Interleukin-20 promotes angiogenesis in a direct and indirect manner

IL-20: biological functions and clinical implications

“…Tissue distribution analysis demonstrated that both human and mouse shortforms are tissue-specific. The short-form variant of human IL-20 was found in lung tissue [20], while the short-form variant of mouse IL-20 was expressed in brain tissue only.…”

“…Several observations showed that IL-20 signaled through different pathways in different cell types: STAT3 in keratinocyte cell lines (HaCaT) [7]; ERK1/2 in RA synovial fibroblasts [23]; p38 kinase, JNK, and ERK1/2 in endothelial cells (HUVECs) [20]. All three subunits of IL-20 receptors are co-expressed in these cells, but they transmit different signals to IL-20.…”

Mouse interleukin-20 receptor 1a targets renal epithelial cells and is associated with renal calcium deposition

“…5 Within this subfamily, IL-19, IL-20 and IL-24 share receptor complexes; 6 all of them are capable of signaling through IL-20R1/IL-20R2 and IL-20 and IL-24 can also use IL-22R/ IL-20R2. 6 Because a growing number of studies have revealed the association of IL-19, 7-9 IL-20 8,[10][11][12][13][14][15][16] and IL-24 [17][18][19][20][21][22] with diseases, the identification of soluble proteins derived from the genes of the functional receptors may provide more insights into the biomolecular mechanisms of their functions.…”

Anti–IL-20 Monoclonal Antibody Alleviates Inflammation in Oral Cancer and Suppresses Tumor Growth

“…7E has shown specificity and neutralization activity in vitro and in vivo (24,28,33). Therefore, we analyzed whether 7E reduced tumor growth in vivo.…”

“…We previously showed (26,28) that IL-20 not only promoted angiogenesis but also increased tumor vascularization. Moreover, IL-20 is regulated by hypoxia and contributes to brain injury in an ischemic stroke model, which indicates that IL-20 is a promoting factor in the inflammation-associated disease (29).…”