Interleukin-17 in inflammatory skin disorders

Beelen, Astrid J. van; Teunissen, Marcel B. M.; Kapsenberg, Martien L.; Jong, Esther C. de

doi:10.1097/aci.0b013e3282ef869e

Cited by 160 publications

(126 citation statements)

References 74 publications

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“…Conversely, pathogenic Th17 responses are linked with the onset of chronic inflammatory and autoimmune diseases including contact hypersensitivity and psoriasis vulgaris (5,6,24). Accordingly, human Th17 cells express CCR6 and CCR4, two chemokine receptors responsible for directional migration and skin homing of effector immune cells (44,45).…”

Section: Discussionmentioning

confidence: 99%

“…The immunogenicity of skin correlates with a substantial number of resident DCs including epidermal Langerhans cells (LCs) and dermal DCs (DDCs), which are both capable of activating naive T cells and biasing Th1 and Th2 immune responses (2,21,22). In addition, effector Th17 and Th1 cells infiltrate the skin during the development of chronic cutaneous inflammatory and autoimmune disorders, such as those observed in psoriatic plaques, indicating that skin resident DCs have a role in the initiation and maintenance of Th17 immunity (6,23,24). Nevertheless, the capacity of different populations of human cutaneous DCs to initiate or inhibit Th17 differentiation has not been addressed mainly due to the lack of appropriate experimental models necessary to obtain a sufficient number of highly purified human LCs and DDCs.…”

Section: Fficient Activation Of Naive Cd4mentioning

confidence: 99%

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Differential Capability of Human Cutaneous Dendritic Cell Subsets to Initiate Th17 Responses

Mathers¹,

Janelsins²,

Rubin³

et al. 2009

The Journal of Immunology

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Human skin-migratory dendritic cells (DCs) have the ability to prime and bias Th1 and Th2 CD4+ T lymphocytes. However, whether human cutaneous DCs are capable of initiating proinflammatory Th17 responses remains undetermined. We report that skin-migratory DCs stimulate allogeneic naive CD4+ T cells that differentiate simultaneously into two distinct effector Th17 and Th1 populations capable of homing to the skin, where they induce severe cutaneous damage. Skin-migratory Langerhans cells (smiLCs) were the main cutaneous DC subset capable of inducing Th17 responses dependent on the combined effects of IL-15 and stabilized IL-6, which resulted in IL-6 trans-signaling of naive CD4+ T cells. Different from smiLCs, purified skin-migratory dermal DCs did not synthesize IL-15 and were unable to bias Th17 responses. Nevertheless, these dermal DCs were capable of differentiating Th17 cells in mixed leukocyte cultures supplemented with IL-15 and stabilized IL-6. Overall, our data demonstrate that human epidermal smiLCs induce Th17 responses by mechanisms different from those previously described and highlight the need to target clinical treatments based on these variations.

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Section: Discussionmentioning

confidence: 99%

Section: Fficient Activation Of Naive Cd4mentioning

confidence: 99%

Differential Capability of Human Cutaneous Dendritic Cell Subsets to Initiate Th17 Responses

Mathers¹,

Janelsins²,

Rubin³

et al. 2009

The Journal of Immunology

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“…33 Th17 cells are attracted into skin in pathological skin diseases such as contact dermatitis, psoriasis and atopic dermatitis 34 via C-type lectin domain family 2A that is expressed in the skin. 35 It has been reported that gut-resident Th17 cells express CD161.…”

Section: Discussionmentioning

confidence: 99%

Decidual stromal cells recruit Th17 cells into decidua to promote proliferation and invasion of human trophoblast cells by secreting IL-17

Jin

et al. 2014

Cell Mol Immunol

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T helper 17 (Th17) cells have both regulatory and protective roles in physiological conditions. The Th17 subset and the cytokine interleukin-17A (IL-17A) have been implicated in the pathogenesis of certain autoimmune diseases, several types of cancer and allograft rejection. However, the role of Th17 cells at the maternal/fetal interface remains unknown. Here, we demonstrate that Th17 cells are present in decidua and are increased in the peripheral blood of 10 clinically normal pregnancies based on intracellular cytokine analysis. Our results suggest a potential role of Th17 cells in sustaining pregnancy in humans. Furthermore, we demonstrate that decidual stromal cells (DSCs) but not trophoblast cells recruit peripheral Th17 cells into the decidua by secreting CCL2. The recruited Th17 cells promote proliferation and invasion and inhibit the apoptosis of human trophoblast cells by secreting IL-17 during the first trimester of pregnancy. These findings indicate a novel role for Th17 cells in controlling the maternal-fetal relationship and placenta development.

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“…els, IL-23 but not IL-12 is critically linked to autoimmunity (6,24,25). Based on these data, a determinant role for Th17 cells has been proposed even in the pathogenesis of human autoimmune diseases equivalent to the aforementioned murine models, such as multiple sclerosis, rheumatoid arthritis and IBD, but also psoriasis and contact dermatitis (26,27). Moreover, the role of Th1 cells, which had been previously shown to be involved in the pathogenesis of the same disorders (3), was underevaluated or even considered as protective against the Th17-mediated inflammation (28).…”

Section: The Discovery Of Th17 Cells In Mice and Humansmentioning

confidence: 99%

Th17 cells: new players in asthma pathogenesis

Cosmi

Liotta

Maggi

et al. 2011

Allergy

281

198

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CD4+ T effector lymphocytes are distinguished in different subsets on the basis of their patterns of cytokine secretion. Th1 cells, thank to IFN-c production, are responsible for cell-mediated immunity against intracellular pathogens, Th2 cells, through the production of IL-4, provide some degree of protection against helminthes, and Th17 cells, via IL-17, promote neutrophils recruitment for the clearance of bacteria and fungi. However, beyond their protective role, these T-helper subsets can also be involved in the pathogenesis of several inflammatory diseases. Asthma is an inflammatory disease characterized by different clinical phenotypes. Allergic asthma is the result of an inflammatory process driven by allergen-specific Th2 lymphocytes, whereas Th17 cells are mainly involved in those forms of asthma, where neutrophils more than eosinophils, contribute to the inflammation. The identification in allergic asthma of Th17/Th2 cells, able to produce both IL-4 and IL-17, is in keeping with the observation that different clinical phenotypes can coexist in the same patient. In conclusion, a picture in which different T-cell subpopulations are active in different phase of bronchial asthma is emerging, and the wide spectrum of clinical phenotypes is probably the expression of different cellular characters playing a role in lung inflammation.

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Interleukin-17 in inflammatory skin disorders

Cited by 160 publications

References 74 publications

Differential Capability of Human Cutaneous Dendritic Cell Subsets to Initiate Th17 Responses

Differential Capability of Human Cutaneous Dendritic Cell Subsets to Initiate Th17 Responses

Decidual stromal cells recruit Th17 cells into decidua to promote proliferation and invasion of human trophoblast cells by secreting IL-17

Th17 cells: new players in asthma pathogenesis

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