Interleukin-18 and interferon-γ single nucleotide polymorphisms in Egyptian patients with tuberculosis

Hassuna, Noha A.; Feky, Mohamed El; Hussein, Aliae A. R. Mohamed; Mahmoud, Magdy S.; Idriss, Naglaa K.; Abdelwahab, Sayed F.; Ibrahim, M. M.

doi:10.1371/journal.pone.0244949

Cited by 8 publications

(6 citation statements)

References 38 publications

(18 reference statements)

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“…Although studies correlating haplotypes of IFNG gene and cytokine levels and/or susceptibility to infectious disease have not yet been carried out in dog, several studies described different haplotypes in this gene as being related to the susceptibility or resistance to infectious diseases in humans, including parasitic infection diseases. For example, some authors associated IFNG haplotypes with the susceptibility to virus infection, such as hepatitis B virus [59], T-lymphotropic virus type 1 infection [60], or tuberculosis [61,62], as well as bacterial infections such as brucellosis [63], or parasitic infections such as malaria [64,65]. Related to leishmaniasis, Kalani et al [66] found several haplotypes in the IFNG gene related to susceptibility and resistance to visceral leishmaniasis in Iran.…”

Section: Discussionmentioning

confidence: 99%

Interleukin 6 and interferon gamma haplotypes are related to cytokine serum levels in dogs in an endemic Leishmania infantum region

et al. 2023

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Background The Ibizan Hound is a canine breed native to the Mediterranean region, where leishmaniasis is an endemic zoonosis. Several studies indicate a low prevalence of this disease in Ibizan Hound dogs, whereas other canine breeds present a high prevalence. However, the underlying molecular mechanisms still remain unknown. The aim of this work is to analyse the relationship between serum levels of cytokines and the genomic profiles in two canine breeds, Ibizan Hound (resistant canine breed model) and Boxer (susceptible canine breed model). Methods In this study, we analyse the haplotypes of genes encoding cytokines related to immune response of Leishmania infantum infection in twenty-four Boxers and twenty-eight Ibizan Hounds apparently healthy using CanineHD DNA Analysis BeadChip including 165,480 mapped positions. The haplo.glm extension of haplo.score was used to perform a General Linear Model (GLM) regression to estimate the magnitude of individual haplotype effects within each cytokine. Results Mean levels of interferon gamma (IFN-γ), interleukin 2 (IL-2) and IL-18 in Boxer dogs were 0.19 ± 0.05 ng/ml, 46.70 ± 4.54 ng/ml, and 36.37 ± 30.59 pg/ml, whereas Ibizan Hound dogs present 0.49 ± 0.05 ng/ml, 64.55 ± 4.54 ng/ml, and 492.10 ± 31.18 pg/ml, respectively. The GLM regression shows fifteen haplotypes with statistically significant effect on the cytokine serum levels (P < 0.05). The more relevant are IL6-CGAAG and IFNG-GCA haplotypes, which increase and decrease the IL-2, IL-8 and IFN-γ serum levels, respectively. Conclusions Haplotypes in the IFNG and IL6 genes have been correlated to serum levels of IFN-γ, IL-2 and IL-18, and a moderate effect has been found on IL8 haplotype correlated to IL-8 and IL-18 serum levels. The results indicate that the resistance to L. infantum infection could be a consequence of certain haplotypes with a high frequency in the Ibizan Hound dog breed, while susceptibility to the disease would be related to other specific haplotypes, with high frequency in Boxer. Future studies are needed to elucidate whether these differences and haplotypes are related to different phenotypes in immune response and expression gene regulation to L. infantum infections in dogs and their possible application in new treatments and vaccines. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Interleukin 6 and interferon gamma haplotypes are related to cytokine serum levels in dogs in an endemic Leishmania infantum region

et al. 2023

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“…Although studies correlating haplotypes of IFNG gene and cytokines levels and/or susceptibility to infectious disease have not yet been carried out in dog, several studies described different haplotypes in this gene to be related to the susceptibility or resistance to infectious diseases in humans, including parasitic infection diseases. For example, some authors related IFNG haplotypes with the susceptibility against virus infection as hepatitis B virus [60], T-lymphotropic virus type 1 infection [61], or tuberculosis [62,63], against bacterial infection as brucellosis [64], and against parasitic infection as malaria [65,66]. Related to leishmaniasis, Kalani et al (2019) found several haplotypes in IFNG gene related to susceptibility and resistance to visceral leishmaniasis in Iran [67].…”

Section: Discussionmentioning

confidence: 99%

Interleukin 6 and Interferon Gamma Haplotypes Are Related to Cytokine Serum Levels in Dogs in an Endemic <em>Leishmania infantum </em>Region

Álvarez¹,

Rentero-Garrido²,

Marín-García³

et al. 2022

Preprint

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Background: The Ibizan Hound is a canine breed native to the Mediterranean region, where leishmaniasis is an endemic zoonosis. Several studies indicate a low prevalence of this disease in dogs, whereas other canine breeds present a high prevalence. However, the molecular underlaying mechanisms yet remains unknown. Methods: In this study, we analyze the haplotypes of genes encode cytokines related to immune response of Leishmania infantum infection in twenty-four Boxer and twenty-four Ibizan hound apparently healthy using CanineHD DNA Analysis BeadChip including 165,480 mapped positions. Results: The results show that several haplotypes of genes encoding Interleukin 6 (IL6) and Interferon gamma (IFNG) are related to Interferon gamma (IFN-γ), and Interleukins (IL) 2 and 18 serum levels. Our results indicate that the regulation of immune response is different in the two canine breeds analyzed and are related to the haplotype compositions of the genes encoding these cytokines. Conclusions: Future studies are needed to elucidate whether these differences and haplotypes are related to different phenotypes in immune response and expression gene regulation to L. infantum infection in dogs.

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“…IL-18 gene is located on chromosome 11q22.2–q22.3 and contains numerous SNPs in the promoter region [ 114 , 115 ]. It encodes proinflammatory cytokine interleukin-18 (IL-18), which is central to the inflammatory chain reaction.…”

Section: Genes and Snps That May Be Associated With Ir And Atheroscle...mentioning

confidence: 99%

Genetic Markers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease

et al. 2023

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Type 2 diabetes mellitus (T2DM) is characterized by impaired insulin secretion on a background of insulin resistance (IR). IR and T2DM are associated with atherosclerotic coronary artery disease (CAD). The mechanisms of IR and atherosclerosis are known to share similar genetic and environmental roots. Endothelial dysfunction (ED) detected at the earliest stages of IR might be the origin of atherosclerosis progression. ED influences the secretion of pro-inflammatory cytokines and their encoding genes. The genes and their single nucleotide polymorphisms (SNPs) act as potential genetic markers of IR and atherosclerosis. This review focuses on the link between IR, T2DM, atherosclerosis, CAD, and the potential genetic markers CHI3L1, CD36, LEPR, RETN, IL-18, RBP-4, and RARRES2 genes.

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Interleukin-18 and interferon-γ single nucleotide polymorphisms in Egyptian patients with tuberculosis

Cited by 8 publications

References 38 publications

Interleukin 6 and interferon gamma haplotypes are related to cytokine serum levels in dogs in an endemic Leishmania infantum region

Interleukin 6 and interferon gamma haplotypes are related to cytokine serum levels in dogs in an endemic Leishmania infantum region

Interleukin 6 and Interferon Gamma Haplotypes Are Related to Cytokine Serum Levels in Dogs in an Endemic <em>Leishmania infantum </em>Region

Genetic Markers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease

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