Interleukin-1beta -511T&gt;C genetic variant contributes to recurrent pregnancy loss risk and peripheral natural killer cell proportion

Kim, Jung O; Lee, Woo Sik; Lee, Bo Eun; Jeon, Young Joo; Kim, Young Ran; Jung, Sang Hee; Chang, Sung Woon; Kim, Nam Keun

doi:10.1016/j.fertnstert.2014.03.037

Cited by 26 publications

(23 citation statements)

References 37 publications

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“…Ultimately, 31 studies were included (Table 1): 30 articles were used for the meta-analysis, and one article only applied to the literature review because it was the only report of these interleukins[8, 10, 18]. Seven articles assessed IL-1β and included -511C/T, +3593C/T, -1903C/T, -31C/T and -5887C/T[1, 4, 19–23]; twelve articles evaluated IL-6 gene promoter polymorphisms, including -174G/C, -634C/G, -572G/C, -597G/A, -1363G/T, and -2954G/C[3, 5, 14, 24–32]; eleven articles assessed IL-10 gene promoter polymorphisms, including -1082G/A, -592C/A, -819T/C, and -536A/G[3, 14, 23, 24, 30, 31, 33–37]; and five articles evaluated IL-18 gene promoter polymorphisms and included -137G/C, -607C/A, -119A/C, -105G/A, and -656C/A[9, 38–41]. …”

Section: Resultsmentioning

confidence: 99%

“…The five included studies had a total of 1052 patients and 915 controls for analysis[4, 20–23]. Calculation of the ORs and 95% CIs for the fixed effects model showed a significant association under a recessive genetic model of IL-1β (-511C/T) polymorphism (P = 0.02, OR = 0.77, 95% CI [0.62,0.96] Fig 2) and no significant association under a dominant genetic model (P = 0.59, OR = 0.87, 95% CI [0.53,1.43], S1 Fig).…”

Section: Resultsmentioning

confidence: 99%

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Association between Genetic Polymorphisms in Interleukin Genes and Recurrent Pregnancy Loss – A Systematic Review and Meta-Analysis

Zhang

Bao

et al. 2017

PLoS ONE

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Interleukins are a group of immunomodulatory proteins that mediate a variety of immune reactions in the human body. To investigate the association between interleukin gene polymorphisms and recurrent pregnancy loss (RPL), we reviewed 21 studies from MEDLINE, EMBASE, OVID SP and PubMed to evaluate RPL-related interleukin gene polymorphisms. Meta-analysis was performed on 12 of the polymorphisms, and a review included the others. Our integrated results indicated that IL-1β (-511C/T) (P = 0.02, 95% CI 0.77[0.62,0.96]), IL-6 (-634C/G) (P<0.001, 95% CI 2.91[2.01,4.22]), IL-10 (-1082G/A, –819T/C) (P = 0.01, 95% CI 0.80[0.67,0.96]; P<0.01, 95% CI 0.66[0.49,0.89]), and IL-18 (-137G/C, -105G/A) (P<0.01, 95% CI 1.69[1.24,2.31]; P = <0.01, 95% CI 1.41[1.17,1.70]) consistently associated with RPL after meta-analysis. IL-17A rs2275913 and IL-17F rs763780, IL-21 rs2055979 and rs13143866, IL-1β (-31C/T), IL-6 (-2954G/C), and IL-10 (-536A/G) were reported only once as having a significant association with RPL. The potential mechanism underlying miscarriage and these polymorphisms and future research directions are also discussed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Association between Genetic Polymorphisms in Interleukin Genes and Recurrent Pregnancy Loss – A Systematic Review and Meta-Analysis

Zhang

Bao

et al. 2017

PLoS ONE

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“…Potentially relevant congenital Mullerian tract anomalies include unicornuate, didelphic, bicornuate, septate or arcuate uteri. The presence of a uterine septum was not only the most prevalent congenital defect, but also the only congenital defect to be more common in patients with primary RM, occurring in this group at more than double the rate of septal defects among the women in the general population [5,13,21,29,36,67].…”

Section: Anatomymentioning

confidence: 94%

“…Furthermore, the study of genes involved in immune response (IFNG, IL10, KIR2DS2, KIR2DS3, KIR2DS4, MBL, TNF), coagulation (F2, F5, PAI-1, PROZ), metabolism (GSTT1, MTHFR) and angiogenesis (NOS3, VEGFA) have been thoughtfully assessed without finding a clear association with RM [35,36].…”

Section: Genetic Abnormalities Embryonic Chromosomal Abnormalitiesmentioning

confidence: 99%

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Recurrent Miscarriage: A Review

