interleukin-11 induces and maintains progenitors of different cell lineages during Xenopus tadpole tail regeneration

Tsujioka, Hiroshi; Kunieda, Takekazu; Katou, Yuki; Shirahige, Katsuhiko; Fukazawa, Taro; Kubo, Takeo

doi:10.1038/s41467-017-00594-5

Cited by 36 publications

(49 citation statements)

References 41 publications

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“…Consistent with this, mice deficient for il-6, gp130 or stat3 exhibit impaired liver regeneration (Cressman et al, 1996;Taub, 2004). IL-11, another IL-6 family member, is induced early in Xenopus tail regeneration and is required for this process (Tsujioka et al, 2017). JAK/STAT signaling is also crucial for the regeneration of diverse zebrafish cells and tissues, including cardiomyocytes, the retina and inner ear hair cells (Fang et al, 2013;Liang et al, 2012;Zhao et al, 2014).…”

Section: Parallels In Jak/stat Signaling Across Tissues and Across Spmentioning

confidence: 66%

JAK/STAT signaling in stem cells and regeneration: fromDrosophilato vertebrates

2019

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The JAK/STAT pathway is a conserved metazoan signaling system that transduces cues from extracellular cytokines into transcriptional changes in the nucleus. JAK/STAT signaling is best known for its roles in immunity. However, recent work has demonstrated that it also regulates critical homeostatic processes in germline and somatic stem cells, as well as regenerative processes in several tissues, including the gonad, intestine and appendages. Here, we provide an overview of JAK/STAT signaling in stem cells and regeneration, focusing on Drosophila and highlighting JAK/STAT pathway functions in proliferation, survival and cell competition that are conserved between Drosophila and vertebrates.

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Section: Parallels In Jak/stat Signaling Across Tissues and Across Spmentioning

confidence: 66%

JAK/STAT signaling in stem cells and regeneration: fromDrosophilato vertebrates

2019

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“…While there were 20 KEGG pathways significantly enriched in X1, only four pathways were enriched in X2 ( Figure 2F and Supplementary Table S5 ). To confirm the results of the bioinformatics analyses, we quantified the expressions of several genes related to tissue regeneration ( Kroehne et al, 2011 ; Tsujioka et al, 2017 ; Galvao et al, 2018 ; Yu et al, 2019 ). prg4a and klf11 were indeed upregulated only in the lesioned hemisphere ( Figure 2G ), while gfap and il6st were so in both hemispheres ( Figure 2H ).…”

Section: Resultsmentioning

confidence: 98%

Comparative Transcriptome Analysis of the Regenerating Zebrafish Telencephalon Unravels a Resource With Key Pathways During Two Early Stages and Activation of Wnt/β-Catenin Signaling at the Early Wound Healing Stage

Demırcı

Cucun

Poyraz

et al. 2020

Front. Cell Dev. Biol.

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Owing to its pronounced regenerative capacity in many tissues and organs, the zebrafish brain represents an ideal platform to understand the endogenous regeneration mechanisms that restore tissue integrity and function upon injury or disease. Although radial glial and neuronal cell populations have been characterized with respect to specific marker genes, comprehensive transcriptomic profiling of the regenerating telencephalon has not been conducted so far. Here, by processing the lesioned and unlesioned hemispheres of the telencephalon separately, we reveal the differentially expressed genes (DEGs) at the early wound healing and early proliferative stages of regeneration, i.e., 20 h post-lesion (hpl) and 3 days post-lesion (dpl), respectively. At 20 hpl, we detect a far higher number of DEGs in the lesioned hemisphere than in the unlesioned half and only 7% of all DEGs in both halves. However, this difference disappears at 3 dpl, where the lesioned and unlesioned hemispheres share 40% of all DEGs. By performing an extensive comparison of the gene expression profiles in these stages, we unravel that the lesioned hemispheres at 20 hpl and 3 dpl exhibit distinct transcriptional profiles. We further unveil a prominent activation of Wnt/β-catenin signaling at 20 hpl, returning to control level in the lesioned site at 3 dpl. Wnt/β-catenin signaling indeed appears to control a large number of genes associated primarily with the p53, apoptosis, forkhead box O (FoxO), mitogen-activated protein kinase (MAPK), and mammalian target of rapamycin (mTOR) signaling pathways specifically at 20 hpl. Based on these results, we propose that the lesioned and unlesioned hemispheres react to injury dynamically during telencephalon regeneration and that the activation of Wnt/β-catenin signaling at the early wound healing stage plays a key role in the regulation of cellular and molecular events.

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“…The following analysis was performed essentially as described previously [58] with modifications. In brief, the reads were mapped to the mouse genome GRCm38 [59] using HISAT2 [60, 61].…”

Section: Methodsmentioning

confidence: 99%

Comparison of gene expression profile of the spinal cord of sprouting-capable neonatal and sprouting-incapable adult mice

Tsujioka

Yamashita

2019

BMC Genomics

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Background The regenerative ability of severed axons in the central nervous system is limited in mammals. However, after central nervous system injury, neural function is partially recovered by the formation of a compensatory neural circuit. In a mouse pyramidotomy model, axonal sprouting of the intact side of the corticospinal tract is observed in the spinal cord, and the axons make new synapses with the denervated side of propriospinal neurons. Moreover, this sprouting ability is enhanced in neonatal mice compared to that in adult mice. Myelin-associated molecules in the spinal cord or intrinsic factors in corticospinal neurons have been investigated in previous studies, but the factors that determine elevated sprouting ability in neonatal mice are not fully understood. Further, in the early phase after pyramidotomy, glial responses are observed in the spinal cord. To elucidate the basal difference in the spinal cord, we compared gene expression profiles of entire C4–7 cervical cord tissues between neonatal (injured at postnatal day 7) and adult (injured at 8 weeks of age) mice by RNA-sequencing. We also tried to identify discordant gene expression changes that might inhibit axonal sprouting in adult mice at the early phase (3 days) after pyramidotomy. Results A comparison of neonatal and adult sham groups revealed remarkable basal differences in the spinal cord, such as active neural circuit formation, cell proliferation, the development of myelination, and an immature immune system in neonatal mice compared to that observed in adult mice. Some inflammation-related genes were selectively expressed in adult mice after pyramidotomy, implying the possibility that these genes might be related to the low sprouting ability in adult mice. Conclusions This study provides useful information regarding the basal difference between neonatal and adult spinal cords and the possible differential response after pyramidotomy, both of which are necessary to understand why sprouting ability is increased in neonatal mice compared to that in adult mice. Electronic supplementary material The online version of this article (10.1186/s12864-019-5974-9) contains supplementary material, which is available to authorized users.

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interleukin-11 induces and maintains progenitors of different cell lineages during Xenopus tadpole tail regeneration

Cited by 36 publications

References 41 publications

JAK/STAT signaling in stem cells and regeneration: fromDrosophilato vertebrates

JAK/STAT signaling in stem cells and regeneration: fromDrosophilato vertebrates

Comparative Transcriptome Analysis of the Regenerating Zebrafish Telencephalon Unravels a Resource With Key Pathways During Two Early Stages and Activation of Wnt/β-Catenin Signaling at the Early Wound Healing Stage

Comparison of gene expression profile of the spinal cord of sprouting-capable neonatal and sprouting-incapable adult mice

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