Interleukin-1β induces pericyte apoptosis via the NF-κB pathway in diabetic retinopathy

Yun, Jang-Hyuk

doi:10.1016/j.bbrc.2021.01.108

Cited by 37 publications

(38 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, another potential limitation is the absence of an association between secondary complications, such as diabetic retinopathy, and the IL-1β levels. It was demonstrated that IL-1β increased in the diabetic mouse retina and IL-1β induced pericyte apoptosis via NF-κB activation under high glucose conditions, thereby increasing endothelial permeability in diabetic retinopathy [ 45 ]. However, we could not undertake a meta-analytical approach on the diabetic secondary complications due to the low number of articles with inclusion criteria established.…”

Section: Discussionmentioning

confidence: 99%

IL-1β Implications in Type 1 Diabetes Mellitus Progression: Systematic Review and Meta-Analysis

Cano-Cano

Gómez-Jaramillo

Ramos‐García

et al. 2022

JCM

View full text Add to dashboard Cite

During Type 1 Diabetes Mellitus (T1DM) progression, there is chronic and low-grade inflammation that could be related to the evolution of the disease. We carried out a systematic review and meta-analysis to evaluate whether peripheral levels of pro-inflammatory markers such as interleukin-1 beta (IL-1β) is significantly different among patients with or without T1DM, in gender, management of the T1DM, detection in several biological fluids, study design, age range, and glycated hemoglobin. We searched PubMed, Embase, Web of Science, and Scopus databases, and 26 relevant studies (2186 with T1DM, 2047 controls) were included. We evaluated the studies’ quality using the Newcastle–Ottawa scale. Meta-analyses were conducted, and heterogeneity and publication bias were examined. Compared with controls, IL-1β determined by immunoassays (pooled standardized mean difference (SMD): 2.45, 95% CI = 1.73 to 3.17; p < 0.001) was significantly elevated in T1DM. The compared IL-1β levels in patients <18 years (SMD = 2.81, 95% CI = 1.88–3.74) was significantly elevated. The hemoglobin-glycated (Hbg) levels in patients <18 years were compared (Hbg > 7: SMD = 5.43, 95% CI = 3.31–7.56; p = 0.001). Compared with the study design, IL-1β evaluated by ELISA (pooled SMD = 3.29, 95% CI = 2.27 to 4.30, p < 0.001) was significantly elevated in T1DM patients. IL-1β remained significantly higher in patients with a worse management of T1DM and in the early stage of T1DM. IL-1β levels determine the inflammatory environment during T1DM.

show abstract

Section: Discussionmentioning

confidence: 99%

IL-1β Implications in Type 1 Diabetes Mellitus Progression: Systematic Review and Meta-Analysis

Cano-Cano

Gómez-Jaramillo

Ramos‐García

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

“…This could imply that the phagocytic amoeboid morphotype is more actively involved in later stages of clinical DR, however, further validation and a greater sample size is necessary. In terms of microglia-associated factors, there have been reports showing early changes in expression of CD11b, C1r, IL-1β, IL-6, and TNF-α, in the context of DR-associated pathologies e.g., vascular permeability, neuronal function, and neovascularisation ( Rangasamy et al, 2014 ; Karlstetter et al, 2015 ; Madeira et al, 2015 ; Kinuthia et al, 2020 ; Li et al, 2021 ; Xie et al, 2021 ; Yun, 2021 ). Such changes in expression have also been correlated with amoeboid and activated microglia, microglial ‘activation’, apoptosis, and phagocytosis ( Rangasamy et al, 2014 ; Karlstetter et al, 2015 ; Madeira et al, 2015 ; Kinuthia et al, 2020 ; Li et al, 2021 ; Xie et al, 2021 ; Yun, 2021 ).…”

Section: Retinal Microglia In Degenerative Eye Diseasesmentioning

confidence: 99%

Microglia: Key Players in Retinal Ageing and Neurodegeneration

Guo

Choi

Bikkannavar

et al. 2022

Front. Cell. Neurosci.

View full text Add to dashboard Cite

Microglia are the resident immune cells of the central nervous system (CNS) and play a key role in maintaining the normal function of the retina and brain. During early development, microglia migrate into the retina, transform into a highly ramified phenotype, and scan their environment constantly. Microglia can be activated by any homeostatic disturbance that may endanger neurons and threaten tissue integrity. Once activated, the young microglia exhibit a high diversity in their phenotypes as well as their functions, which relate to either beneficial or harmful consequences. Microglial activation is associated with the release of cytokines, chemokines, and growth factors that can determine pathological outcomes. As the professional phagocytes in the retina, microglia are responsible for the clearance of pathogens, dead cells, and protein aggregates. However, their phenotypic diversity and phagocytic capacity is compromised with ageing. This may result in the accumulation of protein aggregates and myelin debris leading to retinal neuroinflammation and neurodegeneration. In this review, we describe microglial phenotypes and functions in the context of the young and ageing retina, and the mechanisms underlying changes in ageing. Additionally, we review microglia-mediated retinal neuroinflammation and discuss the mechanisms of microglial involvement in retinal neurodegenerative diseases.

show abstract

“…IL-1β is a pivotal inflammatory cytokine because it is able to activate NF-kb, which in turn governs the production of IL-8, MCP-1, and TNF-α [ 183 ]. IL-1β induces pericyte apoptosis via NF-κB activation and increases endothelial permeability in DR [ 184 ]. Moreover, IL-1β plays a relevant role in the degeneration of retinal capillaries [ 185 ] and is able to downregulate the interphotoreceptor retinoid-binding protein (IRBP), an essential protein for the maintenance of photoreceptors [ 19 ].…”

Section: Treatment Based On Targeting Inflammationmentioning

confidence: 99%

Neurovascular Unit: A New Target for Treating Early Stages of Diabetic Retinopathy

et al. 2021

View full text Add to dashboard Cite

The concept of diabetic retinopathy as a microvascular disease has evolved and is now considered a more complex diabetic complication in which neurovascular unit impairment plays an essential role and, therefore, can be considered as a main therapeutic target in the early stages of the disease. However, neurodegeneration is not always the apparent primary event in the natural story of diabetic retinopathy, and a phenotyping characterization is recommendable to identify those patients in whom neuroprotective treatment might be of benefit. In recent years, a myriad of treatments based on neuroprotection have been tested in experimental models, but more interestingly, there are drugs with a dual activity (neuroprotective and vasculotropic). In this review, the recent evidence concerning the therapeutic approaches targeting neurovascular unit impairment will be presented, along with a critical review of the scientific gaps and problems which remain to be overcome before our knowledge can be transferred to clinical practice.

show abstract

Interleukin-1β induces pericyte apoptosis via the NF-κB pathway in diabetic retinopathy

Cited by 37 publications

References 24 publications

IL-1β Implications in Type 1 Diabetes Mellitus Progression: Systematic Review and Meta-Analysis

IL-1β Implications in Type 1 Diabetes Mellitus Progression: Systematic Review and Meta-Analysis

Microglia: Key Players in Retinal Ageing and Neurodegeneration

Neurovascular Unit: A New Target for Treating Early Stages of Diabetic Retinopathy

Contact Info

Product

Resources

About