Interleukin-13 Effectively Down-regulates the Monocyte Inflammatory Potential During Traumatic Stress

Kim, Caroline; Schinkel, Christian; Fuchs, Dietmar; Stadler, J; Walz, Alfred; Zedler, Siegfried; Donnersmarck, G. Henckel von; Faist, Eugen

doi:10.1001/archsurg.1995.01430120084013

Cited by 23 publications

(10 citation statements)

References 41 publications

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“…An increase in the serum neopterin level has also been found in patients suffering burns, hyperthermia, and hypothermia, suggesting immune activation [42,43]. In addition, a persistently high neopterin level is associated with a critical event in the development of sepsis following severe burns [44][45][46].…”

Section: Discussionmentioning

confidence: 98%

Comparative evaluation of postmortem serum concentrations of neopterin and C-reactive protein

Ishikawa

Hamel

Zhu

et al. 2008

Forensic Science International

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Section: Discussionmentioning

confidence: 98%

Comparative evaluation of postmortem serum concentrations of neopterin and C-reactive protein

Ishikawa

Hamel

Zhu

et al. 2008

Forensic Science International

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“…69 IL-13 been found to downregulate the monocyte inflammatory potential during traumatic stress. 70 Interleukin-14 (IL-14), a high molecular weight B-cell growth factor secreted by T cells and some malignant B cells was shown to induce B-cell proliferation, inhibit immunoglobulin secretion, and selectively expand some Bcell subpopulations. 71 ' 72 Although little is known about the physiologic role of this cytokine, the presence of IL-14 has been detected in patients diagnosed with B-cell type non-Hodgkin's lymphoma.…”

Section: Basic Sciencementioning

confidence: 99%

Cytokine Function:A Study in Biologic Diversity

1996

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Cytokines are a group of hormone-like polypeptide mediators that play a variety of regulatory roles in both host defense and normal and abnormal homeostatic mechanisms. They may be produced by diverse cell types and exert their function on a variety of cells. Their effects (which may be suppressive or enhancing) are on cellular proliferation, differentiation, activation, and motility. In addition, cyokines can exert cytodestructive effects on infectious agents or tumor cells, either directly or by activating cells with cytodestructive potential. Any given cytokine may have many different biologic effects. However, two different cytokines may have similar or identical activities. Cytokines may be classified on the basis of their cell of origin, their spectrum of activity, the category of activity they influence, the cells that are their targets, or on specific features of their ligand-receptor interaction. The mode of action of many of the cytokines involves typical signal transduction eventsCytokines are usually thought of as potent mediators of inflammatory and immune responses, but they also mediate a variety of nonimmunologic phenomena. They are small molecular weight proteins and glycoproteins, which act at extremely low concentrations (picomolar and femtomolar levels) by binding to receptors in a hormone-like fashion. A cytokine may act in an autocrine fashion by binding to receptors on the membrane of the cell that secreted it. It may behave in a paracrine fashion by binding to receptors on a cell in the vicinity of the cell(s) that produced it; or it may act in an endocrine fashion by binding to receptors on cells that are at a distance. Cytokines control the intensity and length of the immune response by affecting the activation, proliferation, and differentiation of various cells or by regulating antibody production or the secretion of other cytokines. 1The early studies of these soluble substances involved the description of numerous soluble factors that were described on the basis of bioassays. These factors were called lymphokines when they were the product of lym- such as protein phosphorylation, and to date there is only limited understanding of the mechanisms that lead to one activity over another when a specific cytokine is involved in a specific biologic reaction. Nevertheless, elucidation of their role in other pathologic processes has provided insight into autoimmune and allergic diseases, as well as a variety of systemic disorders. Because of their broad spectrum of activity, cytokines have been used in a variety of therapeutic settings involving both infectious diseases and neoplasia. As the number of known cytokines continues to grow, it will be increasingly difficult for the non-"cytokinologist" to follow the exponentially expanding literature. Hopefully, this brief review will provide an overview that can serve as a framework for the understanding of this important area of biology and pathology.

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“…Auch wurde hier eine signifikante Korrelation zwischen IL-6-Spiegeln und ISS beobachtet [34]. Weiterhin zeigte eine In-vitro-Studie ju È ngeren Datums das starke immunmodulatorische Potential von IL-13 auf die hier beobachtete signifikant gesteigerte Produktion von TNF-a, IL-1b, IL-6 und IL-8 durch zirkulierende Monocyten von Traumapatienten [23]. Im Plasma von Patienten nach Reanimation konnte ein rascher Anstieg von IL-6-und IL-8-Spiegeln innerhalb von 12 Std nach dem Trauma beobachtet werden, die fu È r mehr als 5 Tage signifikant erho È ht blieben, wenn der Traumascore (ISS) u È ber 25 lag [22].…”

Section: Bisherige Ergebnisse Der Klinischen Traumaforschungunclassified

Immunologie bei Schwerverletzten

Faist

Wichmann

1997

Chirurg

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Immunological complications frequently occur during the clinical course in patients with multiple injuries. The increased release of pro-inflammatory mediators during the immunological response to trauma may lead to the systemic inflammatory response syndrome (SIRS) and furthermore, to multisystem organ failure (MOF), which is associated with a mortality of up to 80%. The development of multiple organ failure following major trauma is associated with remote organ failure, the dysfunction of organs which were not initially affected by the trauma. This manuscript reviews recent data in experimental trauma research and offers a more detailed evaluation of the immunological findings in trauma patients. In particular, the role of pro- and anti-inflammatory cytokines in the development or SIRS, MOF and ROF is discussed. Despite the enormous progress in clinical immunology and the available data on trauma-induced immune dysfunction, a large number of questions still remain to be answered before the immunological alterations following severe trauma can be beneficially influenced by immunomodulatory therapeutic efforts.

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Interleukin-13 Effectively Down-regulates the Monocyte Inflammatory Potential During Traumatic Stress

Abstract: From this study and preexisting findings, we conclude that, based on its biologic properties, IL-13 should be tested as a biologic response modifier for acute states of trauma-induced host defense deficiency.

Cited by 23 publications

References 41 publications

Comparative evaluation of postmortem serum concentrations of neopterin and C-reactive protein

Comparative evaluation of postmortem serum concentrations of neopterin and C-reactive protein

Cytokine Function:A Study in Biologic Diversity

Immunologie bei Schwerverletzten

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