Interleukin-1B Polymorphisms and Gastric Cancer Risk—A Meta-analysis

Abstract

Some studies have reported that proinflammatory polymorphisms in interleukin-1B (IL-1B) and IL-1 receptor antagonist For each of the examined associations, there was significant heterogeneity among studies; P heterogeneity V 0.001 and I 2 ranged from 0.54 to 0.71. Noncardia cancers showed stronger associations with IL-1B À511 CT or TT and IL1-RN *2/*2 genotypes, but limiting the analysis to intestinal-type cancers, studies conducted in Western countries, or studies in which polymorphisms were in Hardy-Weinberg equilibrium, made no material difference in the results. The overall associations between IL-1B or IL-1RN proinflammatory polymorphisms and gastric cancer were null but several studies showed an association. The sources of this variation are unclear. (Cancer Epidemiol Biomarkers Prev 2006;15(10):1920 -8)

IL-1B −31T>C promoter polymorphism is associated with gastric stump cancer but not with early onset or conventional gastric cancers

“…Positive associations between pro-inflammatory genotypes of IL-1B −31 and higher risk of gastric cancer have been previously reported in populations from Poland, Scotland, and Mexico [8,9,12]. This is in contrast to studies in Finland [18] and Brazil [13], and our current findings are also in line with two published meta-analyses about the association of IL-1B polymorphisms with gastric cancer in a Caucasian population [3,19]. It does appear that not all Asian or white populations have demonstrated a predisposition for gastric cancer in association with pro-inflammatory IL-1 polymorphisms and in some instances, studies found that there was a positive association, but with novel markers of the IL-1B gene [1].…”

Tumour-necrosis factor-A polymorphisms and gastric cancer risk: a meta-analysis

“…The most extensively studied of these proinflammatory polymorphisms are two linked SNPs in IL-1B (À511C4T and À31T4C) and a penta-allelic variable number tandem-repeat polymorphism and allele 2 (IL-1RN*2). So far, at least three meta-analyses of the associations between these polymorphisms and gastric cancer risk have been published (Camargo et al, 2006;Kamangar et al, 2006b;Wang et al, 2007). However, to our knowledge, no systematic review has been previously published on the association between TNF-A SNPs and gastric cancer.…”

“…Indeed, because several initially promising gene -disease associations gravitated towards null over time (Ioannidis et al, 2001;Kamangar et al, 2006b), it has been suggested that journals should take a cautious approach in publishing such associations (Ioannidis, 2006). However, as shown in the results and discussed below, within the studies from western countries, the association between TNF-A À308AA genotype and gastric cancer risk seems robust to many tests, including testing for publication bias, heterogeneity, and HWE.…”

The course of gastric cancer following surgery is associated with genetic variations of the interleukin-1 receptor antagonist and interleukin-1β

“…Subsequent chronic gastritis is the most recognized etiological risk factor for non-cardia gastric cancer [3][4][5]. Although half the world's population has been infected with H. pylori, only \3 % of the infected subjects are diagnosed with gastric cancer, indicating the strong influence of the host genetic background [6,7]. The immunological response to H. pylori infection strongly involves the cytokine response of the innate immune system, and particularly interleukin 1 (IL-1) [8].…”