Interleukin-2 and Interleukin-6 Gene Promoter Polymorphisms, and Early Failure of Dental Implants

Campos, Maria Isabela Guimarães; Santos, Maria Cristina Leme Godoy dos; Trevilatto, Paula Cristina; Scarel‐Caminaga, Raquel Mantuaneli; Bezerra, Fábio; Line, Sérgio Roberto Peres

doi:10.1097/01.id.0000188470.54417.98

Cited by 31 publications

(65 citation statements)

References 45 publications

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“…The correlation between biochemical markers of inflammation and clinical parameter of health and disease around the implant are the focus of recent studies (3). In the presence of periodontal pathogens, the immune response may trigger a higher or lower degree of cytokine production or interfere with its physiology (14). In CP, the pro-inflammatory immune response is highly related to bone loss.…”

Section: Discussionmentioning

confidence: 99%

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History of Chronic Periodontitis Is a High Risk Indicator for Peri-Implant Disease

et al. 2013

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The success rates in implant dentistry vary significantly among patients presenting previous history of periodontitis. The aim of this study was to evaluate if patients with history of chronic periodontitis (CP) are more susceptible to peri-implant disease (PID) than those without history of CP. Two hundred and fifteen individuals, under periodontal maintenance, presenting 754 osseointegrated implants, were selected for this study. The patients were divided into two groups according to the peri-implant status: Control group (patients without PID; n=129) and PID group (patients with PID; n=86). All peri-implant regions were clinically evaluated, including analyses of mucosa inflammation, edema and implant mobility. Periapical radiography assessed the presence of peri-implant bone loss. According to the clinical/radiographic characteristics, patients in Control and PID groups were diagnosed as having CP or not. Nominal variables were evaluated by the chi-square test. The distribution of numeric variables was analyzed by Shapiro-Wilk test. Student's t-test and Mann-Whitney test were used to analyze significant differences for parametric and non-parametric data. A p-value <0.05 was considered significant. There was a highly significant correlation between CP history and PID (p<0.0001). Patients with CP had 4 times more chance of developing PID than patients with healthy periodontal tissues. Also, CP patients showed higher bleeding on probing (p=0.002) and bone loss around implant (p=0.004) when compared with patients without CP. In conclusion, history of CP is a high risk factor for the development of PID, irrespective of gender or region of implant placement.

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Section: Discussionmentioning

confidence: 99%

“…Moreover, the host response is influenced by several possible risk factors including genetic factors. Previous studies indicated that chronic periodontitis (CP) may have a genetic background (12,13), as well as PID (14,15).…”

Section: Introductionmentioning

confidence: 99%

History of Chronic Periodontitis Is a High Risk Indicator for Peri-Implant Disease

et al. 2013

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“…Salcetti et al (7) likewise recorded no differences in the levels of IL-6 on comparing patients with failed implants versus those with sta�le dental implants. Campos et al (5), in 74 patients, analyzed the relationship �etween the polymorphic gene encoding for IL-6 and early dental implant loss. They concluded that such polymorphism does not constitute a genetic risk factor for early implant loss.…”

Section: Influence Of Interleukins 6 8 10 and 12 Upon Periimplant Imentioning

confidence: 99%

“…The increase in cytokine concentration in the crevicular fluid of dental implants may lead to a lack of osteointegration, �one loss or implant failure (5)(6)(7). Bone is a dynamic tissue continuously su�ject to remodeling through rea�sorption and formation, these processes �eing controlled �y the local production of cytokines, among other factors (4).…”

Section: Influence Of Interleukins 6 8 10 and 12 Upon Periimplant Imentioning

confidence: 99%

Interleukins IL-6, IL-8, IL-10, IL-12 and periimplant disease. An update

et al. 2011

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“…However, genotype 2/2 of IL1RN polymorphism was significantly more frequent in patients who presented multiple losses. Some other functional polymorphisms in inflammatory candidate genes were also analyzed: IL2 (Campos et al, 2005a), IL6 (Campos et al, 2005a;Melo et al, 2011), and TNFA (Campos et al, 2004;Cury et al, 2007;Cury et al, 2009) (Table 1). Also, genes involved in the regulation of ECM such as TGFB1 (Santos et al, 2004a), MMP1 (Leite et al, 2008;Santos et al, 2004b) and MMP9 (Santos et al, 2004b) have been investigated (Table 1).…”

Section: Genetic Polymorphisms and Dental Implant Failurementioning

confidence: 99%

The Current Knowledge of Genetic Susceptibility Influencing Dental Implant Outcomes

Alvim-Pereira¹,

Alvim-Pereira²,

Trevilatto³

2011

Implant Dentistry - The Most Promising Discipline of Dentistry

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Interleukin-2 and Interleukin-6 Gene Promoter Polymorphisms, and Early Failure of Dental Implants

Cited by 31 publications

References 45 publications

History of Chronic Periodontitis Is a High Risk Indicator for Peri-Implant Disease

History of Chronic Periodontitis Is a High Risk Indicator for Peri-Implant Disease

Interleukins IL-6, IL-8, IL-10, IL-12 and periimplant disease. An update

The Current Knowledge of Genetic Susceptibility Influencing Dental Implant Outcomes

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