Interleukin-17A Promotes Human Disc Degeneration by Inhibiting Autophagy Through the Activation of the Phosphatidylinositol 3-Kinase/Akt/Bcl2 Signaling Pathway

IL‐17 in intervertebral disc degeneration: Mechanistic insights and therapeutic implications

“…There is increasing evidence that this signaling pathway is closely associated with the occurrence and development of IDD (Ouyang et al, 2017, Shao et al, 2020, W. Xu, Ding, et al, 2021. Interestingly, recent work from our laboratory showed that treatment with recombinant IL-17 aggravates IDD by inhibiting NP cell autophagy via activation of the PI3K/Akt/ Bcl-2 pathway (He et al, 2020). This reveals a novel molecular mechanism by which IL-17 promotes disc degeneration.…”

“…It has been shown that IL-17 is closely associated with inflammatory diseases, including rheumatoid arthritis (Taams, 2020), inflammatory bowel disease (Cătană et al, 2015), and asthma (Ramakrishnan et al, 2019). Of note, there is increasing evidence that IL-17 promotes the onset and development of IDD through multiple mechanisms (He et al, 2020;Risbud & Shapiro, 2014). In the current review, we summarized the current knowledge about the role of IL-17 in IDD to provide an important framework for future research and therapeutic intervention.…”

Exploring the mechanism of Buyang Huanwu decoction in the treatment of lumbar disc herniation based on network pharmacology and molecular docking

“…IL-17A promotes intervertebral disc degeneration by inhibiting autophagy through activation of the PI3K/Akt/Bcl-2 signaling pathway. [ 38 ] The MAPK pathway participates in central sensitization and nociceptive specific signaling in dorsal horn neurons. [ 39 ] This study focuses on the PI3K-Akt signaling pathway.…”

The Role of IL-17-Mediated Inflammatory Processes in the Pathogenesis of Intervertebral Disc Degeneration and Herniation: A Comprehensive Review

“…There are many reports based on the addition of IL-17A to culture NP cells showing that IL-17A affects NP cells directly in vitro ( Gabr et al, 2011 ; Lin et al, 2015 ; Wang et al, 2015 ; Hu et al, 2016 ; Li et al, 2016 ; Yao et al, 2016 ; Suyama et al, 2018 ; Liu et al, 2019 ; He et al, 2020 ). In an in vitro study, IL-17A treatment of NP cells isolated from IVD revealed that IL-17A inhibits the proliferation of cells and extracellular matrix synthesis ( Lin et al, 2015 ).…”

“…With regards to the relation between IL-17A and PI3K/AKT, He et al reported that IL-17A increases the activation levels of the PI3K/AKT pathway, which then induces the Bcl-2 expression in NP cells, and that led to the suppression of NP cells autophagy ( He et al, 2020 ). In NP tissues, it was reported that autophagy regulates the catabolic effects and apoptosis in inflammatory conditions ( Shen et al, 2011 ; Xu et al, 2015 ).…”