Interleukin-13 +2044 G/A and +1923C/T polymorphisms are associated with asthma susceptibility in Asians

Abstract

A number of studies have reported that the interleukin 13 (IL-13) gene is associated with asthma susceptibility. However, the reported relationships between the +2044G/A and +1923C/T polymorphisms and asthma susceptibility are inconsistent, especially in Asian adults and children with atopic status. Meta-analysis was used to analyze combined data.The +2044G/A and +1923C/T polymorphisms were investigated using data from 18 and 11 studies, respectively. The results suggested that there was an association between asthma and the IL-13 +2044G/A polymorphisms: odds ratio (OR) 1.34, 95% confidence interval (CI) 1.03–1.75 for AA versus GG + GA and +1923C/T; OR 1.50, 95% CI 1.26–1.78 for TT versus CC; and OR 1.15, 95% CI 1.10–1.21 for TC versus CC. The subgroup meta-analysis demonstrated that IL-13 +2044G/A polymorphisms are associated with asthma: OR 1.47, 95% CI 1.06–2.04 for AA versus GG + GA and +1923C/T; OR 1.70, 95% CI 1.26–2.30 for TT versus CC; and OR 1.27, 95% CI 1.03–1.56 for TC versus CC. In particular, IL-13 +2044G/A polymorphisms are specifically associated with Asian ethnicity in both adults and children with atopic status. However, the 1923C/T polymorphisms were not significantly associated with age group or atopic status within the Asian subgroups. Further investigation using larger samples and meta-analysis is required. No publication bias was detected.This meta-analysis indicates that the IL13 +2044G/A and +1923C/T polymorphisms are risk factors for asthma, especially among Asians.

Asthma susceptible genes in children

“…In line with these findings, we presume IL-13 +2044 A/G and IL-4 -590 C/T polymorphisms maybe potential susceptible predictor for pediatric asthma. However, some studies showed that IL-13 -1112C/T and +1923C/T polymorphisms were correlated with increased risk of asthma in children, [ 68 , 69 , 71 ] which is different from our results. The reasons may be as follows: on the one hand, a significantly increased risk between IL-13 -1112C/T and asthma risk was observed by Liu et al [ 68 ] in overall populations, but not in Asians or Chinese.…”

“…[ 67 ] Our results demonstrated that IL-13 +2044G/A and IL-4 -590C/T polymorphisms were associated with asthma risk in total populations and Chinese, while IL-13 -1112C/T, +1923C/T polymorphisms were not associated with the risk of childhood asthma in any models. These results are partially consistent with the previous meta-analyses: Liu et al [ 68 ] and Mei and Qu [ 69 ] found that IL-13 +2044A/G polymorphism was significantly associated with asthma risk in Asian children; Zhang et al [ 70 ] found that a strong association between the IL-4 - 590 C/T polymorphism and the risk of childhood asthma; a meta-analysis showed that IL-4 -590 C/T polymorphism was associated with asthma risk among Chinese children. In line with these findings, we presume IL-13 +2044 A/G and IL-4 -590 C/T polymorphisms maybe potential susceptible predictor for pediatric asthma.…”

Asthma susceptible genes in children: A meta-analysis

“…In line with these ndings, we presume IL-13 + 2044 A/G and IL-4 -590 C/ T polymorphism maybe risk factors in pediatric asthma. However, some studies has shown that IL-13 -1112C/T and IL-13 + 1923C/T variant were correlated with increased risk of asthma in children 58,59,61 , which is different from our results. The reasons may be the following: a signi cantly increased risk between IL-13 -1112C/T and asthma risk was observed by Liu et al 58 in overall populations, but not in Asians.…”

“…Our results demonstrated that IL-13 + 2044G/A and IL-4 -590C/T polymorphism were associated with asthma risk in total populations and Asians, IL-13 -1112C/T and IL-13 + 1923C/T polymorphism were not associated with the risk of childhood asthma in any of the models. These results are partially consistent with the previous meta-analyses : Liu et al 58 and Mei et al 59 found that IL-13 + 2044A/G polymorphism was signi cantly associated with asthma risk in Asian children; Zhang et al 60 found that a strong association between the IL-4 -590 C/ T polymorphism and the risk of childhood asthma; a meta-analysis showed that IL-4 -590 C/ T polymorphism was associated with asthma risk among Chinese children. In line with these ndings, we presume IL-13 + 2044 A/G and IL-4 -590 C/ T polymorphism maybe risk factors in pediatric asthma.…”

Next Generation Exome Sequencing of paediatric Asthma Identifies Rare and Novel Variants in Candidate Genes

“…Numerous genetic and molecular studies have been carried out in the eld of asthma in both the children and in adults previously [50][51][52][53][54][55][56][57][58][59][60]. Among genetic studies, exome/NG sequencing studies has been documented throughout the global populations [61,62].…”