Interleukin-1beta and Caspase-3 expression serve as independent prognostic markers for metastasis and survival in oral squamous cell carcinoma

Singh, Preeti; Augustine, Dominic; Rao, Roopa S; Patil, Shankargouda; Sowmya, S; Haragannavar, Vanishri C; Nambiar, Shwetha

doi:10.3233/cbm-190149

Cited by 7 publications

(9 citation statements)

References 43 publications

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“…Descriptive summaries of the included studies, listed chronologically from the oldest publication date, are displayed in Table 1 . The data were collected from a period spanning 1970 to 2019, while the year of publication ranged from 2005 to 2019 [ 5 , 7 , 10 , 14 , 16 , 20 , 21 , 26 , 27 , 37 , 50 , 57 , 58 , 61 , 70 , 71 , 72 , 73 ]. Sample sizes ranged between 20 and 246 [ 5 , 7 , 10 , 14 , 16 , 20 , 21 , 26 , 27 , 37 , 50 , 57 , 58 , 61 , 70 , 71 , 72 , 73 ].…”

Section: Resultsmentioning

confidence: 99%

“…The data were collected from a period spanning 1970 to 2019, while the year of publication ranged from 2005 to 2019 [ 5 , 7 , 10 , 14 , 16 , 20 , 21 , 26 , 27 , 37 , 50 , 57 , 58 , 61 , 70 , 71 , 72 , 73 ]. Sample sizes ranged between 20 and 246 [ 5 , 7 , 10 , 14 , 16 , 20 , 21 , 26 , 27 , 37 , 50 , 57 , 58 , 61 , 70 , 71 , 72 , 73 ]. The studies were conducted in 14 different countries across Europe, South America and Asia.…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies fully complied with the REMARKS guidelines. According to aforementioned >4 cut-off point, all of these eight studies were considered of good quality ( Table S1 [ 5 , 14 , 27 , 37 , 57 , 70 , 71 , 73 ]). Low risk of bias regarding clinical data was found in one study.…”

Section: Resultsmentioning

confidence: 99%

“…Of interest is the fact that cleaved Caspase 3 showed a mean increase in HNC when compared with OPMD: 73.3% (38.6–88.3) versus 22.9% (7.1–38.7) of high/moderate staining, respectively. The standard deviation can be justified by the difference in cut-off, antibodies used, as well as the type, location, phenotype and other individual characteristics of each study ( Figure 3 ; Table S2 [ 5 , 7 , 14 , 20 , 26 , 27 , 57 , 58 , 61 , 70 , 72 , 73 ]; Table S3 [ 10 , 16 , 21 , 37 , 50 , 57 , 71 ]).…”

Section: Resultsmentioning

confidence: 99%

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Caspase 3 and Cleaved Caspase 3 Expression in Tumorogenesis and Its Correlations with Prognosis in Head and Neck Cancer: A Systematic Review and Meta-Analysis

Silva

Padín-Iruegas

Caponio

et al. 2022

IJMS

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Head and neck cancer (HNC) is an ascending and agressive disease. The search for new molecular markers is emerging to solve difficulties in diagnosis, risk management, prognosis and effectiveness of treatments. Proteins related to apoptotic machinery have been identified as potential biomarkers. Caspase 3 is the main effector caspase and has a key role in apoptosis. The objective of this systematic review and meta-analysis is to review studies that analyze changes in Caspase 3 and Cleaved Caspase 3 expression both in oral premalignant disorders (OPMD) as well as in head and neck cancer (HNC). This study also proposes to review the prognostic values associated with HNC according to the expression of Caspase 3. Medline (via PubMed), EMBASE, Scopus, Cochrane, Web of Science and Grey Literature Database were screened from inception to june of 2022 and 18 studies were selected and 8 were included in the prognostic meta-analysis. Results related to the comparison of Caspase 3 expression demonstrated similar expression of Caspase 3 in HNC, with an average of 51.9% (9.5-98.1) showing high/moderate expression compared to 45.7% (14.6-84.7) in OPMD. Of interest, Cleaved Caspase 3 resulted incresed in HNC when compared with OPMD, being 73.3% (38.6-88.3) versus 22.9% (7.1-38.7). Pooled Fixed effect of HR values (95% CI) for OS related to Caspase 3 IHC expression in HNC patients was 1.48 (95% CI 0.95-2.28); also, the rate of heterogeneity was low, as revealed by I2 = 31%. For DFS was 1.07 (95% CI 0.79-1.45) with I2 = 0% and DSS showed a HR of 0.88 (95% CI 0.69-1.12) with I2 = 37%. Caspase 3 and Cleaved Caspase 3 expression could be linked with malignancy progression, but the expression of Caspase 3 did not influence the prognosis of patients with HNC.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Caspase 3 and Cleaved Caspase 3 Expression in Tumorogenesis and Its Correlations with Prognosis in Head and Neck Cancer: A Systematic Review and Meta-Analysis

