2003
DOI: 10.1124/pr.55.2.4
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Interleukin-10 Therapy—Review of a New Approach

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Cited by 831 publications
(678 citation statements)
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References 309 publications
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“…Our observations made in splenocytes of untreated rats show that CB-01-05 interferes with cytokines profile, reducing the production of IFN-c and increasing the expression of TNF-a, IL-2, and IL-10. The combined reduction of IFN-c and the increase of IL-10 could account for the observed anti-inflammatory activity of CB-01-05, considering the pivotal role of IFN-c in impairing intestinal healing [23], and the well-known immunoregulatory function of IL-10 [24]. CB-01-05 also shows a profile of activity different from that of UFH, resulting more effective as an inhibitor of IFN-c production, but consistently less potent in eliciting the release of TNF-a and, in particular, IL-2.…”
Section: Discussionmentioning
confidence: 99%
“…Our observations made in splenocytes of untreated rats show that CB-01-05 interferes with cytokines profile, reducing the production of IFN-c and increasing the expression of TNF-a, IL-2, and IL-10. The combined reduction of IFN-c and the increase of IL-10 could account for the observed anti-inflammatory activity of CB-01-05, considering the pivotal role of IFN-c in impairing intestinal healing [23], and the well-known immunoregulatory function of IL-10 [24]. CB-01-05 also shows a profile of activity different from that of UFH, resulting more effective as an inhibitor of IFN-c production, but consistently less potent in eliciting the release of TNF-a and, in particular, IL-2.…”
Section: Discussionmentioning
confidence: 99%
“…The anti-inflammatory effects of IL-10 are mediated by multiple mechanisms involving both the innate and adaptive arms of the immune system. In innate cells, these mechanisms include downregulation of proinflammatory cytokine production [58] and decreased expression of MHC-II and co-stimulatory molecules [59] resulting in decreased T cell activation. B10 cells negatively regulate the ability of dendritic cells to present Ag [60].…”
Section: B10 Cell Regulatory Effectsmentioning
confidence: 99%
“…B10 cells negatively regulate the ability of dendritic cells to present Ag [60]. In CD4 + T cells, IL-10 suppresses T H1 [50] and enhances T H2 polarization [41,59]. B10 cells suppress IFNγ and TNFα responses in vitro [60] and INFγ responses in vivo [36] by Ag-specific CD4 + T cells.…”
Section: B10 Cell Regulatory Effectsmentioning
confidence: 99%
“…The extraction and testing of ancient DNA was performed under recommended conditions (4). The B27 sequence-specific primers have been described previously (5). Negative control procedures were conducted for all extractions and all PCRs, and, as expected, showed no positive results.…”
Section: Molecular Evidence Of Hla-b27 In a Historical Case Of Ankylomentioning
confidence: 81%