Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis

Couderc, Elodie; Morel, Franck; Levillain, P.; Buffiere-Morgado, Amandine; Camus, Magalie; Paquier, C.; Bodet, Charles; Jégou, Jean‐François; Pohin, Mathilde; Favot, Laure; Garcia, Martine; Huguier, V.; Mcheik, Jiad N.; Lacombe, Christian; Yssel, Hans; Guillet, G.; Bernard, François‐Xavier; Lecron, Jean‐Claude

doi:10.1371/journal.pone.0181486

Cited by 22 publications

(18 citation statements)

References 47 publications

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“…Activated cells produce a vast number of pro-inflammatory cyto-and chemokines (such as interleukins, interferons -INF, etc.). The connection between psoriasis and at least IL-4, 17, 23 has been established [44,45,46]. Those are also a grip point for modern, biological treatment options, which inhibit the exaggerated immune reaction which is usually not present without a triggering factor.…”

Section: State Of Knowledgementioning

confidence: 99%

Environmental risk factors and epigenetic alternations in psoriasis

Roszkiewicz¹,

Dopytalska²,

Szymańska³

et al. 2020

Ann Agric Environ Med.

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Introduction and objective. Psoriasis isa quite common, chronic and immune-mediated skin disorder. The prevalence of psoriasis differs in various countries, but it is said to affect 2% of the world's population in general. Psoriasis has many different clinical features but all lesions have the same characteristic: erythema, thickening and scale, although other clinical features are also connected, such as psoriatic arthritis, obesity and metabolic syndrome. All of these may lead to conditions impairing the quality of life. This review is an attempt to summarize recent data regarding environmental factors, together with epigenetic markers and processes playing an important role in psoriasis. State of knowledge. Many different environmental factors play a role in genetically predisposed patients. This is causes epigenetic alternations which may be a linking part in the whole process. Many studies have indicated a connection between psoriasis and various genes and antigens. The presence of HLA-Cw6 is common as well a strong link between its presence and the onset of psoriasis being observed. The main alternations are DNA methylation, histone's modifications and the role of microRNA. Excessive reaction is usually not present without a triggering factor. Environmental factors are mostly rated, such as drugs, life style and habits (smoking, alcohol), diet, physical trauma (skin injury provoking Koebner phenomenon), stress, microorganism and infections. Conclusions. The correlation between pathogenesis of psoriasis and environmental risk factors, together with epigenetic alternations still require more investigation. Education about diet habits, nutrition, weight loss and healthy lifestyle seems to be important during the treatment of psoriasis.

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Section: State Of Knowledgementioning

confidence: 99%

Environmental risk factors and epigenetic alternations in psoriasis

Roszkiewicz¹,

Dopytalska²,

Szymańska³

et al. 2020

Ann Agric Environ Med.

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“…SAA is a major serum acute-phase protein which impacts 1% of patients with chronic inflammation such as rheumatoid arthritis and neoplastic diseases [ 14 ]. It is mainly produced in the liver but extra-hepatic synthesis involving the skin and adipose tissue has been reported [ 15 ]. In the clinical field, SAA is an important biomarker for inflammatory diseases [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…It is mainly produced in the liver but extra-hepatic synthesis involving the skin and adipose tissue has been reported [ 15 ]. In the clinical field, SAA is an important biomarker for inflammatory diseases [ 15 , 16 , 17 ]. The N-terminal of SAA is the most hydrophobic and amyloidogenic segment of the protein sequence and a driver of AA amyloidosis.…”

Section: Introductionmentioning

confidence: 99%

Dietary Intake of Rosmarinic Acid Increases Serum Inhibitory Activity in Amyloid A Aggregation and Suppresses Deposition in the Organs of Mice

