Interleukin-17 and innate immunity in infections and chronic inflammation

New Possibilities of Pharmacotherapy for Immunoinflammatory Rheumatic Diseases: A Focus on Inhibitors of Interleukin-17

“…Основная физиоло-гическая функция Th17-клеток и ИЛ17 -иммунная за-щита организма от внеклеточных бактериальных и гриб-ковых инфекций, проникающих в организм человека че-рез эпителиальный и слизистый барьеры [16]. Примером важной роли ИЛ17 в противоинфекционном иммунитете является гипер-IgE-синдром (связан с генетической му-тацией гена STAT3), при котором увеличение чувстви-тельности к инфекции Staphylococcus aureus и Candida albicans тесно связанно с дефектом Th17-клеток.…”

Rethinking of Small Molecules in Treating Psoriasis

“…IL-17 produced by Th17 cells and others, plays an important role in the regulation of the adaptive and innate immune systems as well as the pathogenesis of psoriasis. IL-17 has been associated with neutrophil recruitment, induction of a Th2 response, stimulation of macrophages to produce IL-1β and TNF-α, and induction of inflammatory mediators such as matrix metalloproteinases (MMPs) [10]. On the other hand, IL-23, with the help of IL-6 and transforming growth factor (TGF)-β, stimulates the differentiation of T cells to Th17 cells and plays an integral role in the survival of these cells, which consequently leads to an increase in the release of IL-17 [7].…”

The role of human CD1c+ DCs at activating innate and adaptive immune responses

“…IL-23 triggers the downstream production of IL-17A and IL-17F, which further induce expression of chemokine ligands including CXCL1, CXCL2 and CXCL5; promoting neutrophil and monocyte chemotaxis. Furthermore, IL-17A and IL-17F trigger the NF-κB pathway, which enhances the production of inflammatory cytokines such as TNF-α (Isailovic et al, 2015). Excessive levels of these cytokines along with activation of numerous cell types may be a mechanism of potentiating autoimmune pathology.…”

“…Furthermore, engagement of IL-17 with its receptor triggers NFκB and MAPK pathways, leading to induction of IL-1β, IL-6 and TNF-α. The most prominent function of IL-17 is promoting 36 | P a g e neutrophil chemotaxis, which is necessary for pathogen clearance at the site of infection (Isailovic et al, 2015, Ye et al, 2001b. In addition, IL-17 can trigger the production of GM-CSF, antimicrobial peptides and defensins as well as maintain epithelial integrity (Isailovic et al, 2015, Ye et al, 2001a.…”

“…The most prominent function of IL-17 is promoting 36 | P a g e neutrophil chemotaxis, which is necessary for pathogen clearance at the site of infection (Isailovic et al, 2015, Ye et al, 2001b. In addition, IL-17 can trigger the production of GM-CSF, antimicrobial peptides and defensins as well as maintain epithelial integrity (Isailovic et al, 2015, Ye et al, 2001a. In support of this, several studies have demonstrated that IL-17A play a protective role in a mouse model of colitis (O'Connor et al, 2009, Ogawa et al, 2004, Yang et al, 2008b.…”