Interleukin-2 and 13-cis retinoic acid in the treatment of minimal residual disease: A phase II study

Recchia, F.; Filippis, Sandro De; Rosselli, Michele; Saggio, Gaetano; Fumagalli, Luca; Rea, Silvio

doi:10.3892/ijo.20.6.1275

Cited by 6 publications

(5 citation statements)

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“…As described above, retinoids have already been used with some success for the treatment of APL (Huang et al, 1988). Natural and synthetic retinoids are also undergoing clinical investigation in combination therapies for the treatment of solid tumors (Recchia et al, 2001, 2002, 2005; Goldberg et al, 2002; Shin et al, 2002; Singletary et al, 2002; Boorjian et al, 2007). However, resistance to the growth inhibitory effects of retinoids is a feature common to many cancer cells (van der Burg et al, 1993; Petty et al, 2005).…”

Section: Retinoids In Cancer Chemoprevention and Cancer Therapymentioning

confidence: 99%

Diverse actions of retinoid receptors in cancer prevention and treatment

2007

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Section: Retinoids In Cancer Chemoprevention and Cancer Therapymentioning

confidence: 99%

Diverse actions of retinoid receptors in cancer prevention and treatment

2007

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“…Carotenoids perform anti-tumorigenic effects by several other mechanisms, including enhanced gap junction communication, stimulation of the antioxidant response element transcription system, inhibition of IGF-driven cell proliferation, or scavenging of ROS [ 70 , 173 , 174 , 175 ]. They also stimulate the immune system by increasing the levels of lymphocytes and natural killer cells [ 176 ].…”

Section: Vitamin a Actions Through Nuclear Receptors And The Roles Of Carotenoids In Regulation Of Cell Signaling In Breast Cancer—reviewmentioning

confidence: 99%

An Updated Comprehensive Review on Vitamin A and Carotenoids in Breast Cancer: Mechanisms, Genetics, Assessment, Current Evidence, and Future Clinical Implications

2021

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Vitamin A and carotenoids are fat-soluble micronutrients that play important role as powerful antioxidants modulating oxidative stress and cancer development. Breast cancer is the most common malignancy in women. As the risk of breast cancer is dependent on various lifestyle factors such as dietary modifications, there is increasing interest surrounding the anti-cancerous properties of vitamin A and carotenoids. Despite the suggested protective roles of vitamin A and carotenoids in breast cancer development, their clinical application for the prevention and treatment of breast cancer is limited. In this narrative review, we discuss the roles of vitamin A and carotenoids along with the evaluation method of vitamin A status. We also exhibit the association of genetic variations involved in metabolism of vitamin A and carotenoids with cancers and other diseases. We demonstrate the epidemiological evidence for the relationship of vitamin A and carotenoids with breast cancer risk, their effects on cancer mechanism, and the recent updates in clinical practice of vitamin A or carotenoids as a potential therapeutic agent against breast cancer. This review provides insight into the preventive and therapeutic roles of vitamin A and carotenoids in breast cancer development and progression.

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“…A phase II study suggests the beneficial use of a combination of IL-2 and isotretinoin in minimal residual disease in metastatic solid tumors in complete remission after chemotherapy. 151 Among the non-dermatologic indication of isotretinoin is neuroblastoma, for which it is used as adjuvant treatment. 152 …”

Section: Repurposing Of Dermatologic Medications To Treat Covid-19mentioning

confidence: 99%

Drug repurposing of dermatologic medications to treat coronavirus disease 2019: Science or fiction?

Mateeva

Drenovska

2021

Clinics in Dermatology

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No pharmaceutical products have been demonstrated to be safe and effective to specifically treat coronavirus disease 2019 (COVID-19); therefore, the therapy administered to infected patients remains symptomatic and empiric. Alongside the development of new, often high-cost drugs, a different tactic is being applied in parallel, investigating long-established, inexpensive medications originally designed for a variety of diseases to study their potential in treating COVID-19. The skin is the largest organ of the human body. With more than 3,000 skin conditions identified, the specialty of dermatology offers a rich armamentarium of systemic therapeutic agents aimed to treat the various chronic immunologically mediated, metabolic, infectious, occupational, inherited, or paraneoplastic dermatoses. Dermatologists have extensive experience with many drugs that have demonstrated promising in vitro antiviral action (directly targeting the viral replication). Many of these drugs have been used as nonspecific immunosuppressive strategies, such as glucocorticoids, synthetic antimalarials, colchicine, or other immunomodulators, and a number of targeted therapeutics have been directed at controlling hyperinflammatory processes similar to the “cytokine storm” associated with COVID-19 infection. We discuss several dermatologic drugs that have already been used or may have a promising role in the treatment of COVID-19.

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Interleukin-2 and 13-cis retinoic acid in the treatment of minimal residual disease: A phase II study

Cited by 6 publications

References 0 publications

Diverse actions of retinoid receptors in cancer prevention and treatment

Diverse actions of retinoid receptors in cancer prevention and treatment

An Updated Comprehensive Review on Vitamin A and Carotenoids in Breast Cancer: Mechanisms, Genetics, Assessment, Current Evidence, and Future Clinical Implications

Drug repurposing of dermatologic medications to treat coronavirus disease 2019: Science or fiction?

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