Interleukin-12 Promotes Enhanced Resistance toInfection of Lead-Exposed Mice

Kishikawa, Hiroko; Song, Renjie; Lawrence, David A.

doi:10.1006/taap.1997.8308

Cited by 69 publications

(26 citation statements)

References 43 publications

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“…[17] In fact, one study concluded that the administration of IL-12, a Th1-promoting cytokine, can reverse the immunotoxic effects of Pb resulting in increased resistance to intracellular infections in Pb-treated animals. [18] However, the basis for the selective susceptibility of different cell types to toxic effects of inorganic Pb compounds is still unknown.…”

Section: Introductionmentioning

confidence: 99%

Alpha Tocopherol Protects Against Immunosuppressive and Immunotoxic Effects of Lead

Fernández-Cabezudo

Al‐Hasan

Mustafa

et al. 2003

Free Radical Research

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Chronic exposure to lead (Pb) is associated with multiorgan toxicity. The precise mechanism(s) involved, however, remains incompletely defined. The present study was undertaken to analyze the effect of Pb on the immune system and determine the ability of alpha tocopherol (AT) to reverse Pb-induced immunotoxicity. Groups of TO Mice (6 per group) were treated ip for 2 weeks with saline alone, Pb acetate alone, Pb plus AT, or with AT alone. Spleens were then analyzed for (i) cellular composition by flow cytometry, (ii) cellular response to B and T cell mitogens and (iii) production of nitric oxide (NO). Pb treatment resulted in a significant state of splenomegaly associated mainly with an influx of CD11b+ myeloid cells. Surprisingly, however, these cells exhibited no upregulation in expression of activation markers and did not produce NO. The lymphocyte mitogenic responses were inhibited by > or = 70% in Pb-treated group. Concurrent treatment with Pb and AT resulted in almost a complete reversal of Pb-induced splenic cellular influx. Despite this, however, mitogenic responses in Pb + AT treated group were approximately 50% of those observed in normal (saline-treated) controls. We conclude that (1) chronic treatment with Pb acetate induces a state of splenomegaly and decreased proliferation in response to mitogenic stimuli and (2) co-treatment with AT largely reversed the cellular influx but this was associated with only a partial improvement of the mitogenic responses. These results highlight the role of AT as a potentially effective antioxidant in the immune system.

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Section: Introductionmentioning

confidence: 99%

Alpha Tocopherol Protects Against Immunosuppressive and Immunotoxic Effects of Lead

Fernández-Cabezudo

Al‐Hasan

Mustafa

et al. 2003

Free Radical Research

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“…Following 4 weeks of consumption of the experimental diet, mice (n = 4 per group) were infected with 1.5 × 10 5 colony-forming units (CFU) of Listeria monocytogenes through the tail vein on day 29 [20]. Mice were observed twice daily and mortality was noted.…”

Section: Methodsmentioning

confidence: 99%

Effect of fermented soybean products intake on the overall immune safety and function in mice

et al. 2017

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Various functional activities have been reported for the fermented soybean products doenjang (DJ) and cheonggukjang (CGJ), although no systemic investigations of their immune functions have been conducted to date. We examined the effects of an experimental diet of DJ, CGJ, or a mixture of unfermented raw material for 4 weeks on overall immunity and immune safety in mice. No significant alterations were observed in peripheral or splenic immune cells among groups. Enhanced splenic natural killer cell activity was observed in the DJ and CGJ groups compared with the plain diet group. T helper type-1 (Th1)-mediated immune responses were enhanced in the DJ and CGJ groups with an upregulated production ratio of IFN-γ vs. IL-4 and IgG2a vs. IgG1 in stimulated splenic T and B cells, respectively. Resistance to Listeria monocytogenes infection was observed in the DJ and CGJ groups. Overall, the results of this study suggest that DJ and CGJ intake consolidates humoral and cellular immunity to Th1 responses.

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“…Two studies demonstrated the protective role of recombinant IL-12 in a murine model of listeriosis [68,69]. Mice administered IL-12 showed reduced bacterial burden in the spleen and liver than control mice infected with the same dose of L. monocytogenes [68].…”

Section: Listeriosismentioning

confidence: 97%

“…recovered from the spleens and livers of infected mice [68]. Moreover, IL-12 administration enhanced resistance of heavy metal lead (Pb)-exposed mice to L. monocytogenes infection, as demonstrated by reduction in the numbers of viable bacteria in the spleen and liver of Pbexposed mice upon IL-12 administration [69].…”

Section: Listeriosismentioning

confidence: 99%

Therapeutic Modulation of Cytokines in Chronic Infectious Diseases

Villar¹,

Dongari-Bagtzoglou²

2006

CPD

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The recent increase in immunocompromised patient populations, including HIV-infected patients, cancer patients with chemotherapy-induced neutropenia, and transplant recipients receiving immunosuppressive therapy, has led to an increased incidence of clinically significant chronic opportunistic infections. Traditional treatment of chronic persistent infections has strongly relied on the use of antimicrobial drugs. However, unsatisfactory results with drug monotherapy and emergence of resistant strains have prompted the use of adjunctive cytokine therapies for the treatment of these infections. During the past decade, a wide spectrum of immunomodulators has been tested in human clinical trials and animal models of chronic infections caused by a variety of bacteria, fungi, viruses and parasites. This review compiles recent information on advances in the use of cytokines as a therapeutic strategy in chronic bacterial, parasitic, fungal and viral infections.

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Interleukin-12 Promotes Enhanced Resistance toInfection of Lead-Exposed Mice

Cited by 69 publications

References 43 publications

Alpha Tocopherol Protects Against Immunosuppressive and Immunotoxic Effects of Lead

Alpha Tocopherol Protects Against Immunosuppressive and Immunotoxic Effects of Lead

Effect of fermented soybean products intake on the overall immune safety and function in mice

Therapeutic Modulation of Cytokines in Chronic Infectious Diseases

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