Interleukin-1β gene polymorphism in women with vulvar vestibulitis syndrome

Gerber, Stefan; Bongiovanni, Ann Marie; Ledger, William; Witkin, Steven S.

doi:10.1016/s0301-2115(02)00276-2

Cited by 85 publications

(53 citation statements)

References 17 publications

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“…Working with physical therapists, Reissing et al [50] found that women with vaginismus demonstrated significantly higher vaginal/pelvic muscle tone and lower muscle strength than women with PVD or controls. Single Bcandidate^gene research has been performed in the field of vulvodynia, and genetic polymorphisms have been linked to the development of vulvar pain [51][52][53][54][55][56]. Although to date, there is evidence for heritability in other chronic pain syndromes [57], no heritability studies have been performed in the context of vulvodynia.…”

Section: Biomedical Factorsmentioning

confidence: 99%

Female Sexual Pain Disorders: a Review of the Literature on Etiology and Treatment

Bergeron

Corsini‐Munt

Aerts

et al. 2015

Curr Sex Health Rep

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Female sexual pain disorders, although highly prevalent and increasingly studied, remain a distressing complaint for women and their partners. Empirical evidence points to a multifactorial conceptualization of the etiology, course, and associated difficulties of sexual pain; thus, treatment options span the medical, pelvic floor rehabilitation psychological and multimodal. Given the interpersonal context in which sexual pain occurs, recent work has underscored the importance of considering the dyadic framework in research and treatment. This review presents understanding from across disciplines focusing on the impact of sexual pain on the woman and the couple, proposed etiologic pathways and risk factors related to its development and course, and current treatment options. Recommendations for research point to an urgency for multidisciplinary exchanges in the development of conceptual models and refinement of targeted interventions.

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Section: Biomedical Factorsmentioning

confidence: 99%

Female Sexual Pain Disorders: a Review of the Literature on Etiology and Treatment

Bergeron

Corsini‐Munt

Aerts

et al. 2015

Curr Sex Health Rep

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“…Sebuah penelitian mendapatkan prevalensi yang mencapai 5-66%. [1][2][3][4][5][6] Penelitian lain malah menunjukkan angka kejadian mencapai 90% pada anak yang kedua orangtuanya mengalami SAR. [7][8][9][10] Gambaran klinis stomatitis aftosa rekuren dibagi menjadi tiga kelompok, yaitu minor aphtae, mayor aphtae, dan herpetiform ulcers.…”

Section: Pendahuluanunclassified

“…[7][8][9][10] Gambaran klinis stomatitis aftosa rekuren dibagi menjadi tiga kelompok, yaitu minor aphtae, mayor aphtae, dan herpetiform ulcers. 3,4 Lesi SAR menimbulkan rasa nyeri, bentuknya bulat atau oval dengan pusat nekrotik yang dangkal disertai dengan pseudomembran warna putih kekuningan yang dikelilingi oleh daerah eritematous yang mengalami peninggian. [5][6][7][8] Etiologi penyakit ini masih belum jelas, [1][2][3][4][5][6][7][8][9] namun banyaknya laporan mengenai rekurensi penyakit ini pada masa sebelum, saat, dan pasca menstruasi memunculkan dugaan adanya pengaruh hormon terhadap terjadinya SAR.…”

Section: Pendahuluanunclassified

“…3,4 Lesi SAR menimbulkan rasa nyeri, bentuknya bulat atau oval dengan pusat nekrotik yang dangkal disertai dengan pseudomembran warna putih kekuningan yang dikelilingi oleh daerah eritematous yang mengalami peninggian. [5][6][7][8] Etiologi penyakit ini masih belum jelas, [1][2][3][4][5][6][7][8][9] namun banyaknya laporan mengenai rekurensi penyakit ini pada masa sebelum, saat, dan pasca menstruasi memunculkan dugaan adanya pengaruh hormon terhadap terjadinya SAR. Meskipun masih kontroversi, namun beberapa penelitian diantaranya Jones dan Mason 11 melaporkan adanya hubungan antara SAR dengan siklus menstruasi dan jumlah penderita wanita yang mencapai dua kali dibanding laki-laki.Croley dan Miers 12 juga meneliti pengaruh hormonestrogenyang ternyata merangsang maturasi lengkap sel epitel mukosa mulut dan progesteron yang menghambatnya.…”

Section: Pendahuluanunclassified

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Hubungan antara level estradiol dan progesterone dengan stomatitis aftosa rekuren Relation between estradiol and progesterone hormone level with recurrent aphthous stomatitis

