Interleukin-21 Receptor Might be a Novel Therapeutic Target for the Treatment of Rheumatoid Arthritis

Seif, Farhad; Khoshmirsafa, Majid; Mousavi, Mohammad Javad; Beshkar, Pezhman; Rafeian-Kopaei, Mahmoud; Bagheri, Nader; Shirzad, Hedayatollah

doi:10.1016/j.jecm.2014.02.010

Cited by 11 publications

(6 citation statements)

References 42 publications

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“…Nosocomial infection is referred to as an infection that has occurred within 72 hours, 3 days of discharge, or a 30day period after the surgery (22). About 30% of these infections are caused by Gram-negative bacteria and these statistics reach to 70% in ICU-hospitalized patients (6,23). The incidence of nosocomial infections due to the MDR Gram-negative organisms, including Pseudomonas aeruginosa, A. bumanni (24), and positive germs such as methicillin-resistant Staphylococcus aureus (25), have increased dramatically in recent years.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and antibiotic resistance of Acinetobacter baumannii among patients in postcardiac surgery intensive care units of Rajaei Hospital, Tehran

Kamali¹,

Manshouri²,

Bagheri³

et al. 2020

mjiri

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is an aerobic, nonfermentative, Gram-negative microorganism, causing major nosocomial infections, especially in patients hospitalized in intensive care units (ICU). The prevalence of A. baumannii and its resistance to antibiotics may promote health conditions and save patients' lives. →What this article adds:The high prevalence and, on the other hand, the sensitivity of A. baumannii to Meropenem and Colistin are notable to treat patients in a more targeted manner and provide new disinfection approaches.

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Section: Discussionmentioning

confidence: 99%

Prevalence and antibiotic resistance of Acinetobacter baumannii among patients in postcardiac surgery intensive care units of Rajaei Hospital, Tehran

Kamali¹,

Manshouri²,

Bagheri³

et al. 2020

mjiri

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“…Experiments were assayed in duplicate for each sample. The mean threshold cycle values were normalized to beta actin (β-actin) expression levels, and the relative mRNA levels of target genes were calculated by 2 −ΔΔCt method [ 23 , 24 ].…”

Section: Methodsmentioning

confidence: 99%

Frequency of CD4+ and CD8+ T cells in Iranian chronic rhinosinusitis patients

Seif

Ghalehbaghi

Aazami

et al. 2018

Allergy Asthma Clin Immunol

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BackgroundChronic Rhinosinusitis (CRS) is a persistent inflammatory disease affecting paranasal sinuses. CRS is categorized into two distinct subgroups defined as CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). Although several immune cells are involved in the CRS pathogenesis, the role of T cells is not fully understood. The objective of the present study was to evaluate the frequency of CD4+ and CD8+ T cells and macrophages in the sinonasal mucosa of CRS patients, as well as to investigate the specific transcription factors for Th1, Th2, Th17, and Treg cells.MethodsIn this study, 15 healthy controls, 12 CRSsNP, and 23 CRSwNP patients participated. CD4+, CD8+, and CD68+ cells were investigated in the sinonasal tissues using immunohistochemistry. The expression of transcription factors related to Th subsets (T-bet, GATA3, Ror-γt, and FoxP3) was evaluated using real-time PCR. Furthermore, CRSwNP patients were defined as eosinophilic when eosinophils consisted of more than 10% of total inflammatory cells. The Kruskal–Wallis, Mann–Whitney, and Spearman tests were used in statistical analyses.ResultsThe median (range) age of the studied groups was: 32 (14–67) for CRSwNP, 28 (10–43) for CRSsNP, and 27 (17–44) for controls. The number of eosinophils in CRSwNP patients was higher than two other groups, whereas neutrophils were elevated in both CRSwNP and CRSsNP groups in comparison to controls. The frequency of CD4+ and CD8+ T cells, macrophages, and total inflammatory cells were significantly increased in CRSwNP and CRSsNP patients compared with controls. The mRNA expression of GATA3 was increased in CRSwNP patients while mRNA expression of Ror-γt was elevated in CRSsNP patients. No significant difference was observed in T-bet mRNA expression among three groups. Both CRSwNP and CRSsNP patients showed decreased FoxP3 mRNA expression in comparison to controls.ConclusionThe frequency of CD4+ and CD8+ T cells was elevated in CRS patients. In addition, we demonstrated Th2 dominance in CRSwNP patients and Th17 dominance in CRSsNP patients, implicating different mechanisms may underlie the disease. Better CRS classification and targeted therapeutic strategies may be achievable by determining the pattern of infiltrating inflammatory cells. Therefore, further experimental investigations on T cells are needed.

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“…Quantitative variables were compared by Mann-Whitney U test. 19 Comparison between qualitative variables was done by Chi-square test. The results were expressed as odds ratio with a 95% confidence interval IU/L before desensitization to less than 0.1 after the treatment was negative in other patients before the treatment (P > 0.9) (Table 3).…”

Section: Discussionmentioning

confidence: 99%

The Effectiveness of Oral Immunotherapy in Patients with Sesame Anaphylaxis using Omalizumab

et al. 2022

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in sesame allergy. 3 Although double-blind placebo oral food challenge (OFC) is the gold standard test for sesame allergy diagnosis, 1 on the basis of our previous study, other diagnostic methods such as prick test (SPT), skin prick to prick (SPP), specific IgE (sIgE), and finally, SPP may be suggested for diagnosis of those patients who cannot perform OFC. 4 Owing to the lack of a confirmed protocol and the increased sesame consumption in recent years, the true rate of sesame allergy may be higher in Iran. 5,6 Clinical manifestations range from S esame allergy is the most common allergy to seeds and its prevalence is increasing worldwide. 1 It has been recently estimated that sesame allergy affects 0.23% of US children and adults. A smaller, population-based study performed more than a decade ago introduced sesame as a food allergen, influencing about 0.1% of US children and adults. It shows the prevalence of sesame allergy is increasing. 2 Anaphylaxis is a life-threatening systemic, rapid onset reaction that its management is a clinical emergency, especially

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Interleukin-21 Receptor Might be a Novel Therapeutic Target for the Treatment of Rheumatoid Arthritis

Cited by 11 publications

References 42 publications

Prevalence and antibiotic resistance of Acinetobacter baumannii among patients in postcardiac surgery intensive care units of Rajaei Hospital, Tehran

Prevalence and antibiotic resistance of Acinetobacter baumannii among patients in postcardiac surgery intensive care units of Rajaei Hospital, Tehran

Frequency of CD4+ and CD8+ T cells in Iranian chronic rhinosinusitis patients

The Effectiveness of Oral Immunotherapy in Patients with Sesame Anaphylaxis using Omalizumab

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