Interleukin-1β in hypothalamic paraventricular nucleus mediates excitatory renal reflex

Zheng, Fuqiang; Ye, Chao; Wan, Guo-Wei; Zhou, Bing; Tong, Ying; Lei, Jianzhen; Chen, Qi; Li, Yuehua; Kang, Yu-Ming; Zhu, Guo‐Qing

doi:10.1007/s00424-020-02461-7

Cited by 11 publications

(9 citation statements)

References 46 publications

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“…Capsaicin stimulates afferents and increases the afferent nerve activity at a low concentration, but causes denervation at a high concentration (Fitzgerald, 1983). The concentration of capsaicin in the present study was used to stimulate the renal afferents and cause ERR (Qiu et al, 2020;Ye et al, 2020;Zheng et al, 2020), which was much lower than the concentration used for denervation in previous studies (Fitzgerald, 1983;Foss et al, 2015). The capsaicin-induced ERR existed in the SHR at the ages of four, 12, and 24 weeks, indicating that the ERR is involved in the sympathetic activation and hypertension from the early stage to the sustained stage of hypertension in SHR.…”

Section: Discussionmentioning

confidence: 89%

“…Our previous study has shown that the renal infusion of capsaicin dose-dependently induces ERR in normal rats ( Ye et al, 2020 ). The dose of capsaicin at 1 nmol/min for 20 min was selected to induce ERR, and the vehicle for renal infusion had no significant effects on the RSNA, MAP, and HR ( Qiu et al, 2020 ; Ye et al, 2020 ; Zheng et al, 2020 ). At the age of 4 weeks, the early stage with slight or moderate hypertension, unilateral renal infusion of capsaicin caused immediate increases in the contralateral RSNA and MAP in both the WKY and SHR, lasting for at least 30 min.…”

Section: Resultsmentioning

confidence: 99%

“…Infusion of capsaicin into the upper, lateral, or lower parts of the kidney showed similar ERR effects ( Ye et al, 2020 ). Therefore, the cortico-medullary border of the lateral part of the kidney was selected for the infusion site in inducing ERR ( Qiu et al, 2020 ; Zheng et al, 2020 ). Intravenous infusion of the same dose of capsaicin failed to cause significant effects on the RSNA, mean arterial pressure (MAP), and heart rate (HR), excluding the possibility that the effects of the renal infusion of capsaicin might be caused by leaking into the blood circulation ( Ye et al, 2020 ).…”

Section: Methodsmentioning

confidence: 99%

“…Recently, we have shown that the chemical stimulation of kidney in normal rats with capsaicin causes an excitatory renal reflex (ERR), which results in the sympathetic activation and pressor responses ( Ye et al, 2020 ). The capsaicin-induced ERR is mediated by angiotensin II in the hypothalamic paraventricular nucleus (PVN), which acts on AT 1 R, and in turn activates NADPH oxidase, causing oxidative stress and the subsequent NFκB activation and IL-1β production in the PVN in normal rats ( Qiu et al, 2020 ; Zheng et al, 2020 ). The renal afferent input increases the activity of some neurons in the PVN ( Xu et al, 2015 ), and destruction of the PVN neurons abolishing the capsaicin-induced ERR ( Ye et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Dysregulation of the Excitatory Renal Reflex in the Sympathetic Activation of Spontaneously Hypertensive Rat

Zheng

Wang

et al. 2021

Front. Physiol.

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Excessive sympathetic activation plays crucial roles in the pathogenesis of hypertension. Chemical stimulation of renal afferents increases the sympathetic activity and blood pressure in normal rats. This study investigated the excitatory renal reflex (ERR) in the development of hypertension in the spontaneously hypertensive rat (SHR). Experiments were performed in the Wistar-Kyoto rat (WKY) and SHR aged at 4, 12, and 24 weeks under anesthesia. Renal infusion of capsaicin was used to stimulate renal afferents, and thus, to induce ERR. The ERR was evaluated by the changes in the contralateral renal sympathetic nerve activity and mean arterial pressure. At the age of 4 weeks, the early stage with a slight or moderate hypertension, the ERR was more enhanced in SHR compared with WKY. The pressor response was greater than the sympathetic activation response in the SHR. At the age of 12 weeks, the development stage with severe hypertension, there was no significant difference in the ERR between the WKY and SHR. At the age of 24 weeks, the later stage of hypertension with long-term several hypertensions, the ERR was more attenuated in the SHR compared with the WKY. On the other hand, the pressor response to sympathetic activation due to the ERR was smaller at the age of 12 and 24 weeks than those at the age of 4 weeks. These results indicate that ERR is enhanced in the early stage of hypertension, and attenuated in the later stage of hypertension in the SHR. Abnormal ERR is involved in the sympathetic activation and the development of hypertension.