Barrenetxea¹

2017

RMGO

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pregnancy events [2]. Clinical miscarriages may be subdivided into early clinical pregnancy losses (before gestational week 12) and late clinical pregnancy losses (gestational weeks 12 to 21). The term miscarriage is preferred rather than abortion both by patients and physicians, although "spontaneous abortion" is still used in scientific literature [3,4].For more than 30 years, controversy has existed on the number of miscarriages required to define RM and when diagnostic testing is warranted [5] EpidemiologyEarly pregnancy loss is perhaps the most common obstetric complication, occurring in over two-thirds of human conceptions. Approximately 15 -20% of all clinically recognized pregnancies will end in a miscarriage [4,9,10]. However, prospective cohort studies using sensitive and specific daily urinary hCG assays in women trying to conceive have demonstrated that only around one-third of conceptions progress to a live birth. Most of the losses occur before the clinical recognition of pregnancy as implantation failures. An estimated 30% of human conceptions are lost prior to implantation and a further 30% following implantation but before the missed menstrual period, that is in the third or fourth week of gestation. These are often termed preclinical losses [11].The risk of sporadic miscarriage between 6 and 12 weeks of gestation in women less than 35 years of age is 9% to 12%. The risk increases with age. In women older than 40 years of age, the sporadic miscarriage rate approaches 50%. Late losses between 12 and 22 weeks occur less frequently and constitute around 4% of pregnancy outcomes [4,9].Compared to sporadic miscarriage the prevalence of RM is considerably lower irrespective of whether biochemical losses are included or not. Approximately 1% of all women trying to conceive have recurrent miscarriage, defined as three previous miscarriages; when recurrent miscarriage is defined as two previous miscarriages, the proportion rises to 3% [12,13]. EtiologyMultiple potential etiologies for RM have been described (Table 1). As a consequence, several recommendations have been published regarding the evaluation and management of RM [3].The potential etiologies of RM can be divided into embryologically driven causes (mainly due to an abnormal embryonic karyotype) and maternally driven causes which affect the endometrium and/or placental development [14,15]. Thus, studies that focus on RM have Barrenetxea G, et al., J Reprod Med Gynecol Obstet 2017 AbstractHuman reproduction is characterized by its inefficiency. The loss of pregnancy at any stage can be a devastating experience and particular sensitivity is required in assessing and counseling couples with Recurrent Miscarriage (RM). Recurrent Miscarriage (RM) represents a clinical challenge for physicians not only because there are multiple possible etiologies, but also because the diagnostic testing is costly and time consuming. Despite several well-known etiologic factors, the cause of RM cannot be determined in almost 50% of cases. Multiple potential etiolo...

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Association between cytokine polymorphisms and recurrent pregnancy loss: A review of current evidence

Stavros,

Panagopoulos,

Machairiotis

et al. 2024

Intl J Gynecology & Obste

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Cytokines are a type of protein that play an important role in the immune response and can also affect many physiological processes in the body. Cytokine polymorphisms refer to genetic variations or mutations that occur within the genes that code for cytokines, which may affect the level of cytokine production and function. Some cytokine polymorphisms have been associated with an increased risk of developing certain diseases, while others may be protective or have no significant effect on health. In recent years, the role of cytokine polymorphisms in the development of recurrent pregnancy loss (RPL) has been studied. RPL or miscarriage is defined as the occurrence of two or more consecutive pregnancy losses before the 20th week of gestation. There are diverse causes leading to RPL, including genetic, anatomical, hormonal, and immunological factors. With regard to cytokine polymorphisms, a few of them have been found to be associated with an increased risk of RPL, for instance, variations in the genes that code for interleukin‐6, tumor necrosis factor‐alpha, and interleukin‐10. The exact mechanisms by which cytokine polymorphisms affect the risk of recurrent miscarriage are still being studied, and further research is essential to fully understand this complex condition. This brief review aims to summarize the recent literature on the association between cytokine polymorphisms and RPL.

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Interleukin-1beta -511T>C genetic variant contributes to recurrent pregnancy loss risk and peripheral natural killer cell proportion

Cited by 26 publications

References 37 publications

Association between Genetic Polymorphisms in Interleukin Genes and Recurrent Pregnancy Loss – A Systematic Review and Meta-Analysis

Association between Genetic Polymorphisms in Interleukin Genes and Recurrent Pregnancy Loss – A Systematic Review and Meta-Analysis

Recurrent Miscarriage: A Review

Association between cytokine polymorphisms and recurrent pregnancy loss: A review of current evidence

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