Interleukin-19 (IL-19) Induces Heme Oxygenase-1 (HO-1) Expression and Decreases Reactive Oxygen Species in Human Vascular Smooth Muscle Cells

Gabunia, Khatuna; Ellison, Stephen; Singh, Harinder; Datta, Prasun K.; Kelemen, Sheri E.; Rizzo, Victor; Autieri, Michael V.

doi:10.1074/jbc.m111.312470

Cited by 41 publications

(33 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HO-1 is the inducible isoform of heme oxygenase that catalyzes the degradation of heme into biliverdin, iron, and carbon. HO-1 has also been shown to be an oxidative stress-responsive gene that may exert important roles in cytoprotection and the resolution of inflammation to maintain tissue homeostasis (12,38). In most cell types, HO-1 is inducible by heme, radiation, cytokines, inflammatory stimuli, and oxidative and heat stress (39).…”

Section: Phenolsmentioning

confidence: 99%

See 1 more Smart Citation

Expression of Cyclooxygenase-2, Nitric Oxide Synthase 2 and Heme Oxygenase-1 mRNA Induced by Bis-Eugenol in RAW264.7 Cells and their Antioxidant Activity Determined Using the Induction Period Method

Murakami

Kawata

Fujisawa

2018

View full text Add to dashboard Cite

Abstract. Background Conclusion: Most eugenol-related compounds had proinflammatory activity at high concentrations. However, they had also anti-inflammatory activity at lower concentrations. Eugenol-related compounds may exert antioxidant and anti-inflammatory activity in LPS-stimulated RAW264.7 cells possibly by inhibiting the activation of nuclear factor-kappa B (Nf-ĸB), whereas bis-eugenol requires induction of HO-1 expression. bis-Eugenol as well as curcumin, may have anti-inflammatory and anticancer therapeutic applications.Eugenol-related compounds are known to have antioxidant, anti-inflammatory, antiviral, antifungal, antibacterial, anticancer, antidiabetic and neuroprotective properties (1-3). We have previously shown that the biphenols curcumin, biseugenol, magnolol and honokiol exert antioxidant effects and also inhibit the up-regulation of cyclooxygenase-2 (Cox-2) mRNA expression elicited by lipopolysaccharide (LPS) and Porphyromonas gingivalis fimbriae (PGF) (4, 5). We have also shown that the prooxidant activity of eugenol, isoeugenol and curcumin is inhibited by visible light irradiation and treatment with horseradish peroxidase, suggesting that these compounds elicit production of intracellular reactive oxygen species (ROS) under prooxidative conditions (6-8). Interestingly, low and physiological levels of ROS are required for normal physiological activity in cells, whereas high levels of ROS promote cytotoxicity, apoptosis, and inflammatory activity. A high level of ROS modulates a number of cell signaling pathways, and regulates the expression of multiple genes such as Cox-2 and nitric oxide synthase (Nos) 2 in vitro and in vivo 819

show abstract

Section: Phenolsmentioning

confidence: 99%

“…Biliverdin and bilirubin are potent antioxidants that attenuate oxidative stress. HO-1 has anti-inflammatory, antioxidant, and antiproliferative effects (12,13), and is induced by oxidative stress.…”

mentioning

confidence: 99%

Expression of Cyclooxygenase-2, Nitric Oxide Synthase 2 and Heme Oxygenase-1 mRNA Induced by Bis-Eugenol in RAW264.7 Cells and their Antioxidant Activity Determined Using the Induction Period Method

Murakami

Kawata

Fujisawa

2018

View full text Add to dashboard Cite

show abstract

“…Hsieh and colleagues [19], found that an alternative spliced change of IL-20 stimulated proliferation of the endothelial cells. Also, IL-19 may be used as a potential therapeutic for vascular inflammatory diseases through increased expression of heme oxygenase-1 (HO-1) and reduced reactive oxygen species in human vascular smooth muscle cells [20].…”

Section: Il-19mentioning

confidence: 99%

IL-19 and IL-20 genes polymorphisms and haplotype analysis in a vesicoureteral reflux population

2013

View full text Add to dashboard Cite

“…Rather, IL-19 decreases inflammatory mRNA transcript stability by inhibition of the mRNA stability factor HuR, which is known to recognize stability elements on the 3 UTR of inflammatory transcripts [133]. Also in VSMC, IL-19 induces expression of the cytoprotective and antiatherosclerotic protein heme oxygenase-1 [134]. Together, lymphocyte phenotype modulation, reduction in inflammatory transcript stability, and induction of HO-1 represent multiple novel anti-inflammatory, and potentially antiatherogenic mechanisms for IL-19.…”

Section: Il-19mentioning

confidence: 99%

“…However, recently, IL-19 has been shown to reduce angioplasty-induced restenosis in rats, and inflammatory gene expression in human VSMC [129,132]. IL-19 has also been shown to induce HO-1 expression and reduce ROS in human VSMC [134]. Together with its Th2-inducing properties, IL-19 may represent an attractive therapeutic modality to attenuate atherosclerosis.…”

Section: Upregulation Of Anti-inflammatory Cytokinesmentioning

confidence: 99%

Pro- and Anti-Inflammatory Cytokine Networks in Atherosclerosis

Autieri

2012

ISRN Vascular Medicine

Self Cite

View full text Add to dashboard Cite

Despite advances in prevention and treatment, atherosclerotic vascular disease continues to account for significant morbidity, mortality, and economic burden in the western world. Our current understanding of this disease presents atherosclerosis as a chronic inflammatory process involving multiple cell types in various stages of activation, apoptosis, and necrosis. These cells include monocyte/macrophage, dendritic cells, lymphocytes, endothelial cells, and vascular smooth muscle cells. Activation of these cells and their processes is initiated and sustained by a complex network of soluble factors termed cytokines. Cytokines are produced and recognized by both inflammatory and resident vascular cells, allowing crosstalk between these two systems. Cytokines also regulate the phenotype of many of these cell types. Recognizing functions of these cytokines and their effects on cells which populate atherosclerotic plaque is key to uncovering targets of therapeutic intervention. This paper will present recent studies which describe the cellular protagonists of atherosclerosis and the role they play in formation of atherosclerotic plaque. It will also describe the cytokines which have been identified as produced by and directly affecting dysfunction of these cells. Because atherosclerosis is considered an inflammatory condition, emphasis will be placed on inflammatory cytokines and their effects on atherogenesis. We will conclude with new directions in therapeutic strategies and points of emphasis for future research.

show abstract

Interleukin-19 (IL-19) Induces Heme Oxygenase-1 (HO-1) Expression and Decreases Reactive Oxygen Species in Human Vascular Smooth Muscle Cells

Cited by 41 publications

References 39 publications

Expression of Cyclooxygenase-2, Nitric Oxide Synthase 2 and Heme Oxygenase-1 mRNA Induced by Bis-Eugenol in RAW264.7 Cells and their Antioxidant Activity Determined Using the Induction Period Method

Expression of Cyclooxygenase-2, Nitric Oxide Synthase 2 and Heme Oxygenase-1 mRNA Induced by Bis-Eugenol in RAW264.7 Cells and their Antioxidant Activity Determined Using the Induction Period Method

IL-19 and IL-20 genes polymorphisms and haplotype analysis in a vesicoureteral reflux population

Pro- and Anti-Inflammatory Cytokine Networks in Atherosclerosis

Contact Info

Product

Resources

About