Interleukin-17A Plays a Pivotal Role in Chemically Induced Hepatocellular Carcinoma in Mice

Sun, Chao; Kono, Hiroshi; Furuya, Shinichi; Hara, Michio; Hirayama, Kazuyoshi; Akazawa, Yoshihiro; Nakata, Yoshihiro; Fujii, Hideki

doi:10.1007/s10620-015-3888-1

Cited by 18 publications

(15 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It plays a crucial role in the induction of proinflammatory cytokines, chemokines, metalloproteases, and other mediators of the immune system. [45][46][47][48] In addition, IL-17A also plays an important role in the progression of pulmonary diseases. Ding et al 49 reported that IL-17A can facilitate pulmonary inflammation and that it may play an important role in the process of pulmonary fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Clinical Role of Serum Interleukin-17A in the Prediction of Refractory Mycoplasma pneumoniae Pneumonia in Children

Jiu-ling¹,

Ji²,

Wang³

et al. 2020

IDR

View full text Add to dashboard Cite

Background: Mycoplasma pneumoniae pneumonia (MPP) is a common community-acquired pneumonia (CAP) in children, which may become refractory MPP (RMPP) to treatment. Objective: The purpose of this study was to evaluate the clinical utility of measuring serum interleukin (IL)-17A to predict RMPP. Patients and Methods: A retrospective clinical study at a single pediatric center included a review of the medical records of all children hospitalized for CAP between November 2015 and October 2019. The diagnosis of MPP was based on clinical presentation, chest radiography, and measurement of serum anti-Mycoplasma immunoglobulin IgM antibody titer using the microparticle agglutination method or sputum samples for Mycoplasma pneumoniae by PCR. Serum levels of IL-18 and IL-17A were determined by ELISA. Results: Of the 625 children diagnosed with CAP, there were 154 children with MPP and without underlying diseases who were divided into a non-refractory MPP (NRMPP) group (n = 109) and a RMPP group (n = 45). The RMPP group had a higher incidence of tachypnea, cyanosis, hypoxia, segmental or lobar pneumonia, pleural effusion, and a longer period of hospitalization compared with NRMPP group (all P-values < 0.05). A serum IL-17A level above 10.8 pg/mL was a predictor for RMPP: area under the curve (AUC) 0.822; standard error (SE) 0.039; 95% confidence interval (CI) 0.746-0.897; diagnostic sensitivity and specificity of 77.8% and 77.1%, respectively. An LDH level above 436.5 IU/L and an IL-18 level above 464.5 pg/mL were the second most useful markers for RMPP: AUC 0.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical Role of Serum Interleukin-17A in the Prediction of Refractory Mycoplasma pneumoniae Pneumonia in Children

Jiu-ling¹,

Ji²,

Wang³

et al. 2020

IDR

View full text Add to dashboard Cite

show abstract

“…Several investigators pointed out the pivotal role of inflammatory modulation in the progression of hepatocellular carcinomas [20]. The inflammatory cytokines including TNF- α , IL-6, and IL-1 β were overproduced in hepatic injury [21].…”

Section: Discussionmentioning

confidence: 99%

Antihepatocarcinoma Effect of Portulaca oleracea L. in Mice by PI3K/Akt/mTOR and Nrf2/HO‐1/NF‐κB Pathway

Zheng

Peng

et al. 2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

The purpose of the present study was to evaluate the pharmacological effects of Portulaca oleracea L. (Purslane) (PL) on N-nitrosodiethylamine- (NDEA-) induced hepatocellular carcinomas (HCC) and explore its potential mechanism. Mice were randomly assigned to four groups: control group, NDEA group, NDEA + Purslane (100 mg/kg) group, and NDEA + Purslane (200 mg/kg) group. The animal of each group was given NDEA (100 ppm) in drinking water. 1 h later, Purslane dissolved in PBS was intragastrically administered for continuous seven days. The results showed that Purslane reduced the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in liver and serum. Purslane also reduced the contents of interleukin-6 (IL-6), IL-1β, tumor necrosis factor-α (TNF-α), and methane dicarboxylic aldehyde (MDA) and restored the activity of superoxygen dehydrogenises (SOD) in serum. Purslane could obviously attenuate the hepatic pathological alteration. Furthermore, treatment with Purslane effectively inhibited the phosphorylations of phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), mammalian target of rapamycin (mTOR), nuclear factor-kappa B (NF-κB), and inhibitor of NF-κBα (IκBα) and upregulated the expressions of NF-E2-related factor 2 (Nrf2) and heme oxygenase- (HO-) 1. In conclusion, our research suggested that Purslane exhibited protective effects on NDEA-induced hepatocellular carcinomas by anti-inflammatory and antioxidative properties via the PI3K/Akt/mTOR and Nrf2/HO-1/NF-κB pathway.

show abstract

“…In addition, IL-17A regulates the development of stem cell features in both mouse and human pancreatic cancer models and critically contributes to tumor growth and progression (McAllister et al, 2014;Zhang et al, 2018). Intriguingly, IL-17 can also promote the expansion of liver progenitor cells to promote liver regeneration (Guillot et al, 2018); the absence of IL-17 signaling ablates tumorigenesis in a chemical-induced hepatocellular carcinoma (Sun et al, 2016), an inflammation-driven liver cancer model. This IL-17-driven cellular mechanism linking tissue repair to tumorigenesis probably also applies to colon cancer.…”

Section: Il-17-induced Mitogenic Signaling and Cancermentioning

confidence: 99%

The role of interleukin-17 in tumor development and progression

Zhao

Xing

Herjan

et al. 2019

Journal of Experimental Medicine

161

128

View full text Add to dashboard Cite

IL-17, a potent proinflammatory cytokine, has been shown to intimately contribute to the formation, growth, and metastasis of a wide range of malignancies. Recent studies implicate IL-17 as a link among inflammation, wound healing, and cancer. While IL-17–mediated production of inflammatory mediators mobilizes immune-suppressive and angiogenic myeloid cells, emerging studies reveal that IL-17 can directly act on tissue stem cells to promote tissue repair and tumorigenesis. Here, we review the pleotropic impacts of IL-17 on cancer biology, focusing how IL-17–mediated inflammatory response and mitogenic signaling are exploited to equip its cancer-promoting function and discussing the implications in therapies.

show abstract

Interleukin-17A Plays a Pivotal Role in Chemically Induced Hepatocellular Carcinoma in Mice

Abstract: These results demonstrated that IL-17A plays a pivotal role in chemically induced hepatic carcinogenesis, which is most likely through inflammation-initiated oxidative DNA damage and cell proliferation.

Cited by 18 publications

References 42 publications

<p>Clinical Role of Serum Interleukin-17A in the Prediction of Refractory <em>Mycoplasma pneumoniae</em> Pneumonia in Children</p>

<p>Clinical Role of Serum Interleukin-17A in the Prediction of Refractory <em>Mycoplasma pneumoniae</em> Pneumonia in Children</p>

Antihepatocarcinoma Effect of Portulaca oleracea L. in Mice by PI3K/Akt/mTOR and Nrf2/HO‐1/NF‐κB Pathway

The role of interleukin-17 in tumor development and progression

Contact Info

Product

Resources

About