Interleukin-17A promotes rheumatoid arthritis synoviocytes migration and invasion under hypoxia by increasing MMP2 and MMP9 expression through NF-κB/HIF-1α pathway

Li, Guoqing; Zhang, Yu; Qian, Yayun; Zhang, Hua; Guo, Shiyu; Sunagawa, Makoto; Hisamitsu, Tadashi; Liu, Yanqing

doi:10.1016/j.molimm.2012.08.018

Cited by 108 publications

(79 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…MMP2 and MMP9 are frequently highly expressed in various malignant tumors and appear to increase with development stages; indeed, these proteins are essential for cancer invasion and metastasis. Li et al reported that MMP2 and MMP9 upregulation promotes the migration and invasion of tumor cells (31). In this study, VEGF, MMP2 and MMP9 were upregulated by atrazine in vitro and in vivo, indicating that atrazine can promote metastasis and migration in RM1 cells.…”

Section: Discussionsupporting

confidence: 55%

Atrazine promotes RM1 prostate cancer cell proliferation by activating STAT3 signaling

Tian

et al. 2016

International Journal of Oncology

View full text Add to dashboard Cite

Atrazine, a widely used pesticide, is frequently detected in soil and surface water, which alarms epidemiologists and medical professionals because of its potential deleterious effects on health. Indeed, atrazine is a potent endocrine disruptor that increases aromatase expression in some human cancer cell lines. Both animal and human studies have suggested that atrazine is possibly carcinogenic, although discrepant results have been reported. In this study, RM1 cells were used to explore the atrazine effects on prostate cancer. Proliferation, migration and invasion of RM1 cells were assessed by colony formation, wound-healing and invasion assays, respectively, after in vitro exposure to atrazine. In addition, an RM1 cell xenograft model was generated to evaluate the effects of atrazine in vivo. To explore the molecular mechanisms, qRT‑PCR, immunohistochemistry, and western blot analyses were employed to detect mRNA and protein levels of STAT3 signaling and cell cycle related proteins, including p53, p21, cyclin B1 and cyclin D1. Interestingly, RM1 cell proliferation was increased after treatment with atrazine, concomitantly with STAT3 signaling activation. These results suggest that atrazine promotes RM1 cell growth in vitro and in vivo by activating STAT3 signaling.

show abstract

Section: Discussionsupporting

confidence: 55%

Atrazine promotes RM1 prostate cancer cell proliferation by activating STAT3 signaling

Tian

et al. 2016

International Journal of Oncology

View full text Add to dashboard Cite

show abstract

“…However, there are various other signaling pathways such as the nuclear factor-κB signaling pathway that also are important in the induction and maintenance of EMT (42). The impact that EMT plays on tumor metastasis is still controversial (43)(44)(45). To better understand the exact mechanisms of tumor metastasis and its association with EMT and IL-8, further studies are required to characterize other signaling pathways, as well as the phenotype of RCC cells, in the future.…”

Section: Discussionmentioning

confidence: 99%

IL-8 induces the epithelial-mesenchymal transition of renal cell carcinoma cells through the activation of AKT signaling

Zhou

Liu

et al. 2016

Oncology Letters

View full text Add to dashboard Cite

Abstract. The epithelial-mesenchymal transition (EMT) process has increasingly been examined due to its role in the progression of human tumors. Renal cell carcinoma (RCC) is one of the most common urological tumors that results in patient mortality. Previous studies have demonstrated that the EMT process is closely associated with the metastasis of RCC; however, the underlying molecular mechanism has not been determined yet. The present study revealed that interleukin (IL)-8 was highly expressed in metastatic RCC. IL-8 could induce the EMT of an RCC cell line by enhancing N-cadherin expression and decreasing E-cadherin expression. Furthermore, IL-8 could induce AKT phosphorylation, and the phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitor LY294002 could inhibit the EMT of RCC cells that was induced by IL-8. Therefore, these results suggest that IL-8 is able to promote the EMT of RCC through the activation of the AKT signal transduction pathway, and this may provide a possible molecular mechanism for RCC metastasis.

show abstract

“…In addition to their roles in extracellular matrix remodeling, MMPs have been found to regulate the migration of cells, including fibroblasts. MMP-2 and MMP-9, for example, have been implicated in the migration and invasion of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis (31), and LPA signaling through LPA 1 has been shown to regulate MMP expression, including that of MMP-2 (32). We consequently compared MMP expression in PSFBs isolated from the lungs of LPA 1 KO and WT mice at 3 weeks of age.…”

Section: Impaired Migration Of Lpa 1 -Deficient Psfbsmentioning

confidence: 99%

Lysophosphatidic Acid Signaling through the Lysophosphatidic Acid-1 Receptor Is Required for Alveolarization

Funke

Knudsen

Lagares³

et al. 2016

Am J Respir Cell Mol Biol

View full text Add to dashboard Cite

Lysophosphatidic acid (LPA) signaling through one of its receptors, LPA 1 , contributes to both the development and the pathological remodeling after injury of many organs. Because we found previously that LPA-LPA 1 signaling contributes to pulmonary fibrosis, here we investigated whether this pathway is also involved in lung development. Quantitative assessment of lung architecture of LPA 1 -deficient knockout (KO) and wild-type (WT) mice at 3, 12, and 24 weeks of age using design-based stereology suggested the presence of an alveolarization defect in LPA 1 KO mice at 3 weeks, which persisted as alveolar numbers increased in WT mice into adulthood. Across the ages examined, the lungs of LPA 1 KO mice exhibited decreased alveolar numbers, septal tissue volumes, and surface areas, and increased volumes of the distal airspaces. Elastic fibers, critical to the development of alveolar septa, appeared less organized and condensed and more discontinuous in KO alveoli starting at P4. Tropoelastin messenger RNA expression was decreased in KO lungs, whereas expression of matrix metalloproteinases degrading elastic fibers was either decreased or unchanged. These results are consistent with the abnormal lung phenotype of LPA 1 KO mice, being attributable to reduced alveolar septal formation during development, rather than to increased septal destruction as occurs in the emphysema of chronic obstructive pulmonary disease. Peripheral septal fibroblasts and myofibroblasts, which direct septation in late alveolarization, demonstrated reduced production of tropoelastin and matrix metalloproteinases, and diminished LPA-induced migration, when isolated from LPA 1 KO mice. Taken together, our data suggest that LPA-LPA 1 signaling is critically required for septation during alveolarization.

show abstract

Interleukin-17A promotes rheumatoid arthritis synoviocytes migration and invasion under hypoxia by increasing MMP2 and MMP9 expression through NF-κB/HIF-1α pathway

Cited by 108 publications

References 39 publications

Atrazine promotes RM1 prostate cancer cell proliferation by activating STAT3 signaling

Atrazine promotes RM1 prostate cancer cell proliferation by activating STAT3 signaling

IL-8 induces the epithelial-mesenchymal transition of renal cell carcinoma cells through the activation of AKT signaling

Lysophosphatidic Acid Signaling through the Lysophosphatidic Acid-1 Receptor Is Required for Alveolarization

Contact Info

Product

Resources

About