Interleukin‐17‐producing cell infiltration in the breast cancer tumour microenvironment is a poor prognostic factor

Chen, Wen Chung; Lai, Yi-Chun; Chen, Hung Yu; Guo, How‐Ran; Su, Ih Jen; Chen, Helen H.W.

doi:10.1111/his.12156

Cited by 120 publications

(128 citation statements)

References 44 publications

(50 reference statements)

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“…Tumor infiltration by IL-17-producing cells has been proposed to be a negative prognostic factor, 19 suggesting that Th17 cells may be detrimental in this context. However, the underlying biological mechanisms have not yet been reported.…”

Section: Discussionmentioning

confidence: 99%

Human ectonucleotidase-expressing CD25^highTh17 cells accumulate in breast cancer tumors and exert immunosuppressive functions

Thibaudin¹,

Chaix²,

Boidot³

et al. 2015

OncoImmunology

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Section: Discussionmentioning

confidence: 99%

Human ectonucleotidase-expressing CD25^highTh17 cells accumulate in breast cancer tumors and exert immunosuppressive functions

Thibaudin¹,

Chaix²,

Boidot³

et al. 2015

OncoImmunology

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“…tumors, these cells are indicative of a poor prognosis for the patient (9,11,12). TGF-α is secreted by various types of cells and stimulates their proliferation, differentiation and development (10).…”

Section: Association Of Serum Interleukin-10 Interleukin-17amentioning

confidence: 99%

Association of serum interleukin‑10, interleukin‑17A and transforming growth factor‑α levels with human benign and malignant breast diseases

Liu

Shen

et al. 2018

Exp Ther Med

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Abstract. Interleukin-10 (IL-10), interleukin-17A (IL-17A) and transforming growth factor α (TGF-α) have been implicated in the progression of breast cancer. However, the diagnostic and prognostic roles of these cytokines in ductal carcinoma remain unclear. The present study therefore aimed to determine the serum levels of IL-10, IL-17 and TGF-α in subjects with benign and malignant breast diseases and to evaluate the clinical significance of these cytokines in ductal carcinoma. Pre-operative serum samples were collected from 378 patients with breast disease and 70 healthy subjects. IL-10, IL-17A and TGF-α levels were measured using ELISA. Serum levels of these cytokine in patients with different breast diseases were evaluated. Furthermore, correlations between levels of these cytokines and the expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) in ductal carcinoma were determined. The results demonstrated that serum levels of IL-10 and IL-17A were significantly increased in subjects with atypical hyperplasia and ductal carcinoma. Furthermore, IL-10 and IL-17A levels were increased in patients with a more serious clinical tumor stage and tumors that were ER -and PR -. Furthermore, high serum levels of TGF-α were associated with HER2 + tumors. A strong positive correlation was identified between TGF-α and IL-17A levels. Therefore, the results of the current study revealed that elevated serum IL-10, IL-17A and TGF-α levels are strongly associated with ductal carcinoma, specifically with tumor stage. High serum levels of IL-10 and IL-17A were also associated with the negative expression of ER and PR in ductal carcinoma, and high serum levels of TGF-α were associated with the positive expression of HER2 in ductal carcinoma. Thus, serum cytokine levels may be measured to identify patients with a poor prognosis who may benefit from more aggressive management and treatment.

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“…29 Another study reported that post-chemotherapy samples were used when no pretreatment samples were available for immunohistochemistry. 30 A final potential risk factor was observed in a study of leukemia patients treated with allogeneic stem cell transplantation after myeloablative conditioning, which included donors that varied from related to unrelated and different prophylaxis regimens to prevent graft-vs.-host disease. 31 Additional study details and concerns are listed per sample type in Tables S1-4.…”

Section: Study Design and Selection Criteriamentioning

confidence: 99%

The correlations between IL-17 vs. Th17 cells and cancer patient survival: a systematic review

et al. 2015

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Both IL-17 and Th17 cells have been ascribed tumor promoting as well as tumor suppressing functions. We reviewed the literature on correlations between IL-17 versus Th17 cells and survival in human cancer, following the PRISMA guidelines. Serum, formalin-fixed, paraffin-embedded (FFPE) tissue and peripheral blood samples were most frequently studied. High IL-17 quantities were correlated with poor prognosis, whereas high Th17 cell frequencies were correlated with improved prognosis. Since Th17 cells are a subpopulation of IL-17 cells and had a different correlation with prognosis than total IL-17, we substantiate that a distinction should be made between Th17 and other IL-17 cells.

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Interleukin‐17‐producing cell infiltration in the breast cancer tumour microenvironment is a poor prognostic factor

Abstract: Our results indicate that a high level of IL-17-producing cells in the breast cancer tumour microenvironment is a poor prognostic factor.

Cited by 120 publications

References 44 publications

Human ectonucleotidase-expressing CD25^highTh17 cells accumulate in breast cancer tumors and exert immunosuppressive functions

Human ectonucleotidase-expressing CD25^highTh17 cells accumulate in breast cancer tumors and exert immunosuppressive functions

Association of serum interleukin‑10, interleukin‑17A and transforming growth factor‑α levels with human benign and malignant breast diseases

The correlations between IL-17 vs. Th17 cells and cancer patient survival: a systematic review

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Interleukin‐17‐producing cell infiltration in the breast cancer tumour microenvironment is a poor prognostic factor

Abstract: Our results indicate that a high level of IL-17-producing cells in the breast cancer tumour microenvironment is a poor prognostic factor.

Cited by 120 publications

References 44 publications

Human ectonucleotidase-expressing CD25highTh17 cells accumulate in breast cancer tumors and exert immunosuppressive functions

Human ectonucleotidase-expressing CD25highTh17 cells accumulate in breast cancer tumors and exert immunosuppressive functions

Association of serum interleukin‑10, interleukin‑17A and transforming growth factor‑α levels with human benign and malignant breast diseases

The correlations between IL-17 vs. Th17 cells and cancer patient survival: a systematic review

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Human ectonucleotidase-expressing CD25^highTh17 cells accumulate in breast cancer tumors and exert immunosuppressive functions

Human ectonucleotidase-expressing CD25^highTh17 cells accumulate in breast cancer tumors and exert immunosuppressive functions