Interleukin-2 levels are associated with carotid artery intima-media thickness

Elkind, Mitchell S.V.; Rundek, Tatjana; Sciacca, Robert R.; Ramas, Romel; Chen, Hong Jun; Boden‐Albala, Bernadette; Rabbani, Le Roy E.; Sacco, Ralph L.

doi:10.1016/j.atherosclerosis.2004.11.015

Cited by 48 publications

(40 citation statements)

References 32 publications

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“…On the basis of a systematic review and meta-analysis, it was concluded that carotid IMT is a distinct predictor of future vascular events, although the relative risk for prediction is slightly higher for stroke than for myocardial infarction. 14) Furthermore, other cardiovascular disease risk factors such as diabetes, 15) inflammatory diseases, 16,17) and sleep apnea have been associated with thicker carotid IMT. 18) However, cardiovascular events are not determined only by increased carotid IMT, as 75% of thrombi in the carotid are caused by rupture, and 30% to 35% of coronary thrombi are caused by erosion.…”

Section: Discussionmentioning

confidence: 99%

Cholesterol and Triglyceride Concentrations in Lipoproteins as Related to Carotid Intima-Media Thickness

Takahashi¹,

Taguchi²,

Suzuki³

et al. 2012

Int. Heart J.

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SummarySince distinct cholesterol and triglyceride concentrations in major lipoproteins and their subclasses may be related to atherosclerosis, we investigated the relationship of cholesterol and triglyceride concentrations in lipoprotein subclasses and the severity of carotid intima-media thickness (IMT), a surrogate marker of subclinical atherosclerosis. We studied 116 apparently healthy Japanese men (53 ± 9 years) without a history of cardiovascular diseases who were not taking any medication. Carotid IMT was measured by means of high-resolution vascular ultrasound. Plasma cholesterol and triglyceride concentrations in major lipoproteins and their subclasses were determined by HPLC with gel permeation columns. By univariate analyses, carotid IMT was the most closely related to age (r = 0.528, P < 0.001), followed by smoking habit expressed as pack-year cigarette consumption (r = 0.409, P < 0.001). In addition to total cholesterol and LDL cholesterol, carotid IMT was significantly associated with cholesterol and triglyceride concentrations in several LDL and VLDL subclasses. Stepwise multiple linear regression analysis revealed that age (β = 0.436, P < 0.001), smoking (pack-years) (β = 0.225, P = 0.007), and large LDL cholesterol (β = 0.175, P = 0.023) were independent predictors of determining carotid IMT (adjusted R 2 = 0.347, P < 0.001). These results indicate that large LDL cholesterol is an important, independent determinant of carotid IMT in healthy men. (Int Heart J 2012; 53: 29-34) Key words: Intima-media thickness, Lipoprotein, Large low-density lipoprotein cholesterol, High-performance liquid chromatography, Carotid artery T he plasma lipid profile is the most important indicator of risk for cardiovascular disease and stroke. Several components have been proposed as atherogenic lipids and lipoproteins, including low-density lipoprotein (LDL) cholesterol, apolipoprotein B, non-high-density lipoprotein (HDL) cholesterol, triglycerides, and small dense LDL.1,2) Low HDL cholesterol concentrations have gained notice for potentially increasing risk and promoting the development of atherosclerosis. Among plasma lipids, LDL still accounts for the bulk of clinical attention for the prevention of cardiovascular diseases. 3)However, lipoproteins are a heterogeneous group of particles that differ in terms of their physicochemical properties and biological behaviors. Increasingly, attempts have been made to improve evaluation by considering particular subfractions of plasma lipids, in particular LDL and HDL subclasses of atherogenic lipids and lipoproteins. 4) Recently, high-performance liquid chromatography (HPLC) with a gel permeation column has been established as an alternative method for classifying and quantifying lipoproteins on the basis of differences in particle size. 5,6) Intima-media thickness (IMT) in the carotid arteries, measured with high-resolution ultrasonography, is currently the standard clinical marker and a quantitative measure of atherosclerosis; a graded, predictive relationship to over...

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Section: Discussionmentioning

confidence: 99%

Cholesterol and Triglyceride Concentrations in Lipoproteins as Related to Carotid Intima-Media Thickness

Takahashi¹,

Taguchi²,

Suzuki³

et al. 2012

Int. Heart J.

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“…Processos inflamatórios crônicos relacionados à deposição visceral de gordura estimulam uma ampla ativação do sistema imune que, por sua vez, está envolvida na patogênese da resistência à insulina, do diabetes mellitus do tipo 2, das dislipidemias e da aterosclerose 17,18,19 .…”

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Prevalência e características associadas à síndrome metabólica em nipo-brasileiros com e sem doença periodontal

et al. 2007

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Verificou-se, num estudo transversal, a relação entre as doenças periodontais e a síndrome metabólica. Foram analisados dados de 1.315 nipo-brasileiros com idade entre 30 e 92 anos. Os indivíduos foram submetidos a exames físicos, odontológicos e laboratoriais. Os dados foram descritos através de médias e porcentagens e a associação entre as variáveis foi verificada por meio de regressão logística. Do total de sujeitos examinados, 215 (16,4%) apresentaram higidez periodontal, 484 (36,8%) edentulismo total, 513 (39%) gengivites, 85 (6,5%) periodontite inicial ou moderada e 18 (1,4%) periodontite avançada. A prevalência de síndrome metabólica entre os nipo-brasileiros foi 54,3%, e apesar de esta ter sido maior entre os que apresentaram periodontites quando comparados aos sem nenhum comprometimento da saúde bucal (51,5% vs. 48,8%) essa associação não foi estatisticamente significante. Neste estudo os indivíduos com síndrome metabólica se caracterizaram por pior perfil antropométrico e metabólico.

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“…M ost notable research with neurovascular ultrasound in 2005 focused on treatment amplification, [1][2][3] identification of high-risk patients with intracranial stenoses, 4 increased carotid intima-media thickness, 5,6 monitoring repairs of ascending aorta, 7 carotid stenting, 8,9 patient selection and outcomes with percutaneous patent foramen ovale closure, 10 and acute stroke treatment. [11][12][13][14][15] Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) was a randomized, double-blind study in subjects with recently symptomatic Ն50% carotid stenosis.…”

mentioning

confidence: 99%

“…Reports demonstrate the ability of IMT to discriminate individuals at low and high 1-year event risk, 5 and link increased IMT to inflammation as a potential new target in stroke prevention. 6 TCD provides real-time monitor to detect hypoperfusion, embolism and thrombosis during surgical and stenting procedures. Most encouraging results were obtained in a cohort of patients undergoing urgent repairs of ascending aortic aneurysms.…”

mentioning

confidence: 99%