Vitamin A Controls the Presence of RORγ+ Innate Lymphoid Cells and Lymphoid Tissue in the Small Intestine

Dendritic Cells

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