Interleukin‐2 gene polymorphism inTurkish patients withBehçet's disease and its association with ocular involvement

Abstract

Behçet's disease (BD) is a chronic immune-mediated systemic disease, characterized by oral and genital lesions and ocular inflammation. Several cytokine genes may play crucial roles in host susceptibility to BD, because the cytokine production capacity varies among individuals and depends on the cytokine gene polymorphisms. The association of the interleukin (IL)-2 gene polymorphisms with the susceptibility to BD was investigated in this study. DNA samples were obtained from a Turkish population of 97 patients with BD and 76 healthy control subjects. Polymorphisms of IL-2 gene at position -330 and +166 were determined using the polymerase chain reaction with sequence-specific primers. In the patients with BD, there was a significantly increased frequency of IL-2 -330 GT genotype. Interestingly, we demonstrated that the frequencies of IL-2 -330 GT and IL-2 + 166 GG genotypes were increased in BD patients with ocular involvement, whilst IL-2 -330 TT genotype was significantly decreased. Also, analysis of allele frequency demonstrated that the presence of G allele at position +166 of IL-2 seems to be a risk factor for ocular involvement. These results reveal that IL-2 -330 GT genotype may be a susceptibility factor for BD, whereas IL-2 -330 TT genotype seems to display a protective association with BD. Additionally, IL-2 gene polymorphisms might be associated with ocular involvement in BD.

The impact of the IL-1β, IL-1Ra, IL-2, IL-6 and IL-10 gene polymorphisms on the development of Behcet's disease and their association with the phenotype

“…14 A trial by Kotter et al detected that the serum IL1Ra levels increased following treatment with an anti-inflammatory agent in BD patients with ocular involvement. 17 While we failed to observe a correlation between the IL-2 gene polymorphism and the ocular involvement, the results were found to be statistically significant when the IL-1␤ gene polymorphism was assessed for ocular involvement.…”

Association of Disease Activity with Serum and Tear IL-2 Levels in Behçet Disease

“…29 A recent study reported that IL-2 gene polymorphisms might be associated with ocular involvement in BD. 30 Recently there have been conflicting data regarding the role of IL-2 in BD. Akkurt et al 10 reported similar serum levels of IL-2 in patients with BD and the control group.…”

IL-1RN VNTR, IL-2(-330), and IL-4 VNTR gene polymorphisms in patients with chronic rhinosinusitis with sinonasal polyposis

“…In this study, we also researched the IL-2(-330) gene polymorphism of patients with CRSwNP. This gene polymorphism is linked to many inflammatory and neoplastic diseases such as basal cell carcinoma, Graves' disease (IL-2 -330T/G), hepatocellular carcinoma; multiple sclerosis IL-2 (-330 T/T), Behçet's disease where the IL-2 (-330 GT) genotype shows susceptibility and the IL-2(-330 T/T) genotype shows a preventive impact, nasopharyngeal carcinoma IL-2 (-330 T/G), neuroendocrine tumors, and asthma IL-2 (-330) and IL-2 (+166) [26][27][28][29][30][31][32][33]. The gene and haplotype profiles of patients with asthma and chronic obstructive airway disease (COPD) have been mentioned in a few studies.…”