Interleukin-1β, Interleukin1-Ra, Interleukin-10, and tumor necrosis factor-α polymorphisms in Tunisian patients with rheumatoid arthritis

Single Nucleotide Polymorphism of IL1B Gene (rs16944) in a Sample of Rheumatoid Arthritis Iraqi Patients

“…A negative association between IL1B -511 T allele and RA was reported in Caucasian patients, while in Asian RA patients, no such association was observed [11]. In Tunisian RA patients, IL1B -511 SNP (T/C) was suggested to be associated with susceptibility and severity of disease [12]. More recently, the SNP IL1B -511 showed a significant association with chronic periodontitis and RA in Mexican patients [15].…”

“…However, the TT+TC genotype of IL1B -3953 SNP (C/T) showed a positive association between Caucasian and Asian RA patients [11]. In Tunisian RA patients, IL1B -511 SNP (C/T) was suggested to be associated with susceptibility and severity of disease [12].…”

Statistical analysis of the relationship between IL-10 gene promoter polymorphisms and the development of coronary artery disease

“…Polymorphisms in the IL-10 can alter the structure and quantity of this gene, and consequently influencing the expression and function of the product. Previous studies have demonstrated that IL-10 genetic polymorphisms could affect the risk of many autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, Graves' disease and peptic ulcer (Sugimoto et al, 2007;Liu et al, 2011;da Silva et al, 2004;Lagha et al, 2015). Sugimoto et al (2007) carried out a study in a Japanese population, and reported that IL-10 -1082/-819/-592 haplotypes were correlated with an elevated risk for gastric cancer.…”

Association between -1082G/A, -819C/T, and -592C/A genetic polymorphisms in IL-10 and risk of type 2 diabetes mellitus in a Chinese population

“…IL-10 polymorphisms may induce genetic and molecular aberrations, which could result in the development of several types of autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis, ulcerative colitis, and Crohn's disease, in addition to acute pancreatitis (Amre et al, 2009;Marrakchi et al, 2009;Paradowska-Gorycka et al, 2010;da Silva et al, 2014;Lagha et al, 2015;Li et al, 2015;Talaat et al, 2015). Talaat et al (2015) reported an association between the clinical features and risk of systemic lupus erythematosus and IL-10 -1082G/A polymorphisms in an Egyptian population.…”

“…da Silva et al (2014) discovered that the IL-10 -1082G/A polymorphism contributed to susceptibility to systemic lupus erythematosus in a Brazilian population. Lagha et al (2015) reported an association between the IL-10 -1082G/A polymorphisms and susceptibility to rheumatoid arthritis. Paradowska-Gorycka et al (2010) conducted a study involving 244 patients with rheumatoid arthritis and 106 healthy controls, and reported that the IL-10 -592C/A and -1082G/ A polymorphisms may play an important role in the susceptibility to rheumatoid arthritis.…”