INTERLEUKIN 1β AS STIMULATOR OF THE RAT THYMUS

Artico, Marco; Cavallotti, Carlo; Cameroni, Mauro; Cavallotti, Daniela

doi:10.1006/cyto.2001.0924

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…Thymic RE cells also produce numerous cytokines, including IL-1, -3, -6, -7 and G-CSF, M-CSF, which likely are important during the various stages of thymocyte activation and differentiation (26,29,40).…”

Section: Endocrine Function Of the Thymus Microenvironmentmentioning

confidence: 99%

Neuro-immune modulation of the thymus microenvironment (Review)

Mignini

Sabbatini

Mattioli

et al. 2014

International Journal of Molecular Medicine

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The thymus is the primary site for T-cell lympho-poiesis. Its function includes the maturation and selection of antigen specific T cells and selective release of these cells to the periphery. These highly complex processes require precise parenchymal organization and compartmentation where a plethora of signalling pathways occur, performing strict control on the maturation and selection processes of T lymphocytes. In this review, the main morphological characteristics of the thymus microenvironment, with particular emphasis on nerve fibers and neuropeptides were assessed, as both are responsible for neuro-immune‑modulation functions. Among several neurotransmitters that affect thymus function, we highlight the dopaminergic system as only recently has its importance on thymus function and lymphocyte physiology come to light.

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Section: Endocrine Function Of the Thymus Microenvironmentmentioning

confidence: 99%

Neuro-immune modulation of the thymus microenvironment (Review)

Mignini

Sabbatini

Mattioli

et al. 2014

International Journal of Molecular Medicine

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Galactoside-specific plant lectin, Viscum album agglutinin-I induces enhanced proliferation and apoptosis of murine thymocytes in vivo

et al. 2003

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Effects of Mistletoe Extract on Murine Thymocytes in vivo and on Glucocorticoid-Induced Cell Count Reduction

Hajtò

Berki²,

Pàlinkàs³

et al. 2006

Complement Med Res

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Background: Mistletoe extracts are widely used in cancer patients due to their cytostatic and immunomodulatory effects. Essential components include mistletoe lectins which act as biomodulators with proinflammatory and apoptosisinducing effects. This study investigates the acute and longterm effects of standardized mistletoe extract (Iscador® M spec 5 mg) on thymocyte subpopulations and peripheral T-cells using a murine (Balb/c) model. Materials and Methods: Using cell surface CD4/CD8 staining and flow cytometry, we followed the changes in CD4-CD8- double-negative (DN), CD4+CD8+ double-positive (DP) and CD4+ or CD8+ single-positive (SP) T-cells 24 h after single or repeated injections of 3 different dilutions (1:12, 1:60, 1:300) corresponding to 2.1, 0.42 and 0.08 mg/kg of Iscador. Thymocyte apoptosis was detected by flow cytometry using Annexin V and propidium iodide. Results: 24 h after a single injection of the 2 lower doses, the number of DN thymocytes increased significantly with an enhanced ratio of apoptotic cells. Following administration of the lowest dose, in peripheral blood the CD4+/CD8+ ratio was elevated. In the long-term trial, Balb/c mice were treated twice a week with 3 different doses of Iscador +/- 20 mg/kg of dexamethasone (DX), resulting in significantly enhanced DN thymocytes and elevated levels of apoptotic cells after treatment with the 2 lower doses. Iscador also inhibited the DX-induced reduction in the thymic DN cell count, as well as the DX-induced decrease in the CD4+/CD8+ ratio and CD4+ in the peripheral blood. Conclusion: Our results suggest that standardized mistletoe extract modulates proliferation and apoptosis of thymocytes in a dose-dependent manner and may act lymphoprotective during DX treatment.

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INTERLEUKIN 1β AS STIMULATOR OF THE RAT THYMUS

Cited by 3 publications

References 11 publications

Neuro-immune modulation of the thymus microenvironment (Review)

Neuro-immune modulation of the thymus microenvironment (Review)

Galactoside-specific plant lectin, Viscum album agglutinin-I induces enhanced proliferation and apoptosis of murine thymocytes in vivo

Effects of Mistletoe Extract on Murine Thymocytes in vivo and on Glucocorticoid-Induced Cell Count Reduction

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