Interleukin-19 upregulates fibronectin and collagen I expression via the NF-κB-Smad2/3 pathway in fibroblasts of patients with chronic rhinosinusitis

Bao, Hongwei; Li, Xia; Lai, Xiaoping; Chen, Xiaohong; Li, Yue; Yao, Zhouzhou; Huang, Zizhen; Huang, Jun; Chang, Lihong; Zhang, Gehua

doi:10.1007/s00011-022-01634-7

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Function Role Of Il-20 In Live Diseases1

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2024

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Cited by 4 publications

(1 citation statement)

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“…Importantly, increased IL-20 facilitates the value-added and migration of HSCs, disrupts the balance between MMPs and TIMPs, and induces massive deposition of the ECM component. In addition, IL-20 was found to induce liver fibrosis by upregulating Col I production in rat HSCs [ 31 ]. Taken together, the current work confirms that IL-20 is a pathogenic cytokine that is upregulated during liver fibrosis [ 28 ].…”

Section: Function Role Of Il-20 In Live Diseasesmentioning

confidence: 99%

The role of interleukin-20 in liver disease: Functions, mechanisms and clinical applications

Wang,

Zhan,

et al. 2024

Heliyon

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Section: Function Role Of Il-20 In Live Diseasesmentioning

confidence: 99%

The role of interleukin-20 in liver disease: Functions, mechanisms and clinical applications

Wang,

Zhan,

et al. 2024

Heliyon

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Deciphering the Receptor-Mediated Signaling Pathways of Interleukin-19 and Interleukin-20

Shaji,

Dagamajalu,

Sanjeev

et al. 2024

Journal of Interferon & Cytokine Research

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Investigation and Characterization of the RAS/RAF/MEK/ERK Pathway and Other Signaling Pathways in Chronic Sinusitis with Nasal Polyps

Niu,

Sha,

Zhu

et al. 2024

Int Arch Allergy Immunol

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Background: The clinical outcomes of drug treatments and surgical interventions for chronic sinusitis with nasal polyps (CRSwNPs) are suboptimal, and the high recurrence rate remains a significant challenge in clinical practice. Targeted therapies such as biologics provide new perspectives and directions for treating CRSwNP. Summary: With the continuous investigation of signaling pathways, RAS/RAF/MEK/ERK signaling pathway and other signaling pathways including Hippo, JAK-STAT, Wnt, TGF-β, PI3K, Notch, and NF-κB were confirmed to play an important role in the progression of CRSwNP. Among them, the abnormality of RAS/RAF/MEK/ERK signaling pathway is accompanied by the abnormality of this apoptotic component, which may provide new research directions for targeting the components of signaling pathways to mediate apoptosis. Key Messages: Abnormalities in signaling pathways are particularly important in studying the pathogenesis and treatment of CRSwNP. Therefore, this review summarizes the ongoing investigation and characterization of RAS/RAF/MEK/ERK signaling pathway and other signaling pathways in CRSwNP, which provides constructive ideas and directions for improving the treatment of CRSwNP.

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Interleukin-19 upregulates fibronectin and collagen I expression via the NF-κB-Smad2/3 pathway in fibroblasts of patients with chronic rhinosinusitis

Cited by 4 publications

References 42 publications

The role of interleukin-20 in liver disease: Functions, mechanisms and clinical applications

The role of interleukin-20 in liver disease: Functions, mechanisms and clinical applications

Deciphering the Receptor-Mediated Signaling Pathways of Interleukin-19 and Interleukin-20

Investigation and Characterization of the RAS/RAF/MEK/ERK Pathway and Other Signaling Pathways in Chronic Sinusitis with Nasal Polyps

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