Lin

Watanabe

Kuragano

et al. 2020

IJMS

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Serum amyloid A (SAA) is one of the most important precursor amyloid proteins and plays a vital step in AA amyloidosis, although the underlying aggregation mechanism has not been elucidated. Since SAA aggregation is a key step in this pathogenesis, inhibitors are useful to prevent and treat AA amyloidosis, serving as tools to investigate the pathogenic mechanism. In this study, we showed that rosmarinic acid (RA), which is a well-known inhibitor of the aggregation of amyloid β (Aβ), displayed inhibitory activity against SAA aggregation in vitro using a microliter-scale high-throughput screening (MSHTS) system with quantum-dot nanoprobes. Therefore, we evaluated the amyloid aggregation inhibitory activity of blood and the deposition of SAA in organs by feeding mice with Melissa officinalis extract (ME) containing RA as an active substance. Interestingly, the inhibitory activity of ME-fed mice sera for SAA and Aβ aggregation, measured with the MSHTS system, was higher than that of the control group. The amount of amyloid deposition in the organs of ME-fed mice was lower than that in the control group, suggesting that the SAA aggregation inhibitory activity of serum is associated with SAA deposition. These results suggest that dietary intake of RA-containing ME enhanced amyloid aggregation inhibitory activity of blood and suppressed SAA deposition in organs. This study also demonstrated that the MSHTS system could be applied to in vitro screening and to monitor comprehensive activity of metabolized foods adsorbed by blood.

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“…Moreover, pathogenic Th17-secreted IL-17 induces proliferation of keratinocytes and secretion of antimicrobial peptides, cytokines, and chemokines, which in turn recruit more immune cells to inflamed tissue. This positive feedback loop between Th17 cells and keratinocytes has been proved to contribute to the chronic inflammatory phase of psoriasis ( 43 , 49 , 50 ). Other proinflammatory factors released by pathogenic Th17 cells, such as IL-22, TNF-α, and granulocyte-macrophage colony-stimulating factor (GM-CSF), stimulate keratinocytes to release chemokines, further sustaining the inflammatory cycle to promote the development of psoriasis ( 51 , 52 ).…”

Section: The Main Role Of Pathogenic Th17 Cells In Psoriasismentioning

confidence: 98%

“…In addition, IL-23, which is produced by activated mDCs, drives naïve T cells to develop into pathogenic Th17 cells ( 42 ). IL-17, which is predominantly produced by pathogenic Th17 ( 43 ), is significantly elevated in patients with psoriasis compared with healthy subjects. Upregulated IL-17 has potent ability to recruit neutrophils ( 44 , 45 ), to activate T cells, to stimulate fibroblasts ( 46 ), and to promote development of multiple lineages of macrophages ( 47 , 48 ).…”

Section: The Main Role Of Pathogenic Th17 Cells In Psoriasismentioning

confidence: 99%

Transcription Factor Retinoid-Related Orphan Receptor γt: A Promising Target for the Treatment of Psoriasis

et al. 2018

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Psoriasis, which is a common chronic inflammatory skin disease, endangers human health and brings about a major economic burden worldwide. To date, treatments for psoriasis remain unsatisfied because of their clinical limitations and various side effects. Thus, developing a safer and more effective therapy for psoriasis is compelling. Previous studies have explicitly shown that psoriasis is an autoimmune disease that is predominantly mediated by T helper 17 (Th17) cells, which express high levels of interleukin-17 (IL-17) in response to interleukin-23 (IL-23). The discovery of the IL-23–Th17–IL-17 axis in the development of psoriasis has led to the paradigm shift of understanding pathogenesis of psoriasis. Although anti-IL-17 antibodies show marked clinical efficacy in treating psoriasis, compared with antibodies targeting IL-17A or IL-17R alone, targeting Th17 cells themselves may have a maximal benefit by affecting multiple proinflammatory cytokines, including IL-17A, IL-17F, IL-22, and granulocyte-macrophage colony-stimulating factor, which likely act synergistically to drive skin inflammation in psoriasis. In this review, we mainly focus on the critical role of Th17 cells in the pathogenesis of psoriasis. Especially, we explore the small molecules that target retinoid-related orphan receptor γt (RORγt), a vital transcription factor for Th17 cells. Given that RORγt is the lineage-defining transcription factor for Th17 cell differentiation, targeting RORγt via small molecular inverse agonists may be a promising strategy for the treatment of Th17-mediated psoriasis.

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Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis

Cited by 22 publications

References 47 publications

Environmental risk factors and epigenetic alternations in psoriasis

Environmental risk factors and epigenetic alternations in psoriasis

Dietary Intake of Rosmarinic Acid Increases Serum Inhibitory Activity in Amyloid A Aggregation and Suppresses Deposition in the Organs of Mice

Transcription Factor Retinoid-Related Orphan Receptor γt: A Promising Target for the Treatment of Psoriasis

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