Silva

Padín-Iruegas

Caponio

et al. 2022

IJMS

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“…The authors observed that proteins derived from the inflammasome were involved in the protection against squamous cell carcinoma since their loss hinders the development of the antitumor response. On the other hand, and consistent with the dual role of this cytokine, Dantas et al [ 31 ] observed how IL-1β immunostaining was significantly higher in metastases of oral carcinomas and lymph nodes than in squamous epithelium of tumor resection margins; while Singh et al [ 32 ] described how the immunostaining for IL-1β in non-metastatic oral carcinomas was weak in more than half of the cases. Therefore, the presence of IL-1β in oral epithelial tissues remains controversial.…”

Section: Discussionmentioning

confidence: 73%

Expression of Interleukin-1ß and Interleukin-8 in Oral Potentially Malignant Disorders and Carcinomas

López-Labady

Bologna‐Molina²,

Dorrego³

2021

Front. Oral. Health

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Objective: To evaluate interleukin-1ß (IL-1ß) and interleukin-8 (IL-8) epithelial expressions in potentially malignant disorders of the oral mucosa as malignant predictive markers.Study design: About 55 tissues embedded in paraffin, comprising 15 oral lichen planus (OLP) lesions, 15 leukoplakias, 15 oral squamous cell carcinomas (OSCC), and 10 samples of normal oral mucosa were included in the study. IL-1ß and 8 expressions were assessed by immunohistochemistry using antibodies antihuman IL-1ß human (sc-7884, Santa Cruz® H-153) and antihuman IL-8 (ab7747, abcam®). The number of positive cells was compared using Student's t-test. Any p-value < 0.05 was considered statistically significant.Results: Nuclear and cytoplasmatic keratinocyte staining were positive for both cytokines in all study groups. However, a statistically significant decrease was observed within all cases compared to normal mucosa, both staining for IL-1β and 8. Moreover, IL-8 showed significant differences between OLP and leukoplakia, and when compared to OSCC.Conclusions: Oral epithelial expression of IL-1β and 8 seems to decrease when the malignant transformation of the oral mucosa increases.

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The Role of Inflammation-Associated Factors in Head and Neck Squamous Cell Carcinoma

Li,

Zeng,

Liu

et al. 2023

JIR

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Head and neck squamous cell carcinoma (HNSCC), which originates in the head or neck tissues, is characterized by high rates of recurrence and metastasis. Inflammation is important in HNSCC prognosis. Inflammatory cells and their secreted factors contribute to the various stages of HNSCC development through multiple mechanisms. In this review, the mechanisms through which inflammatory factors, signaling pathways, and cells contribute to the initiation and progression of HNSCC have been discussed in detail. Furthermore, the diagnostic and therapeutic potential of targeting inflammation in HNSCC has been discussed to gain new insights into improving patient prognosis.

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Interleukin-1beta and Caspase-3 expression serve as independent prognostic markers for metastasis and survival in oral squamous cell carcinoma

Cited by 7 publications

References 43 publications

Caspase 3 and Cleaved Caspase 3 Expression in Tumorogenesis and Its Correlations with Prognosis in Head and Neck Cancer: A Systematic Review and Meta-Analysis

Caspase 3 and Cleaved Caspase 3 Expression in Tumorogenesis and Its Correlations with Prognosis in Head and Neck Cancer: A Systematic Review and Meta-Analysis

Expression of Interleukin-1ß and Interleukin-8 in Oral Potentially Malignant Disorders and Carcinomas

The Role of Inflammation-Associated Factors in Head and Neck Squamous Cell Carcinoma

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