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Section: Discussionmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dysregulation of the Excitatory Renal Reflex in the Sympathetic Activation of Spontaneously Hypertensive Rat

Zheng

Wang

et al. 2021

Front. Physiol.

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“…Our findings in this paper and previous publications [14,49,51] as well as those of other authors [28,29] argue for a sympatho-inhibitory effect of renal afferents under normal conditions and a loss of sympatho-inhibition in pathological situations. However, we are well aware that there are also reports [50,59,62] suggesting sympatho-excitatory influences of afferent renal nerves. Probably, we must assume that both populations exist, without being able to say so far exactly when which population exerts which influence on central nervous sympathetic production under which stimulation conditions.…”

Section: Stimulation Of Renal Afferent Neurons?mentioning

confidence: 99%

Neurogenic substance P—influences on action potential production in afferent neurons of the kidney?

Rodionova

Hilgers

Linz

et al. 2021

Pflugers Arch - Eur J Physiol

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We recently showed that a substance P (SP)–dependent sympatho-inhibitory mechanism via afferent renal nerves is impaired in mesangioproliferative nephritis. Therefore, we tested the hypothesis that SP released from renal afferents inhibits the action potential (AP) production in their dorsal root ganglion (DRG) neurons. Cultured DRG neurons (Th11-L2) were investigated in current clamp mode to assess AP generation during both TRPV1 stimulation by protons (pH 6) and current injections with and without exposure to SP (0.5 µmol) or CGRP (0.5 µmol). Neurons were classified as tonic (sustained AP generation) or phasic (≤ 4 APs) upon current injection; voltage clamp experiments were performed for the investigation of TRPV1-mediated inward currents due to proton stimulation. Superfusion of renal neurons with protons and SP increased the number of action potentials in tonic neurons (9.6 ± 5 APs/10 s vs. 16.9 ± 6.1 APs/10 s, P < 0.05, mean ± SD, n = 7), while current injections with SP decreased it (15.2 ± 6 APs/600 ms vs. 10.2 ± 8 APs/600 ms, P < 0.05, mean ± SD, n = 29). Addition of SP significantly reduced acid-induced TRPV1-mediated currents in renal tonic neurons (− 518 ± 743 pA due to pH 6 superfusion vs. − 82 ± 50 pA due to pH 6 with SP superfusion). In conclusion, SP increased action potential production via a TRPV1-dependent mechanism in acid-sensitive renal neurons. On the other hand, current injection in the presence of SP led to decreased action potential production. Thus, the peptide SP modulates signaling pathways in renal neurons in an unexpected manner leading to both stimulation and inhibition of renal neuronal activity in different (e.g., acidic) environmental contexts.

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Placental ischemia-upregulated angiotensin II type 1 receptor in hypothalamic paraventricular nucleus contributes to hypertension in rat

Issotina Zibrila,

Zhou,

Wang

et al. 2024

Pflugers Arch - Eur J Physiol

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Interleukin-1β in hypothalamic paraventricular nucleus mediates excitatory renal reflex

Cited by 11 publications

References 46 publications

Dysregulation of the Excitatory Renal Reflex in the Sympathetic Activation of Spontaneously Hypertensive Rat

Dysregulation of the Excitatory Renal Reflex in the Sympathetic Activation of Spontaneously Hypertensive Rat

Neurogenic substance P—influences on action potential production in afferent neurons of the kidney?

Placental ischemia-upregulated angiotensin II type 1 receptor in hypothalamic paraventricular nucleus contributes to hypertension in rat

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