Interleukin-1α-converting enzyme (ICE) and related cell death genes ICErel-II and ICErel-III map to the same PAC clone at band 11q22.2-22.3

Nasir, Jamal; Theilmann, Jane; Vaillancourt, John P.; Munday, Neil A.; Ali, Ambereen; Scherer, Stephen W.; Beatty, Barbara; Nicholson, Donald W.; Hayden, Michael R.

doi:10.1007/s003359900514

Cited by 13 publications

(5 citation statements)

References 25 publications

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“…In the three species, the gene order and orientation of three gene loci (caspase-1,4,12) are the same, but in human the caspase-1 gene seems to be distinctly amplified (11.15-21, for the locus nomenclature, please see the legend of Table 3). which confirmed and extended other reports [6,15]. It is worth mentioning that other than 11.15 and 11.18, all other gene loci either contain only ICE domain or only CARD domain, and at least some of them were reported to be the competitive inhibitors of functional caspases [6].…”

Section: Domain/motifsupporting

confidence: 87%

“…We defined a distance criterion to determine which apoptosis genes are clustered, and observed that about one-third of mammalian apoptosis related genes neighbor each other. Although some previous studies reported the gene clustering cases in human or mouse [15][16][17][18], our analysis discovered all the gene loci clusters and found most of them are conserved in the three mammals. At the same time, comparing the loci clusters among the three species revealed some species-specific gene amplification or gene loss, which indicated some genes were tandem duplicated and were relative to some species-specific functions.…”

Section: Discussioncontrasting

confidence: 76%

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Comparative Study of Apoptosis-related Gene Loci in Human, Mouse and Rat Genomes

Yin¹,

Zhang²,

Yu³

et al. 2005

ABBS

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Many genes are involved in mammalian cell apoptosis pathway. These apoptosis genes often contain characteristic functional domains, and can be classified into at least 15 functional groups, according to previous reports. Using an integrated bioinformatics platform for motif or domain search from three public mammalian proteomes (International Protein Index database for human, mouse, and rat), we systematically cataloged all of the proteins involved in mammalian apoptosis pathway. By localizing those proteins onto the genomes, we obtained a gene locus centric apoptosis gene catalog for human, mouse and rat. Further phylogenetic analysis showed that most of the apoptosis related gene loci are conserved among these three mammals. Interestingly, about one-third of apoptosis gene loci form gene clusters on mammal chromosomes, and exist in the three species, which indicated that mammalian apoptosis gene orders are also conserved. In addition, some tandem duplicated gene loci were revealed by comparing gene loci clusters in the three species. All data produced in this work were stored in a relational database and may be viewed at http://pcas.cbi.pku.edu.cn/database/apd.php.

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Section: Domain/motifsupporting

confidence: 87%

Section: Discussioncontrasting

confidence: 76%

Comparative Study of Apoptosis-related Gene Loci in Human, Mouse and Rat Genomes

Yin¹,

Zhang²,

Yu³

et al. 2005

ABBS

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“…These include the caspases-1, -4, -5 gene cluster on 11q22.2-q22.3 and the caspases-8, -10, cFLIP/Usurpin gene cluster on 2q33-q34. 71,72 (cFLIP/Usurpin (aka CASH, Casper, CLARP, FLAME-1, I-FLICE, MRIT) is homologous to caspases -5, -8 and -10, except that substrate binding and catalytic determinants are absent, making it a dominant-negative death repressor.) The human counterparts of murine caspases-11, -12 and - 14 have not yet been identified (although murine caspase-12 may be equivalent to human caspase-5)…”

Section: The Mammalian Caspase Gene Family and Functional Sub-familiesmentioning

confidence: 99%

Caspase structure, proteolytic substrates, and function during apoptotic cell death

1999

Cell Death Differ

1,400

1,014

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Caspases play an essential role during apoptotic cell death. These enzymes define a new class of cysteine proteases and comprise a multi-gene family with more than a dozen distinct mammalian family members. The discrete and highly limited subset of cellular polypeptides that are cleaved by these proteases is sufficient to account for the majority of cellular and morphological events that occur during cell death. In some cases, caspases also play a contributory role in escalating the propensity for apoptosis, and in doing so may exacerbate disease pathogenesis.

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“…They can also be grouped on the basis of the substrate preference, the length of their prodomain, or by participation in apoptosis or inflammation. Two major gene clusters have been identified: one maps to chromosome 11q22.2-q22.3 and com-prises genes encoding caspases-1, -4, -5; while the second is located on chromosome 2q33-q34 and encodes caspases-8 and -10 [Nasir et al, 1997;Rasper et al, 1998].…”

Section: Caspases (Fig 1)mentioning

confidence: 99%

Molecular machinery and signaling events in apoptosis

et al. 2001

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Apoptosis is a process of major biomedical interest, since its ineffectiveness or inappropriate activation appears to be involved in the pathogenesis of a broad variety of human diseases (neoplasia, autoimmune disorders, viral and neurodegenerative diseases, to name a few). On this topic, extensive experimental work has allowed in the past years the clarification of the complex biochemical machinery that commits a cell to apoptosis and executes the death program. As to the signaling mechanisms, it is now evident that apoptosis can be initiated by different stimuli and/or genetic programs that are differentially decoded inside the cell. While the past years have witnessed a major advancement on this topic, much still needs to be learned of the cross-talk between the various signaling pathways involved in decoding the apoptotic stimuli, as well as the activation of other cell functions. In this review we first describe the properties and activation mechanisms of the caspases, the effector proteases of apoptosis. In the second part we discuss the current evidence for the involvement of calcium, the ubiquitous second-messenger decoding a wide variety of physiological stimuli, and highlight the potential targets of the apoptotic calcium signal. Drug Dev. Res. 52:558-570, 2001.

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Interleukin-1α-converting enzyme (ICE) and related cell death genes ICErel-II and ICErel-III map to the same PAC clone at band 11q22.2-22.3

Cited by 13 publications

References 25 publications

Comparative Study of Apoptosis-related Gene Loci in Human, Mouse and Rat Genomes

Comparative Study of Apoptosis-related Gene Loci in Human, Mouse and Rat Genomes

Caspase structure, proteolytic substrates, and function during apoptotic cell death

Molecular machinery and signaling events in apoptosis

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