Interleukin-13 but Not Interleukin-4 Prolongs Eosinophil Survival and Induces Eosinophil Chemotaxis.

Horie, Shiro; Okubo, Yoshio; Hossain, Mahboob; Sato, Etsuro; Nomura, Hiroshi; Koyama, Sekiya; Suzuki, Jun; Isobe, Mitsuaki; Sekiguchi, M

doi:10.2169/internalmedicine.36.179

Cited by 113 publications

(86 citation statements)

References 29 publications

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“…Changes in eosinophil trafficking, causing eosinophilia, involve three interacting components; upregulation of chemokine production by cytokines, eosinophil activation by chemokines and eosinophil adhesion (Blanchard & Rothenberg, 2009). Some of the cytokines involved in inflammatory mechanisms are IL4, IL5 and IL13, and these proteins are mainly synthesized by Th2 lymphocytes (Moser et al, 1992;Horie et al, 1997). Among the chemokines involved in eosinophil recruitment to inflammatory sites are the CXC-chemokines, RANTES, eotaxins and macrophage chemotactic proteins (MCPs; Rothenberg & Hogan, 2005).…”

Section: Discussionmentioning

confidence: 99%

Hydroxycarbamide reduces eosinophil adhesion and degranulation in sickle cell anaemia patients

et al. 2013

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SummaryInflammation, leucocyte and red cell adhesion to the endothelium contribute to the pathogenesis of sickle cell anaemia. Neutrophils appear to be important for vaso-occlusion, however, eosinophils may also participate in this phenomenon. The role of eosinophils in the pathophysiology of sickle cell anaemia (SCA) and the effect of hydroxycarbamide (HC) therapy on the functional properties of these cells are not understood. Patients with SCA and those on HC therapy (SCAHC) were included in the study. SCAHC individuals presented significantly lower absolute numbers of eosinophils than SCA. Furthermore, SCAHC eosinophils demonstrated significantly lower adhesive properties, compared to SCA eosinophils. SCA and SCAHC eosinophils presented greater spontaneous migration when compared with control eosinophils. Baseline eosinophil peroxidase and reactive oxygen species release was higher for SCA individuals than for control individuals, as were plasma levels of eosinophil derived neurotoxin. SCAHC eosinophil degranulation was lower than that of SCA eosinophil degranulation. Eotaxin-1 and RANTES levels were higher in the plasma of SCA and SCAHC individuals, when compared with controls. These data suggest that eosinophils exist in an activated state in SCA and indicate that these cells play a role in the vaso-occlusive process. The exact mechanism by which HC may alter SCA eosinophil properties is not clear.

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Section: Discussionmentioning

confidence: 99%

Hydroxycarbamide reduces eosinophil adhesion and degranulation in sickle cell anaemia patients

et al. 2013

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“…Murine studies have revealed that IL-5 promotes the maturation of eosinophils from bone marrow precursors (21), induces the recruitment of eosinophils (22), and promotes the survival of eosinophils (21,22). In addition to the known roles for IL-5, studies have demonstrated that IL-13 is a chemoattractant for and prolongs the survival of human eosinophils (23). Recent murine studies have suggested that IL-13 may also play an important role in RSV-induced pulmonary injury (24 -28).…”

Section: R Espiratory Syncytial Virus (Rsv)mentioning

confidence: 99%

IL-13 Is Required for Eosinophil Entry into the Lung during Respiratory Syncytial Virus Vaccine-Enhanced Disease

Castilow¹,

Meyerholz²,

Varga

2008

The Journal of Immunology

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Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract disease in children. Children previously vaccinated with a formalin-inactivated RSV vaccine experienced enhanced morbidity and mortality upon natural RSV infection. Histological analysis revealed the presence of eosinophils in the pulmonary infiltrate of the vaccinated children. Eosinophils are characteristic of Th2 responses, and Th2 cells are known to be necessary to induce pulmonary eosinophilia in RSV-infected BALB/c mice previously immunized with a recombinant vaccinia virus (vv) expressing the RSV G protein (vvG). Using IL-13-deficient mice, we find that IL-13 is necessary for eosinophils to reach the lung parenchyma and airways of vvG-immunized mice undergoing RSV challenge infection. IL-13 acts specifically on eosinophils as the magnitude of pulmonary inflammation, RSV G protein-specific CD4 T cell responses, and virus clearance were not altered in IL-13-deficient mice. After RSV challenge, eosinophils were readily detectable in the blood and bone marrow of vvG-immunized IL-13-deficient mice, suggesting that IL-13 is required for eosinophils to transit from the blood into the lung. Pulmonary levels of CCL11 and CCL22 protein were significantly reduced in IL-13-deficient mice indicating that IL-13 mediates the recruitment of eosinophils into the lungs by inducing the production of chemokines important in Th2 cell and eosinophil chemotaxis.

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“…RSV G 183-195 -specific memory Th2 cells are recruited to the lung by the production of CCL11, CCL17, and/or CCL22 and produce IL-4, IL-5, and/or IL-13. IL-5 induces the production of eosinophils from precursors in the bone marrow [62] and is necessary for the recruitment of eosinophils into the lung [63,64]. The production of IL-13 by G 183-195 -specific memory Th2 cells and other inflammatory cells is required for the development of pulmonary eosinophilia.…”

Section: Mechanisms Of Rsv Vaccine-enhanced Diseasementioning

confidence: 99%

Overcoming T-Cell-Mediated Immunopathology to Achieve Safe Respiratory Syncytial Virus Vaccination

Castilow

Varga

2008

Future Virol.

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SummaryRespiratory syncytial virus (RSV) is the leading cause of lower respiratory tract disease in young children. Premature infants, immunocompromised individuals, and the elderly exhibit an increased risk for the development of severe disease after RSV infection. Currently, there is not a safe and effective RSV vaccine available, in part due to our incomplete understanding of how severe immunopathology was induced following RSV infection of children previously immunized with a formalin-inactivated RSV vaccine. Much of our current understanding of RSV vaccine-enhanced disease can be attributed to the establishment of multiple mouse models of RSV vaccination. Studies analyzing the RSV-specific immune response in mice have clearly demonstrated that both CD4 and CD8 memory T cells contribute to RSV-induced immunopathology. In this review we will focus our discussion on data generated from the mouse models of RSV immunization that have advanced our understanding of how virus-specific T cells mediate immunopathology and RSV vaccine-enhanced disease.

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Interleukin-13 but Not Interleukin-4 Prolongs Eosinophil Survival and Induces Eosinophil Chemotaxis.

Cited by 113 publications

References 29 publications

Hydroxycarbamide reduces eosinophil adhesion and degranulation in sickle cell anaemia patients

Hydroxycarbamide reduces eosinophil adhesion and degranulation in sickle cell anaemia patients

IL-13 Is Required for Eosinophil Entry into the Lung during Respiratory Syncytial Virus Vaccine-Enhanced Disease

Overcoming T-Cell-Mediated Immunopathology to Achieve Safe Respiratory Syncytial Virus Vaccination

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