Sumintarti

Marlina

2012

J Dentomaxillofac Sci

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Recurrent aphthous stomatitis (RAS) is a common inflammatory oral disease. The etiology remains unclear ABSTRAKStomatitis aftosa rekuren (SAR) adalah penyakit rongga mulut yang paling sering dijumpai di masyarakat. Etiologi penyakit ini masih belum jelas, namun banyaknya laporan mengenai rekurensi penyakit ini pada masa sebelum, saat, dan pasca menstruasi memunculkan dugaan adanya pengaruh hormon terhadap rekurensi terjadinya SAR. Penelitian ini bertujuan untuk mengetahui sejauh mana hubungan antara perubahan hormonal yang berkaitan dengan masa menstruasi, khususnya progesteron dan estradiol sebagai hormon estrogen yang paling banyak dijumpai dalam darah. Dengan metode purposive sampling, didapatkan 15 subjek yang bersedia ikut dalam penelitian. Dari kuisioner, diperoleh data sehingga dapat ditentukan karakteristik menstruasi dan karakteristik rekurensi ulser pada subjek. Selanjutnya subjek diminta melakukan pemeriksaan estradiol dan progesteron di laboratorium. Hasilnya, dari 15, hanya satu sampel dengan level estradiol di atas normal (6,7%). Sedangkan sampel yang lain menunjukkan kadar yang normal (93,3%). Untuk level progesteron, tiga sampel (20%) yang normal sedang 12 sampel lain (80%) menunjukkan nilai di bawah normal. Disimpulkan bahwa kadar estradiol penderita SAR, dengan pola menstruasi teratur cenderung normal, sedangkan kadar progesteron kurang dari normal. Kata kunci: estradiol, estrogen, progesteron, stomatitis aftosa rekuren Koresponden: Sumintarti, Bagian Oral Medicine, Fakultas Kedokteran Gigi Universitas Hasanuddin, Jl. Kandea No. 5, Makassar, Indonesia. E-email: mien.sugiharto@yahoo.com PENDAHULUANRecurrent aphthous stomatitis atau stomatitis aftosa rekuren (SAR) adalah penyakit rongga mulut yang paling sering dijumpai di masyarakat, dengan prevalensi mencapai 20-25%. Sebuah penelitian mendapatkan prevalensi yang mencapai 5-66%.

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“…57 In theory, some triggering event (i.e. Candida infection, human papilloma virus (HPV) infection, toxins, semen, or laser surgery 51 precipitates an inflammatory reaction which is not adequately controlled. The prolonged inflammatory reaction induces prolonged firing of the sympathetic, Type C nerve fibers 57 ; this in turn causes the wide dynamic-range neurons in the brain to respond abnormally, such that mild stimuli are perceived as pain.…”

mentioning

confidence: 99%

Chronic Pain of the Vulva without Dermatologic Manifestations: Distinguishing among a Spectrum of clinical Disorders

Farage

Miller

Summers

et al. 2010

Clin Med�Insights�Womens�Health

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Abstract:The causes of chronic vulvar pain are many and when not accompanied by obvious physical signs they are difficult to unravel. Many common vulvar dermatoses can manifest without obvious erythema or mucocutaneous lesions, as can some less common disorders of both infectious and allergic origin. In addition localized and generalized vulvar dysesthesia, recently defined chronic pain syndromes of neurogenic origin, can also occur in the vulvar area. Chronic vulvovaginal symptoms in early stages are often presumptuously labeled as vulvovaginal candidiasis (VVC) by patients and clinicians alike, which can delay accurate diagnosis. When presented with chronic vulvar pain unaccompanied by verifiable signs, the clinician must effect a sensitive integration of a detailed medical history, including temporal associations of all potential exposures, with more definitive diagnostic tools. Effective use of those available tools can improve initial diagnosis, thus allowing prompt initiation of effective therapy. Optimal therapy will recognize the significant psychological distress that accompanies any chronic pain syndrome.

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Interleukin-1β gene polymorphism in women with vulvar vestibulitis syndrome

Cited by 85 publications

References 17 publications

Female Sexual Pain Disorders: a Review of the Literature on Etiology and Treatment

Female Sexual Pain Disorders: a Review of the Literature on Etiology and Treatment

Hubungan antara level estradiol dan progesterone dengan stomatitis aftosa rekuren Relation between estradiol and progesterone hormone level with recurrent aphthous stomatitis

Chronic Pain of the Vulva without Dermatologic Manifestations: Distinguishing among a Spectrum of clinical Disorders

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