Interleukin-2 modulates the responsiveness to angiotensin II in cultured vascular smooth muscle cells

Nabata, T; Fukuo, Keisuke; Morimoto, Shigeto; Kitano, Shiro; Momose, N; Hirotani, Atsushi; Nakahashi, Takeshi; Nishibe, Akira; Hata, Shinsuke; Niinobu, Takahiro; Suhara, Toshiaki; Shimizu, Mitsuru; Ohkuma, H; Sakurai, Shoroku; Nishimaki, Hiroyuki; Ogihara, Toshio

doi:10.1016/s0021-9150(97)00107-x

Cited by 14 publications

(11 citation statements)

References 45 publications

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“…A recent study by Bae et al indicated that IL-2 promotes angiogenesis, and demonstrated that endothelial cells express IL-2Rα and β 23 . IL-2 has also been shown to stimulate GAG synthesis in vascular smooth muscle cells and enhance their responsiveness to angiotensin II 46 . Our histologic examination of aortas from IL-2 deficient mice suggests that IL-2 plays a role in maintaining vascular smooth muscle cells.…”

Section: Discussionmentioning

confidence: 99%

Interleukin‐2 is present in human blood vessels and released in biologically active form by heparanase

et al. 2011

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Interleukin-2 is a multifaceted cytokine with both immunostimulatory and immunosuppressive properties. Our laboratory recently demonstrated that the availability of IL-2 is regulated, in part, by association with perlecan, a heparan sulfate proteoglycan. Given the abundance of perlecan in blood vessels, we asked whether IL-2 is present in vessel walls. Our results indicate that IL-2 is associated with endothelial and smooth muscle cells within the human arterial wall. This IL-2 is released by heparanase, and promotes the proliferation of an IL-2 dependent cell line. Given the presence of IL-2 in human arteries, we asked whether the large vessels of IL-2 deficient mice were normal. The aortas of IL-2 deficient mice exhibited a loss of smooth muscle cells, suggesting that IL-2 may contribute to their survival. In their entirety, these results suggest a here-to-fore unrecognized role of IL-2 in vascular biology, and have significant implications for both the immune and cardiovascular systems.

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Section: Discussionmentioning

confidence: 99%

Interleukin‐2 is present in human blood vessels and released in biologically active form by heparanase

et al. 2011

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“…Nabata et al [40] suggested that IL-2 is related to the pathogenesis of atherosclerosis and vascular disease by modulating the response to angiotensin II. Procyanidins, abundant in cranberry and chocolate, inhibit IL-2 expression and modulate IL-2 production in cells [41].…”

Section: Discussionmentioning

confidence: 99%

Effects of freeze-dried cranberry powder on serum lipids and inflammatory markers in lipopolysaccharide treated rats fed an atherogenic diet

et al. 2011

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This study investigated the effects of freeze-dried cranberry powder on anti-inflammation and lipid profiles of lipopolysaccharide (LPS)-treated rats fed an atherogenic diet for 6 weeks. Forty Sprague-Dawley male rats (6-weeks-old) were equally divided into the following five groups: 1) normal diet group + saline (NC); 2) atherogenic diet + saline (HFC); 3) atherogenic diet + LPS (HL); 4) atherogenic diet with 5% cranberry power + LPS (C5); 5) atherogenic diet with 10% cranberry power + LPS (C10). LPS (0.5 mg/kg) was injected into the abdominal cavities of rats 18 hours prior to sacrifice. At the end of the experimental period, we measured serum lipid profiles as well as levels of serum C-reactive protein (CRP), nitric oxide (NO), and pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, and IL-10 as an anti-inflammatory cytokine. The mean serum high density lipoprotein (HDL)-cholesterol level in C5 rats was significantly higher than that in NC and HL rats (P < 0.05). The mean serum levels of CRP and IL-1β were significantly lower (P < 0.05) in the cranberry powder groups compared to those in HL rats. Additionally, mean serum IL-6 levels tended to be lower in the cranberry groups than that in the HL group, whereas serum IL-10 and NO showed 29% and 88% higher mean values in the C5 group and 49% and 24% higher in the C10 group than those in the HL group, respectively. These results suggest that freeze-dried cranberry powder may have beneficial effects on cardiovascular diseases by modifying serum lipids and the early inflammatory response.

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“…(52) Proteoglycan synthesis is upregulated by TGFb, EGF, IGF-1 and PDGF (53,54, reviewed by 55). Glycosaminoglycan synthesis can be enhanced by IL-2, (56) TGFb1 (54,57,58) and PDGF. (59) In addition to cytokines altering matrix composition, the composition of the matrix can alter the response to cytokines.…”

Section: Effects On Apoptosis Of Smooth Muscle Cellsmentioning

confidence: 99%

“…(71) Neutrophils produce neutrophil elastase (matrix metalloproteinase-8), which has been implicated in both atheroma formation (55) and airway remodeling in asthma. (56) Eosinophilia in asthmatic airways is another condition where smooth-muscle-derived mediators, such as eotaxin and GM-CSF, may contribute to tissue pathology. GM-CSF is a peptide growth factor recovered from bronchioalveolar lavage fluid of asthmatics (72,73) that increases eosinophil proliferation and enhances survival of eosinophils and neutrophils.…”

Section: Review Articlesmentioning

confidence: 99%

Synthesis of immune modulators by smooth muscles

et al. 2004

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The primary function of smooth muscle cells is to contract and alter the stiffness or diameter of hollow organs such as blood vessels, the airways and the gastrointestinal and urogenital tracts. In addition to purely structural functions, smooth muscle cells may play important metabolic roles, particularly in various inflammatory responses. In cell culture, these cells have been shown to be metabolically dynamic, synthesizing and secreting extracellular matrix proteins, glycosaminoglycans and a wide variety of cell-cell signaling proteins, such as interleukins, chemokines and peptide growth factors. Secreted cell signaling proteins participate in the inflammatory response of smooth muscle-containing organs, and some can also stimulate smooth muscle migration, proliferation and contraction. The cellular signaling pathways controlling synthesis of these signaling proteins are similar to those used by cells mediating innate immunity and may contribute to pathogenesis of diverse diseases including atherosclerosis, asthma, inflammatory bowel diseases and preterm labor. Appreciating the role of smooth muscle cells in these diseases may lead to better understanding of the beneficial effects of anti-inflammatory drugs as well as identification of new targets for anti-inflammatory therapy.

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Interleukin-2 modulates the responsiveness to angiotensin II in cultured vascular smooth muscle cells

Cited by 14 publications

References 45 publications

Interleukin‐2 is present in human blood vessels and released in biologically active form by heparanase

Interleukin‐2 is present in human blood vessels and released in biologically active form by heparanase

Effects of freeze-dried cranberry powder on serum lipids and inflammatory markers in lipopolysaccharide treated rats fed an atherogenic diet

Synthesis of immune modulators by smooth muscles

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